Results 81 to 90 of about 38,142 (142)

A genus-specific nsp12 region impacts polymerase assembly in Alpha- and Gammacoronaviruses

AbstractCoronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within theCoronavirinaesubfamily and high infection frequency in animal species worldwide creates a looming threat that calls for research ...
Peter J. Hoferle, Thomas K. Anderson, Robert N. Kirchdoerfer   +2 more
openaire   +2 more sources

Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
SARS‐CoV‐2 nsp13 is a promising target to develop effective antivirals. Pursuing the studies, new indolyl derivatives to deepen SARs are designed. The newly synthesized N‐aryl indoles are active vs both nsp13‐associated activities. They exert antiviral activity vs SARS‐CoV‐2 infected cells with no cytotoxicity.
Valentina Noemi Madia, Roberta Emmolo, Elisa Patacchini, Donatella Amatore, Stefania Maloccu, Davide Ialongo, Aurora Albano, Giuseppe Ruggieri, Emanuele Cara, Laura Zarbo, Antonella Messore, Riccardo De Santis, Alessandra Amoroso, Florigio Lista, Francesca Esposito, Enzo Tramontano, Angela Corona, Roberto Di Santo, Roberta Costi   +18 more
wiley   +1 more source

Small Molecules as Regulators of Liquid–Liquid Phase Separation: Mechanisms and Strategies for New Drug Discovery

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Diverse small‐molecule condensate‐modifying therapeutics (c‐mods) engage condensates through π–π stacking, cation–π, hydrogen bonding, and electrostatic contacts to selectively dissolve pathological assemblies or stabilize functional condensates. Highlighted aromatic cores and polar substituents mediate specific interactions, while counter‐anion ...
Abdurrahman Usman, Anas Yusuf, Murtala Bindawa Isah, Mei Dang, Xiaoying Zhang   +4 more
wiley   +1 more source

Chinese herbal medicine‐derived extracellular vesicle‐like particles: Therapeutic potential and future research approaches

Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.
This article evaluates the therapeutic potential of extracellular vesicle‐like particles derived from Chinese herbal medicine (CHM‐EVLP) for a range of diseases. It underscores the significance of traditional Chinese medicine in the development of innovative formulations.
Ying‐qi Cao, Zheng‐ting Wu, Qi You, Yuan‐yuan Xia, Qing Zhao, Carine de Marcos Lousa, Ke‐wei Zhao   +6 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins

mBio, 2017
Coronavirus (CoV) replication and transcription are carried out in close proximity to restructured endoplasmic reticulum (ER) membranes in replication/transcription complexes (RTC).
Jeremiah Athmer, Anthony R. Fehr, Matthew Grunewald, Everett Clinton Smith, Mark R. Denison, Stanley Perlman   +5 more
doaj   +1 more source

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

mBio, 2018
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity.
Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison   +16 more
doaj   +1 more source

Characteristics of SARS-CoV-2 Omicron BA.5 variants in Shanghai after ending the zero-COVID policy in December 2022: a clinical and genomic analysis

Frontiers in Microbiology
IntroductionAn unprecedented surge of Omicron infections appeared nationwide in China in December 2022 after the adjustment of the COVID-19 response policy.
Pengcheng Liu, Jiehao Cai, He Tian, Jingjing Li, Lijuan Lu, Menghua Xu, Xunhua Zhu, Xiaomin Fu, Xiangshi Wang, Huaqing Zhong, Ran Jia, Yanling Ge, Yanfeng Zhu, Mei Zeng, Jin Xu, Jin Xu   +15 more
doaj   +1 more source

Direct Detection of Viral Infections from Swab Samples by Probe‐Gated Silica Nanoparticle‐Based Lateral Flow Assay

ChemistryOpen
Point‐of‐care diagnosis is crucial to control the spreading of viral infections. Here, universal‐modifiable probe‐gated silica nanoparticles (SNPs) based lateral flow assay (LFA) is developed in the interest of the rapid and early detection of viral ...
Dilara Buse Durdabak, Soner Dogan, Serap Demir Tekol, Caner Celik, Veli Cengiz Ozalp, Bilge Guvenc Tuna   +5 more
doaj   +1 more source

Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections

Nature Communications
We investigated the impact of antiviral treatment on the emergence of SARS-CoV-2 resistance during persistent infections in immunocompromised patients (n = 15).
Mohammed Nooruzzaman, Katherine E. E. Johnson, Ruchi Rani, Eli J. Finkelsztein, Leonardo C. Caserta, Rosy P. Kodiyanplakkal, Wei Wang, Jingmei Hsu, Maria T. Salpietro, Stephanie Banakis, Joshua Albert, Lars F. Westblade, Claudio Zanettini, Luigi Marchionni, Rosemary Soave, Elodie Ghedin, Diego G. Diel, Mirella Salvatore   +17 more
doaj   +1 more source