Results 51 to 60 of about 38,049 (143)
Antiviral Research, 2020 The rapid global emergence of SARS-CoV-2 has been the cause of significant health concern, highlighting the immediate need for antivirals. Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative treatment of several viral diseases, due to high ...
Shannon, Ashleigh +9 more
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Vitamin
IUBMB Life, 2020 AbstractSARS‐CoV‐2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive‐sense single‐stranded RNA genome. The genome encodes for the nsp12 protein, which houses the RNA‐dependent‐RNA polymerase (RdRP) activity responsible for the ...
Narayanan, Naveen, Nair, Deepak T.
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SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption
Journal of Virology, 2023 ABSTRACT SARS-CoV-2 emerged in the human population in late 2019, and human-to-human transmission has dominated the evolutionary landscape and driven the selection of different lineages. The first major change that resulted in increased transmission was the D614G substitution in the spike protein.
Muhannad Alruwaili +8 more
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In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.
PLoS Pathogens, 2021 Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports identifying SARS-CoV-2 RDV resistance in patients, animal models or in vitro ...
Agnieszka M Szemiel +19 more
doaj +1 more source
Virus Research, 2023 Porcine reproductive and respiratory syndrome virus (PRRSV) has seriously affected the viability of swine industries worldwide, and effective measures to control PRRSV are urgently required. Understanding the mechanisms of action of antiviral proteins is
Yujiao Zhang +11 more
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Remdesivir in COVID‐19: A Focus on Pediatric Cardiac Patients
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.The coronavirus disease 2019 (COVID‐19) pandemic has presented a significant global health challenge that necessitated the immediate search for various therapeutic modalities. Remdesivir, an antiviral drug inhibiting RNA‐dependent RNA polymerase (RdRp), was among the most heavily used drugs against COVID‐19.
Dima Bsat +3 more
wiley +1 more source
Caspofungin and LTX-315 inhibit SARS-CoV-2 replication by targeting the nsp12 polymerase [PDF]
, 2020 Abstract The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously designated as 2019-nCoV) outbreak has caused global concern1. Currently, there are no clinically approved specific drugs or vaccines available for this virus.
Min Wang +17 more
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Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.We show that antisense oligonucleotides can be used to restructure secondary structural elements around the circular DNA template binding sites of the genomic RNA for subsequent rolling circle amplification. This strategy was employed to identify otherwise COVID “false negative” saliva samples by accurately detecting the presence of SARS‐CoV‐2 genomic ...
Amal Mathai +4 more
wiley +2 more sources
Viruses, 2015 Human coronavirus OC43 (HCoV-OC43) is one of five currently circulating human coronaviruses responsible for respiratory infections. Like all coronaviruses, it is characterized by its genome’s high plasticity.
Nathalie Kin +5 more
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APMIS, Volume 133, Issue 12, December 2025.ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson +5 more
wiley +1 more source