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Research Hotspot Prediction and Regular Evolutionary Pattern Identification Based on NSFC Grants Using NMF and Semantic Retrieval [PDF]

IEEE Access, 2019
Analyzing the research hotspots and regular evolutionary patterns of R&D projects can help researchers find potential information. This paper considers the titles of the National Natural Science Foundation of China (NSFC) grants that have been ...
Libo Feng
exaly   +4 more sources

Recycling and reuse of construction and demolition waste: From the perspective of national natural science foundation-supported research and research-driven application

Case Studies in Construction Materials, 2022
Construction and demolition waste (CDW) has been a worldwide issue in the process of urbanization. Chinese government at all levels introduces numerous policies to promote the research and applications of CDW.
Jinjun Xu, Yi Liu, Alessandra Simi, Ji Zhang   +3 more
doaj   +1 more source

The Supportive Role of International Government Funds on the Progress of Sepsis Research During the Past Decade (2010–2019): A Narrative Review

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2022
This narrative review aimed to clarify the characteristics of international government support for sepsis research, trends in published literature on sepsis, and potential contributions of government-source grants to progress in sepsis research between ...
Yuxin Leng PhD, Chengjin Gao MD, Fang Li PhD, Enzhong Li PhD, Fengzhu Zhang MSc   +4 more
doaj   +1 more source

Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B

EBioMedicine, 2020
Background: Slow neurotransmission including DARPP-32 signalling is implicated in substance use disorders (SUDs) by experimental systems but not yet in the human aetiology. PPP1R12B, encoding another protein in the DARPP-32 family, hasn't been studied in
Kefu Liu, Juan Zhao, Chunnuan Chen, Jie Xu, Richard L. Bell, Frank S. Hall, George F. Koob, Nora D. Volkow, Hong Qing, Zhicheng Lin   +9 more
doaj   +1 more source

N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1

EBioMedicine, 2020
Background: Metastasis is the leading cause of death in patients with osteosarcoma. Some of these patients fail to respond to chemotherapy and die of metastasis within a short period. Therefore, it is important to identify novel biomarkers to improve the
Chenliang Zhou, Zhichang Zhang, Xiaoshi Zhu, Guowei Qian, Yan Zhou, Yong Sun, Wenxi Yu, Jiahui Wang, Haiyang Lu, Feng Lin, Zan Shen, Shuier Zheng   +11 more
doaj   +1 more source

High-throughput multiplexed autoantibody detection to screen type 1 diabetes and multiple autoimmune diseases simultaneouslyResearch in context

EBioMedicine, 2019
Background: Islet autoantibodies (IAbs) are the most reliable biomarkers to assess risk of progression to clinical type 1 diabetes (T1D). There are four major biochemically defined IAbs currently used in clinical trials that are equally important for ...
Yong Gu, Zhiyuan Zhao, Kathleen Waugh, Dongmei Miao, Xiaofan Jia, Jeremy Cheng, Aaron Michels, Marian Rewers, Tao Yang, Liping Yu   +9 more
doaj   +1 more source

MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription

EBioMedicine, 2019
Background: Thymidylate synthase (TYMS) is a successful chemotherapeutic target for anticancer therapy. Numerous TYMS inhibitors have been developed and used for treating gastrointestinal cancer now, but they have limited clinical benefits due to the ...
Tingting Liu, Yumin Han, Chunhong Yu, Yan Ji, Changxu Wang, Xiaomin Chen, Xiang Wang, Jiayan Shen, Yongfeng Zhang, Jing-Yu Lang   +9 more
doaj   +1 more source

Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder

EBioMedicine, 2019
Background: Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs), and fimbrial tip adhesins, play important roles in UPEC colonization.
Xiao Li, Geng Pei, Lisong Zhang, Yang Cao, Jingyu Wang, Lu Yu, Wei Dianjun, Shan Gao, Zhi-Song Zhang, Zhi Yao, Quan Wang   +10 more
doaj   +1 more source

Phosphorylated Rasal2 facilitates breast cancer progression

EBioMedicine, 2019
Background: Rasal2 has diametric effects on progression of oestrogen receptor-positive (ER+) and -negative (ER–) breast cancers. The relevant causes are unknown.
Xuan Wang, Christopher Qian, Yinlong Yang, Meng-Yue Liu, Ya Ke, Zhong-Ming Qian   +5 more
doaj   +1 more source

Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit

Neural Regeneration Research, 2015
The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair peripheral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral ...
Pei-xun Zhang, A Li-ya, Yu-hui Kou, Xiao-feng Yin, Feng Xue, Na Han, Tian-bing Wang, Bao-guo Jiang   +7 more
doaj   +1 more source