Results 1 to 10 of about 38,049 (143)

Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 [PDF]

Molecular Therapy: Nucleic Acids
RdRp is a critical component of an RNA virus life cycle. Among coronaviruses, NSP12, along with one copy of NSP7 and two copies of NSP8, forms the RdRp holoenzyme and exhibits polymerase activity.
Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal, Saras H. Tiwari, Arkadyuti Ghorai, Manoj Kumar, Saroj Kumar, Soumya De, Aparoy Polamarasetty, Deepak Sehgal, Madhumohan R. Katika, Suresh Gadde, Marceline Côté, Sarala R. Kayampeta, Mohan Babu Appaiahgari, Krishna K. Inampudi   +17 more
doaj   +4 more sources

Cellular eEF1G Inhibits Porcine Deltacoronavirus Replication by Binding Nsp12 and Disrupting Its Interaction with Viral Genomic RNA [PDF]

Viruses
Porcine deltacoronavirus (PDCoV) is an emerging pathogen that causes severe, often fatal, diarrhea in suckling piglets and has zoonotic potential. Its nonstructural protein 12 (Nsp12), functioning as the RNA-dependent RNA polymerase (RdRp), is a central ...
Weijia Yin, Xinna Ge, Lei Zhou, Xin Guo, Jun Han, Yongning Zhang, Hanchun Yang   +6 more
doaj   +4 more sources

SARS-CoV-2 Remdesivir Exposure Leads to Different Evolutionary Pathways That Converge in Moderate Levels of Drug Resistance [PDF]

Viruses
Various SARS-CoV-2 remdesivir resistance-associated substitutions (RAS) have been reported, but a comprehensive comparison of their resistance levels is lacking.
Carlota Fernandez-Antunez, Line A. Ryberg, Kuan Wang, Long V. Pham, Lotte S. Mikkelsen, Ulrik Fahnøe, Katrine T. Hartmann, Henrik E. Jensen, Kenn Holmbeck, Jens Bukh, Santseharay Ramirez   +10 more
doaj   +2 more sources

Galectin 3-binding protein suppresses PRRSV replication via Cullin3-mediated ubiquitination degradation of non-structural protein 12 [PDF]

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a major threat to the global swine industry, yet effective antiviral strategies remain limited.
Xinrong Wang, Wenli Zhang, Juan Zhang, Rui Li, Longxiang Zhang, Nan Yan, Junhai Zhu, Lizhi Fu, Yue Wang   +8 more
doaj   +2 more sources

Preclinical Screening Platform Identifies Azatadine-Dimaleate as a Potent Repurposed Therapeutic Against SARS-CoV-2 Infection. [PDF]

J Med Virol
ABSTRACT The emergence of SARS‐CoV‐2 posed a major global public health threat, necessitating urgent development of therapeutics. Despite vaccine availability, continuous emergence of viral variants with enhanced transmissibility and immune escape capabilities, and consequential impacts on health services, requires effective antiviral therapeutics ...
Ali A, Courtney D, Broadbent L, Sharma P, Bamford CGG, Manzoor S, Touzelet O, McCaughey C, Kirby A, Bentley E, Kipar A, Mills KI, Stewart JP, Power UF.   +13 more
europepmc   +2 more sources

Five-Year (2017-2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next-Generation Sequencing. [PDF]

J Med Virol
ABSTRACT HCoV‐OC43 genomes and their evolution are scarcely studied worldwide and in France, with only 361 genomes available as of October 2023. Here, an in‐house PCR amplification system was implemented to obtain retrospectively by next‐generation sequencing, then analyze HCoV‐OC43 genomes for infections diagnosed with this virus in southern France ...
Houmadi H, Boschi C, Lefebvre M, Le Targa L, Py J, Lagier JC, Lesage L, Fantini J, Morand A, La Scola B, Colson P.   +10 more
europepmc   +2 more sources

Antiviral Activity of Remdesivir and Obeldesivir Against SARS-CoV-2 Omicron Subvariants That Were Circulating from September 2023 Through June 2025 [PDF]

Viruses
With the ongoing emergence of SARS-CoV-2 variants, continued surveillance of antiviral susceptibility remains critical for detecting resistance that could compromise treatment efficacy.
Lauren Rodriguez, Jiani Li, Dong Han, Nadine Peinovich, Clarissa Martinez, Pui Yan Ho, J. Lizbeth Reyes Zamora, Ross Martin, John P. Bilello, Jason K. Perry, Charlotte Hedskog   +10 more
doaj   +2 more sources

Fisetin as an Antiviral Agent Targeting the RNA-Dependent RNA Polymerase of SARS-CoV-2: Computational Prediction and In Vitro Experimental Validation [PDF]

Microorganisms
SARS-CoV-2 continues to evolve into immune-evasive variants, and although vaccination remains the cornerstone of prevention, the search for antiviral molecules targeting conserved viral enzymes remains essential.
Ximena Hernández-Rodríguez, Flor Itzel Lira-Hernández, José Manuel Reyes-Ruíz, Juan Fidel Osuna-Ramos, Carlos Noe Farfán-Morales, Daniela Nahomi Calderón-Sandate, Julio Enrique Castañeda-Delgado, Moisés León-Juárez, Rosa María del Ángel, Bruno Rivas-Santiago, Saúl Noriega, David Mauricio Cañedo-Figueroa, Sarita Montaño, Alan Orlando Santos-Mena, Ana Cristina García-Herrera, Luis Adrián De Jesús-González   +15 more
doaj   +2 more sources

Remdesivir and Obeldesivir Retain Potent Antiviral Activity Against SARS-CoV-2 Omicron Variants [PDF]

Viruses
As new SARS-CoV-2 variants continue to emerge, it is important to evaluate the potency of antiviral drugs to support their continued use. Remdesivir (RDV; VEKLURY®) an approved antiviral treatment for COVID-19, and obeldesivir (ODV) are inhibitors of the
Lauren Rodriguez, J. Lizbeth Reyes Zamora, Dong Han, Jasmine Moshiri, Nadine Peinovich, Clarissa Martinez, Pui Yan Ho, Jiani Li, Thomas Aeschbacher, Ross Martin, Andrew Pekosz, John P. Bilello, Jason K. Perry, Charlotte Hedskog   +13 more
doaj   +2 more sources

The impact of remdesivir on SARS-CoV-2 evolution in vivo [PDF]

JCI Insight
The impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo has remained unclear. In this single-center, retrospective cohort study, we assessed SARS-CoV-2 diversification and diversity over time in a cohort of hospitalized patients who did or
Ted Ling-Hu, Lacy M. Simons, Estefany Rios-Guzman, Alexandre Machado Carvalho, Maria Francesca R. Agnes, Arghavan Alisoltanidehkordi, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist   +8 more
doaj   +2 more sources