Results 91 to 100 of about 38,142 (142)

Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9

PLoS ONE, 2023
Nsp9 is a conserved accessory component of the coronaviral replication and transcription complex. It is the predominant substrate of nsp12’s nucleotidylation activity while also serving to recruit proteins required for viral 5’-capping.
Yue Pan, Indu R. Chandrashekaran, Luke Tennant, Jamie Rossjohn, Dene R. Littler   +4 more
doaj  

No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials

Viruses
Remdesivir (RDV) is a broad-spectrum nucleotide analog prodrug approved for the treatment of COVID-19 in hospitalized and non-hospitalized patients with clinical benefit demonstrated in multiple Phase 3 trials.
Charlotte Hedskog, Christoph D. Spinner, Ulrike Protzer, Dieter Hoffmann, Chunkyu Ko, Robert L. Gottlieb, Medhat Askar, Meta Roestenberg, Jutte J. C. de Vries, Ellen C. Carbo, Ross Martin, Jiani Li, Dong Han, Lauren Rodriguez, Aiyappa Parvangada, Jason K. Perry, Ricard Ferrer, Andrés Antón, Cristina Andrés, Vanessa Casares, Huldrych F. Günthard, Michael Huber, Grace A. McComsey, Navid Sadri, Judith A. Aberg, Harm van Bakel, Danielle P. Porter   +26 more
doaj   +1 more source

Additional file 1 of Development of novel monoclonal antibodies against nsp12 of SARS-CoV-2

Additional file1. Figure S1: Screening of anti-nsp12 mouse monoclonal antibodies using the culture supernatant of hybridomas. Figure S2: Selection of anti-nsp12 mouse monoclonal antibodies to discriminate between nsp12 of SARS-CoV and SARS-CoV-2.
Machitani, Mitsuhiro, Takei, Junko, Kaneko, Mika K., Ueki, Saori, Ohashi, Hirofumi, Watashi, Koichi, Kato, Yukinari, Masutomi, Kenkichi   +7 more
openaire   +1 more source

Development of RNA Aptamers That Inhibit the RNA-Dependent RNA Polymerase Activity of SARS-CoV-2 Strains In Vitro. [PDF]

Int J Mol Sci
Song C, Lee SW.
europepmc   +1 more source

Fusion Strategy of DNA-Encoded Libraries Drives Discovery of Allosteric Inhibitors of SARS-CoV‑2 RdRp. [PDF]

JACS Au
Li L, Wang X, Ding P, Shen X, Hu H, Wang X, Jin R, Wu X, Zhang Y, Lu W, Yue J, Xu HE, Yin W, Xu Y, Lu X.   +14 more
europepmc   +1 more source

Is the P323L mutation in nsp12 of SARS-CoV-2 a host species marker?

The SARS-CoV-2 replication and transcription complex (RTC) provides RNA-dependent RNA polymerase (RdRp) activity. In its minimal composition, it consists of ‘non-structural proteins’, including nsp12 in complex with its protein cofactors: one copy of nsp7 and two of nsp8.
Falcou, Camille, Eydoux, Cécilia, Lo-Belo, Léa, Snijder, Eric, Canard, Bruno   +4 more
openaire   +1 more source

Transient complexes of the Nsp7, Nsp8 and Nsp12 in SARS-CoV-2 replication transcription complex [PDF]

Acta Crystallographica Section A Foundations and Advances, 2021
openaire   +1 more source

Nucleocapsid protein captures DDX5 and RNMT facilitating viral RNA synthesis and viral protein translation for coronavirus replication. [PDF]

mBio
Liu Y, Kong N, Yang X, Qin W, Wang Y, Wang C, Sun H, Wang J, Gao A, Zheng D, Tong W, Yu H, Zheng H, Tong G, Shan T.   +14 more
europepmc   +1 more source

Polypeptide encoded by the -1 PRF signal of SARS-CoV-2 controls multiple enzymatic activities of the viral NiRAN domain. [PDF]

NAR Mol Med
Hsu HT, Cho CP, Lin CL, Chang KY.
europepmc   +1 more source

Reprogramming of lipid metabolism by ORF3a-induced microlipophagy enhances biogenesis of SARS-CoV-2 replication organelle. [PDF]

PLoS Pathog
Li Z, Hui X, Zheng M, He Z, Huai W, Ding B, Jin M, Qin Y, Chen M.   +8 more
europepmc   +1 more source