Results 31 to 40 of about 38,049 (143)
Mechanism of nucleic acid unwinding by SARS-CoV helicase. [PDF]
PLoS ONE, 2012 The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5' → 3' polarity, using the energy of nucleotide hydrolysis.
Adeyemi O Adedeji +7 more
doaj +1 more source
iScience, 2021 Summary: The use of remdesivir to treat COVID-19 will likely continue before clinical trials are completed. Due to the lengthening pandemic and evolving nature of the virus, predicting potential residues prone to mutation is crucial for the management of
Aditya K. Padhi +3 more
doaj +1 more source
Research, 2022 Despite extensive efforts, COVID-19 pandemic caused by the SARS-CoV-2 virus is still at large. Vaccination is an effective approach to curb virus spread, but several variants (e.g., delta, delta plus, omicron, and IHU) appear to weaken or possibly escape
Yasen Maimaitiyiming +9 more
doaj +1 more source
Emerging Microbes and Infections, 2023 Zoonotic transmission of coronaviruses (CoVs) poses a serious public health threat. Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to ...
Yu-Lin Yao +16 more
doaj +1 more source
Deciphering the NSP12/7/8 complex: Key insights into coronavirus replication and potential therapeutic targets. [PDF]
Mol Ther Nucleic AcidsLuwen G, Liyan Z, Rahman A, Baloch Z.
europepmc +2 more sources
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Signal Transduction and Targeted Therapy, 2022 The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have ...
Saisai Guo +18 more
doaj +1 more source
Microorganisms, 2021 A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir ...
Alfredo Mari +24 more
doaj +1 more source
Biochemical and Biophysical Research Communications, 2021 The pandemic of SARS-CoV-2 has necessitated expedited research efforts towards finding potential antiviral targets and drug development measures. While new drug discovery is time consuming, drug repurposing has been a promising area for elaborate virtual screening and identification of existing FDA approved drugs that could possibly be used for ...
Feroza Begum +2 more
openaire +2 more sources
Digging for the Discovery of SARS-CoV-2 nsp12 Inhibitors: A Pharmacophore-Based and Molecular Dynamics Simulation Study [PDF]
Future Virology, 2021 Abstract Background: The severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is a grave global threat causing Coronavirus Disease 2019 (COVID-19). The therapeutics are urgently needed to cure patients severely infected with COVID-19. The aim of the study was to investigate for potential candidates of nsp12 inhibitors by searching for ...
Fatemeh Sana Askari +5 more
openaire +2 more sources
Pathogens, 2023 Heat shock protein 27 (HSP27) is a multifunctional protein and belongs to the small HSP family. It has been shown that HSP27 is involved in viral replication as a cellular chaperone, but the function of HSP27 during porcine reproductive and respiratory ...
Chunhui Song +4 more
doaj +1 more source