Results 61 to 70 of about 64,272 (317)

Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37 [PDF]

, 2020
Funding: This study was funded by an IBioIC PhD studentship (L.W.), a Leverhulme Trust Research Project (H.D. and M.H.T., project no. RPG-2014-418), a Leverhulme Trust–Royal Society Africa award (K.K.
Deng, Hai, Kyeremeh, Kwaku, Tong, Ming Him, Wu, Linrui   +3 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

On Nonlinear Observer Parameterizations and Its Application to Fault Detection ★ ★This work has been supported in part by the NSFC under Grants 61473004, 61174052 and 61210012.

IFAC-PapersOnLine, 2015
Abstract This paper investigates observer parameterizations and its application to observer-based fault detection for nonlinear systems. With the aid of coprime factorization techniques, the observer parameterization forms are first derived in terms of input-to-output approach and state space representation.
Li, Linin, Ding, Steven X., Yang, Ying, Zhang, Yong, Dominic, Shane   +4 more
openaire   +2 more sources

Blockade of transient receptor potential cation channel subfamily V member 1 promotes regeneration after sciatic nerve injury

Neural Regeneration Research, 2015
The transient receptor potential cation channel subfamily V member 1 (TRPV1) provides the sensation of pain (nociception). However, it remains unknown whether TRPV1 is activated after peripheral nerve injury, or whether activation of TRPV1 affects neural
Fei Ren, Hong Zhang, Chao Qi, Mei-ling Gao, Hong Wang, Xia-qing Li   +5 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Learning to Win in Evolutionary Two-person Boolean Game with Fixed Strategy Updating Rule**This work was partially supported by the National Natural Science Foundation in China (NSFC) under Grant 61473038.

IFAC-PapersOnLine, 2015
Abstract This paper introduces an algorithm to learn the strategy updating rule for a two- person Boolean game using the records of the history strategies and game results. The two-person game in this paper is introduced as a zero-sum game along with a Boolean strategy set, and the strategies are governed by fixed Boolean functions whose arguments ...
Hongbin Ma, Dong Wang
openaire   +2 more sources

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

A Family of Binary Sequences with 4-Valued Optimal Out-of-Phase Correlation and Large Linear Span [PDF]

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences, 2006
In this paper, a new family (r) of 2n binary sequences of period 2n-1 is proposed, where n≡2 mod 4 and gcd (r, 2n/2-1)=1. The presented family takes 4-valued out-of-phase auto- and cross-correlation values -1, ±2n/2-1, and 2n/2+1-1, and its correlation distribution is determined.
Lei Hu, Xiangyong Zeng, Wenfeng Jiang
openaire   +2 more sources

The key target of neuroprotection after the onset of ischemic stroke: secretory pathway Ca 2+ -ATPase 1

Neural Regeneration Research, 2015
The regulatory mechanisms of cytoplasmic Ca 2+ after myocardial infarction-induced Ca 2+ overload involve secretory pathway Ca 2+ -ATPase 1 and the Golgi apparatus and are well understood.
Li-hua Li, Xiang-rong Tian, Zhi-ping Hu
doaj   +1 more source

Active fault-tolerant control for an internet-based networked three-tank system [PDF]

, 2016
This brief is concerned with the active fault-tolerant control (FTC) problem for an Internet-based networked three-tank system (INTTS) serving as a benchmark system for evaluating networked FTC algorithms.
He, X, Qin, L, Wang, Z, Zhou, D
core   +1 more source