Results 61 to 70 of about 38,049 (143)

Role of remdesivir for the treatment of COVID‐19 in patients with hematologic malignancy—A narrative review and expert opinion

European Journal of Clinical Investigation, Volume 55, Issue 12, December 2025.
Created in BioRender. Ghezzi, S. (2025) https://BioRender.com/q1lticg. Abstract Background COVID‐19 remains a potentially severe condition for immunocompromised individuals, such as patients with hematologic malignancy. These patients are at increased risk of progressing to severe–critical or prolonged COVID‐19.
Malgorzata Mikulska, Matteo Bassetti, Alessandro Busca, Valeria Cento, Maddalena Giannella, Michele Bartoletti   +5 more
wiley   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, Volume 12, Issue 41, November 6, 2025.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

A genus-specific nsp12 region impacts polymerase assembly in Alphacoronavirus and Gammacoronavirus

Journal of Biological Chemistry
Coronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within the Coronavirinae subfamily and high infection frequency in animal species worldwide creates a looming threat that calls for research across all
Peter J. Hoferle, Thomas K. Anderson, Robert N. Kirchdoerfer   +2 more
openaire   +2 more sources

Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2

, 2020
A novel coronavirus (SARS-CoV-2) that is initially found to trigger human severe respiratory illness in Wuhan City of China in 2019, has killed 2,718 people in China by February 26, 2020, and which has been recognized as a public health emergency of international concern as well.
Ruan, Zijing, Liu, Chao, Guo, Yuting, He, Zhenqing, Huang, Xinhe, Jia, Xu, Yang, Tai   +6 more
openaire   +2 more sources

In silico analysis of non-structural protein 12 sequences from SARS-COV-2 found in Manaus, Amazonas, Brazil, reveals mutations linked to higher transmissibility

Anais da Academia Brasileira de Ciências
The disease coronavirus COVID-19 has been the cause of millions of deaths worldwide. Among the proteins of SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part of the RNA-dependent RNA polymerase complex.
FERNANDO B. ZANCHI, GABRIEL EDUARDO M. FERREIRA, LUIS ANDRÉ M. MARIÚBA, JULIANE C. GLÓRIA, VALDINETE A. DO NASCIMENTO, VICTOR C. DE SOUZA, ANDRÉ DE LIMA G. CORADO, FERNANDA O. DO NASCIMENTO, ÁGATHA KÉLLY A. DA COSTA, DÉBORA CAMILA G. DUARTE, GEORGE ALLAN V. DA SILVA, MATILDE DEL CARMEN C. MEJÍA, KARINA P. PESSOA, LUCIANA MARA F. GONÇALVES, MARIA JÚLIA P. BRANDÃO, MICHELE S. DE JESUS, MARINEIDE S. DA SILVA, CRISTIANO F. DA COSTA, FELIPE G. NAVECA   +18 more
doaj   +1 more source

SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12. [PDF]

J Cell Biol
β-coronavirus rearranges the host cellular membranes to form double-membrane vesicles (DMVs) via NSP3/4, which anchor replication–transcription complexes (RTCs), thereby constituting the replication organelles (ROs). However, the impact of specific domains within NSP3/4 on DMV formation and RO assembly remains largely unknown.
Yang J, Tian B, Wang P, Chen R, Xiao K, Long X, Zheng X, Zhu Y, Sun F, Shi Y, Jiu Y, Ji W, Xue Y, Xu T, Li Z.   +14 more
europepmc   +3 more sources

Implementation of a Multiplex PCR Amplification System Combined With Next‐Generation Genome Sequencing to Decipher the Circulation of Human Coronavirus 229E Lineages in Southern France

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Coronaviruses rapidly evolve and are prone to new virus emergence. Human coronavirus (HCoV)−229E is one of the seven coronaviruses (aside HCoV‐OC43, HCoV‐HKU1, HCoV‐NL63, SARS‐CoV, MERS‐CoV, SARS‐CoV‐2) causing respiratory infections in humans. Genomic data are very scarce for this virus.
Houmadi Hikmat, Justine Py, Céline Boschi, Emilie Burel, Lorlane Le Targa, Matthieu Million, Lucile Lesage, Aurélie Morand, Bernard La Scola, Philippe Colson   +9 more
wiley   +1 more source

Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication

Viruses, 2022
The COVID-19 pandemic continues to threaten healthcare systems worldwide due to the limited access to vaccines, suboptimal treatment options, and the continuous emergence of new and more transmissible SARS-CoV-2 variants.
Ulrik Fahnøe, Long V. Pham, Carlota Fernandez-Antunez, Rui Costa, Lizandro René Rivera-Rangel, Andrea Galli, Shan Feng, Lotte S. Mikkelsen, Judith M. Gottwein, Troels K. H. Scheel, Santseharay Ramirez, Jens Bukh   +11 more
doaj   +1 more source

Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study

Indonesian Journal of Biotechnology
Human coronaviruses (HCoVs) are responsible for mild common cold to severe pneumonia‐like symptoms in infected individuals. The first HCoV was HCoV‐229E, discovered in 1962 in the US, which causes moderate symptoms.
Bhawna Sharma, Bennet Angel, Annette Angel, Vinod Joshi, Shareef Mohammed Buvvaji, Neha Singh, Khushbu Kumari, Aarya Chitransh, Poorna Khaneja, Devendra Kumar   +9 more
doaj   +1 more source

SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes

Microbiology Spectrum, 2022
Mutant spectra of RNA viruses are important to understand viral pathogenesis and response to selective pressures. There is a need to characterize the complexity of mutant spectra in coronaviruses sampled from infected patients.
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Isabel Gallego, Ana Isabel de Ávila, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales   +25 more
doaj   +1 more source