Results 41 to 50 of about 38,049 (143)
Microbiology Spectrum, 2022 Remdesivir (RDV) was the first antiviral drug approved by the FDA to treat severe coronavirus disease-2019 (COVID-19) patients. RDV inhibits SARS-CoV-2 replication by stalling the non structural protein 12 (nsp12) subunit of the RNA-dependent RNA ...
Marta Santos Bravo +24 more
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Scientific Reports, 2021 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with fatal pulmonary fibrosis.
Seung Hyun Ahn +4 more
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Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2 [PDF]
Cell Reports, 2020 The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2). The viral polymerase is a promising antiviral target.
Peng, Qi +11 more
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PLoS ONE, 2021 The 2019 emergence of, SARS-CoV-2 has tragically taken an immense toll on human life and far reaching impacts on society. There is a need to identify effective antivirals with diverse mechanisms of action in order to accelerate preclinical development ...
Matthew R Freidel, Roger S Armen
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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase [PDF]
Biochemical Journal, 2021 The coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest public health and economic crisis in recent history impacting virtually all sectors of society. There is a need for effective therapeutics to battle the ongoing pandemic.
Agustina P. Bertolin +11 more
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PLoS ONE, 2021 To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed.
Clément Madru +6 more
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Preparation of SARS-CoV-2 Polymerase Nsp12 and Optimization of Expression Conditions
Sustainability in Environment, 2023 he core component of transcription and replication of SARS-CoV-2 is Nsp12, a non-structural protein that function as an RNA-dependent RNA polymerase. Nsp12 is a key drug target for the development of anti-coronavirus drugs. The purpose of this study was to explore and optimize the expression conditions of Nsp12 of SARS-CoV-2 with the aim of ...
openaire +1 more source
Repurposed drug molecules targeting NSP12 protein of SARS-CoV-2: An in-silico study
AIMS Molecular Science, 2023 <abstract> <p>The emergence of SARS-CoV-2 created a havoc worldwide, causing high morbidity, serious complications and mortality. The ORF1ab of SARS-CoV-2 has 16 non-structural proteins which are required for genome replication and transcription. All of these are druggable targets, of which NSP12 (RNA-dependent RNA polymerase), was selected
Bhawna Sharma +14 more
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Frontiers in Molecular BiosciencesBackground: The RNA-dependent RNA polymerase (RdRp) complex, essential in viral transcription and replication, is a key target for antiviral therapeutics.
José Xavier Lima Neto +11 more
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Host-dependent editing of SARS-CoV-2 in COVID-19 patients
Emerging Microbes and Infections, 2021 A common trait among RNA viruses is their high capability to acquire genetic variability due to viral and host mechanisms. Next-generation sequencing (NGS) analysis enables the deep study of the viral quasispecies in samples from infected individuals. In
Josep Gregori +20 more
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