Results 111 to 120 of about 12,817 (217)
C형 간염 바이러스 NS5A 단백질의 인산화에 관한 연구
, 1998 학위논문(석사) - 한국과학기술원 : 생물과학과, 1998.2, [ iv, 36 p. ]The genomic RNA of Hepatitis C virus (HCV) contains a single large open reading frame for virion Nonstructural polypeptides.
김지윤, Kim, Ji-Yun
core +1 more source
Conformational and binding properties of NS5A-D3 fragments.
, 2012 (a). Amino acid sequence of NS5A-D3A, D3B and D3C. (b). Far-UV CD spectra of NS5A-D3 (blue), D3A (red), D3B (brown) and D3C (green). (c). Superimposition of 1H-15N NMR HSQC spectra of NS5A-D3A(394–447) in the absence of (black) and in the presence of ...
Haina Qin (143174) +2 more
core +1 more source
PI4KA interacts with NS5A in HCV-infected cells.
, 2013 (A) Schematic of the Jc1(SF) viral genome containing a tandem Strep-tag II and a FLAG tag in domain III of NS5A. (B) Productive infection of hepatoma cells with the Jc1(SF) virus. Huh7.5.1 cells were infected with wild-type Jc1 (upper panels) and culture-
Shadi Salloum (342115) +1 more
core +1 more source
Effects of HCV Protein NS5A on Antiviral Gene Expression
, 2019 Hepatitis C virus (HCV) currently infects about 170 million people worldwide. HCV protein NS5A is a known inhibitor of the host innate immune response, specifically, the IFN-b production pathway.
Taetz, Sarah
core
GPS2 interacts and colocalizes with NS5A.
, 2013 (A) GPS2 interacts with NS5A in transfected cells. 293T cells (2×106) were transfected with the indicated plasmids (6 µg each). Cell lysates were immunoprecipitated with anti-Flag (F) antibody or control mouse IgG (Ig).
Xiu Xin (479782) +2 more
core +1 more source
Ombitasvir (ABT-267), a novel NS5A inhibitor for the treatment of hepatitis C
, 2014 INTRODUCTION: Chronic hepatitis C infection is a global disease with 160 million people infected worldwide. Until recently, therapy was characterized by long duration, suboptimal success rates and significant adverse drug reactions.
Stirnimann, Guido
core +1 more source
BMS-Biotin does not compete for LDV binding to NS5A.
, 2015 (A) Huh7-lunet cells were transfected with pTK-NS5A. 24 hr post transfection, cells were treated for 42 hr with a fixed concentration of BMS-Biotin and increasing concentrations of LDV or DCV.
Katherine M. Brendza (158359) +10 more
core +1 more source
, 2017 Background Data on persistence of NS5A resistance-associated substitutions (RASs) may have implications for resistance testing approaches and selection of initial and retreatment strategies. Methods Long-term persistence of NS5A RASs in HCV genotype (GT)
Hongmei Mo +13 more
core +1 more source
PC interacts and colocalizes with the HCV NS5A protein.
, 2013 PC interacts with NS5A derived from both genotype 1b and 2a. Either Huh7.5 cells (A) or HEK293T cells (B) were cotransfected with Myc-tagged NS5A of genotype 1b or 2a in the absence or presence of Flag-tagged PC.
Yun-Sook Lim (157976) +3 more
core +1 more source
Annals of HepatologyIntroduction and Objectives: Liver fibrosis remains a complication derived from a chronic Hepatitis C Virus (HCV) infection even when it is resolved, and no liver antifibrotic drug has been approved.
Tania G. Heredia-Torres +6 more
doaj +1 more source