Results 71 to 80 of about 3,842 (144)

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations

Journal of Traditional and Complementary Medicine, 2022
Background and aim: The ongoing global pandemic due to SARS-CoV-2 caused a medical emergency. Since December 2019, the COVID-19 disease is spread across the globe through physical contact and respiratory droplets.
Seshu Vardhan, Suban K. Sahoo
doaj   +1 more source

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba, Laura Hurtado‐Navarro, Diego Angosto‐Bazarra, Alberto Baroja‐Mazo, Pablo Pelegrin   +4 more
wiley   +1 more source

SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13

Frontiers in Microbiology, 2022
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2 proteins is important for drug design
Bo Zhang, Yan Xie, Zhaoling Lan, Dayu Li, Junjie Tian, Qintao Zhang, Hongji Tian, Jiali Yang, Xinnan Zhou, Shuyi Qiu, Keyu Lu, Yang Liu, Yang Liu   +12 more
doaj   +1 more source

Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern

SLAS Discovery
Several families of viruses encode helicase enzymes with essential roles in viral genome replication and transcription, including several RNA virus families of pandemic concern, such as coronaviruses and flaviviruses.
Nicole L. Inniss, Margarita Rzhetskaya, Ryan P. Kich, Elizabeth Gleason, Taha Y. Taha, Francisco J. Zapatero-Belinchón, Julia Rosecrans, Valentina Pedrero-Classen, Kenneth Huang, Gilles Degotte, Luca Lizzadro, Jason Pattie, Adam R. Renslo, George Minasov, Melanie Ott, Kelly E.R. Bachta, Karla J.F. Satchell, Judd F. Hultquist   +17 more
doaj   +1 more source

“Fertile” Mutations in SARS‐CoV‐2 RNA More Frequently Occurred in Hairpin Loops That Determine Virus Evolution

APMIS, Volume 133, Issue 12, December 2025.
ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson, Pierre Pontarotti, Jacques Fantini, Anthony Levasseur, Christian Devaux, Didier Raoult   +5 more
wiley   +1 more source

Molecular docking studies of some selected gallic acid derivatives against five non-structural proteins of novel coronavirus

Journal of Genetic Engineering and Biotechnology, 2021
Background The World Health Organization has recently declared a new coronavirus disease (COVID-19) a pandemic and a global health emergency. The pressure to produce drugs and vaccines against the ongoing pandemic has resulted in the use of some drugs ...
Haruna Isiyaku Umar, Bushra Siraj, Adeola Ajayi, Tajudeen O. Jimoh, Prosper Obed Chukwuemeka   +4 more
doaj   +1 more source

Cooperative Activity of SARS Coronavirus Nsp13 Helicase Characterized by Single Molecule FRET [PDF]

Biophysical Journal, 2015
SARS was epidemic in 2003 worldwide. SARS-CoV helicase plays critical roles in viral replication, and has been proposed to be a potential candidate for anti-SARS therapy. We use single molecule fluorescence resonance energy transfer to examine the unwinding and rewinding mechanism of nsP13 helicase on partial DNA duplexes as a function of protein, ATP ...
Im, Hyeryeon, Jee, Sangmi, Lee, Gwangrog
openaire   +1 more source

Implementation of a Multiplex PCR Amplification System Combined With Next‐Generation Genome Sequencing to Decipher the Circulation of Human Coronavirus 229E Lineages in Southern France

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Coronaviruses rapidly evolve and are prone to new virus emergence. Human coronavirus (HCoV)−229E is one of the seven coronaviruses (aside HCoV‐OC43, HCoV‐HKU1, HCoV‐NL63, SARS‐CoV, MERS‐CoV, SARS‐CoV‐2) causing respiratory infections in humans. Genomic data are very scarce for this virus.
Houmadi Hikmat, Justine Py, Céline Boschi, Emilie Burel, Lorlane Le Targa, Matthieu Million, Lucile Lesage, Aurélie Morand, Bernard La Scola, Philippe Colson   +9 more
wiley   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, Volume 12, Issue 37, October 6, 2025.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source