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SARS-CoV-2 viruso helikazės nsp13 mechanistiniai tyrimai

, 2023
In the face of still ongoing COVID-19 diagnoses and mortality rates around the world, the development of drugs capable of targeting all SARS-CoV-2 strains is crucial, given the constant mutations and potential emergence of more dangerous virus variants. To address this, identifying a conserved protein target that remains unaffected by variation between
openaire   +1 more source

SARS-CoV-2 Nsp13 helicase modulates miR-146a-mediated signaling pathways

Virology
Despite the successful development of vaccines and antiviral therapeutics against SARS-CoV-2, its tendency to mutate rapidly has emphasized the need for continued research to better understand this virus's mechanism of pathogenesis and interactions with host signaling pathways.
Eryn Lundrigan, Spencer Uguccioni, Christine Hum, Nadine Ahmed, John Paul Pezacki   +4 more
openaire   +2 more sources

Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir. [PDF]

Sci Adv
Rakib A, Das A, Bera SC, Cnossen J, Robles-Sikisaka R, Diefenbacher MV, America PPB, Klein M, Anderson TK, Marecki JC, Wang B, Bogers E, Feng JY, Bilello JP, Papini FS, Smitskamp Q, Sheahan TP, Arnold JJ, Routh A, Artsimovitch I, Kirchdoerfer RN, Cameron CE, Raney KD, Dulin D.   +23 more
europepmc   +1 more source

RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA. [PDF]

Cell Rep
America PPB, Bera SC, Das A, Anderson TK, Marecki JC, Papini FS, Arnold JJ, Kirchdoerfer RN, Cameron CE, Raney KD, Depken M, Dulin D.   +11 more
europepmc   +1 more source

A funnel approach to enable analyses of epitope-specific human CD4 T cells specific for influenza and SARS-CoV-2. [PDF]

mBio
Richards KA, Mettelman RC, Trombly K, Eismann M, Allen EK, Scott ZB, Joachimiak A, Schultz-Cherry S, Chaves FA, Thomas PG, Sant AJ.   +10 more
europepmc   +1 more source

Evolutionary inferences from the analysis of mutation dynamics in the SARS-CoV-2 replication-transcription complex. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Palyanov AY, Devyaterikov AP, Palyanova NV, Shestopalov AM.   +3 more
europepmc   +1 more source

Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites. [PDF]

J Biol Chem
Mingroni MA, Enney BM, Malsick LE, Geiss BJ.   +3 more
europepmc   +1 more source

Hippo signalling as a nexus in host-virus interactions. [PDF]

PLoS Pathog
Bahrami A, Walter C, Ardestani A.
europepmc   +1 more source

The regulatory mechanisms of SARS-CoV-2 N protein helicase and its annealing activity. [PDF]

iScience
Zhang B, Zhou P, Lan Z, Yang C, Li J, Zhang Y, Gao L, Wang H, Meng C, Wei S, Ruan C, Dai Y, Xie Y, Liu Y.   +13 more
europepmc   +1 more source

Protocol for the detection of RHIM-protein oligomeric complex formation using DSP-mediated crosslinking in HEK293T cultured cells. [PDF]

STAR Protoc
Mishra S, Dey AA, Kesavardhana S.
europepmc   +1 more source