Results 41 to 50 of about 75,562 (190)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

Composition of nanoclay supported silver nanoparticles in furtherance of mitigating cytotoxicity and genotoxicity.

open access: yesPLoS ONE, 2021
Silver nanoparticle (Ag-NP) is well known for its high antibacterial efficacy. However, its toxicity toward mammalian cells is still a concern in clinical applications.
Chih-Hao Chang   +5 more
doaj   +1 more source

Coexistence Analysis between Radar and Cellular System in LoS Channel

open access: yes, 2016
Sharing spectrum with incumbents such as radar systems is an attractive solution for cellular operators in order to meet the ever growing bandwidth requirements and ease the spectrum crunch problem.
Abdelhadi, Ahmed   +2 more
core   +1 more source

A Rice method proof of the Null-Space Property over the Grassmannian [PDF]

open access: yes, 2017
18 Pages, some Figures.International audienceThe Null-Space Property (NSP) is a necessary and sufficient condition for the recovery of the largest coefficients of solutions to an under-determined system of linear equations.
Azaïs, Jean-Marc   +2 more
core   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

open access: yesAdvanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui   +3 more
wiley   +1 more source

Mining Interesting Negative Sequential Patterns Based on Influence

open access: yesIEEE Access, 2023
Negative sequential pattern (NSP) mining can capture frequently occurring and non-occurring behavior information and can play an irreplaceable role in many applications.
Fengling Cui   +2 more
doaj   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

open access: yesAdvanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu   +9 more
wiley   +1 more source

Computational Complexity versus Statistical Performance on Sparse Recovery Problems [PDF]

open access: yes, 2018
We show that several classical quantities controlling compressed sensing performance directly match classical parameters controlling algorithmic complexity.
Boumal, Nicolas   +2 more
core   +5 more sources

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

open access: yesAdvanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei   +7 more
wiley   +1 more source

Development and Evaluation of Tannic Acid-Coated Nanosuspension for Enhancing Oral Bioavailability of Curcumin

open access: yesPharmaceutics, 2021
Curcumin (CUR) has been used in the treatment of various diseases such as cough, fever, skin disease, and infection because of various biological benefits such as anti-inflammatory, antiviral, antibacterial, and antitumor activity.
Hyeonmin Lee   +6 more
doaj   +1 more source

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