Results 101 to 110 of about 38,142 (142)

Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach. [PDF]

ACS Infect Dis
Malune P, Iaconis D, Manelfi C, Giunta S, Emmolo R, Lunghini F, Paulis A, Talarico C, Corona A, Beccari AR, Tramontano E, Esposito F.   +11 more
europepmc   +1 more source

Porcine Mx1 protein inhibits porcine deltacoronavirus replication in vitro by disturbing the N-Nsp12 interaction

Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen with significant economic impact and potential zoonotic risk. The interplay between PDCoV and host innate immunity, particularly involving interferon-stimulated genes (ISGs), remains incompletely understood.
openaire   +1 more source

Development of GFP-expressing infectious clones for PRRSV using TAR cloning for antiviral drug screening. [PDF]

Npj Viruses
Zhang M, Qian B, Kunec D, Veit M.
europepmc   +1 more source

A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent. [PDF]

Nucleic Acids Res
Klein M, Das A, Bera SC, Anderson TK, Kocincova D, Lee HW, Wang B, Papini FS, Marecki JC, Arnold JJ, Cameron CE, Raney KD, Artsimovitch I, Götte M, Kirchdoerfer RN, Depken M, Dulin D.   +16 more
europepmc   +1 more source

Lung-targeted delivery of nsp12 siRNAs restores host type I interferon responses

Chemical Engineering Journal
Xinhui Lan, Hexiang Li, Jiahua Guo, Chao Feng, Xinrui Zhou, Jingyuan Wang, Daxu Li, Meiju Ji, Peng Hou, Qi Yang   +9 more
openaire   +1 more source

Incorporation of arabinose-CTP and arabinose-UTP inhibits viral polymerases by inducing long pauses. [PDF]

J Biol Chem
Xiao Z, Das A, Jain A, Anderson TK, Cameron CE, Arnold JJ, Dulin D, Kirchdoerfer RN.   +7 more
europepmc   +1 more source

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription. [PDF]

J Virol
Perry JK, Itskanov S, Bilello JP, Lansdon EB.   +3 more
europepmc   +1 more source

RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction. [PDF]

ACS Nano
Jiang X, Xu J, Liao Z, Wang N, Zuo T, Ma C, Jiang H, Ke Y, Cheng H, Wang H, Zhao J, Fan J, Liu J, Chu X.   +13 more
europepmc   +1 more source

Key amino acids in RNA polymerase and helicase proteins regulate RNA synthesis efficiency in porcine reproductive and respiratory syndrome virus. [PDF]

J Biol Chem
Li H, Zhang R, Xie H, Zhou Y, Wang X.
europepmc   +1 more source

SARS-CoV-2 mutant spectrum complexity is an epidemiologically evolvable trait. [PDF]

Proc Natl Acad Sci U S A
Martínez-González B, Soria ME, de Ávila AI, Somovilla P, Aguilar-Sabido C, Mínguez P, Ferrer-Orta C, Salar-Vidal L, Lorenzo-Redondo R, Delgado S, Morán F, Verdaguer N, Gadea I, Domingo E, Perales C.   +14 more
europepmc   +1 more source