Results 51 to 60 of about 15,799 (221)
Virology Journal, 2011 In an effort to find chemicals inhibiting the enzymatic activity of the hepatitis C virus (HCV) NS5B polymerase, a series of thiobarbituric acid derivatives were selected from a library provided by Korea Research Institute of Chemical Technology and ...
Park Mi Young +3 more
doaj +1 more source
Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis
Viruses, 2020 Persistent virus infection continuously produces non-self nucleic acids that activate cell-intrinsic immune responses. However, the antiviral defense evolved as a transient, acute phase response and the effects of persistently ongoing stimulation onto ...
Christian Urban +8 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou +10 more
wiley +1 more source
Scientific Reports, 2023 Current management of HCV infection is based on Direct-Acting Antiviral Drugs (DAAs). However, resistance-associated mutations, especially in the NS3 and NS5B regions are gradually decreasing the efficacy of DAAs.
Sirmast Faiz +9 more
doaj +1 more source
Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]
, 2018 Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core +1 more source
Hepatitis C Virus NS5B RNA Replicase Specifically Binds Ribosomes [PDF]
Microbiology and Immunology, 2000 AbstractHepatitis C virus (HCV) non‐structural protein 5B (NS5B) is an RNA replicase. We expressed full‐length NS5B (591 amino acid residues) in Escherichia coli as a fusion protein with maltose binding protein (MBP‐NS5B). MBP‐NS5B was recovered in the soluble fraction after centrifugation at 40,000 × g and affinity‐purified with amylose resin.
T, Tanaka +7 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 24, 27 April 2026.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
Liver International, Volume 46, Issue 4, April 2026.ABSTRACT The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone of hepatitis prevention ...
Oana Săndulescu +5 more
wiley +1 more source
Emerging Infectious Diseases, 2022 An HIV outbreak investigation during 2017–2018 in Unnao District, Uttar Pradesh, India, unearthed high prevalence of hepatitis C virus (HCV) antibodies among the study participants. We investigated these HCV infections by analyzing NS5B and core regions.
Arati Mane +8 more
doaj +1 more source