Results 31 to 40 of about 3,842 (144)

A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 Helicase. [PDF]

J Comput Chem
The new fragment‐based pharmacophore virtual screening workflow FragmentScout is introduced, which aggregates feature information present in each experimental fragment pose from XChem high‐throughput crystallographic screening. The method is applied to the SARS‐CoV‐2 NSP13 helicase, and we report the in silico discovery of 13 novel micromolar potent ...
Doijen J, Xie J, Marsili S, Bains T, Mann MK, Abeywickrema P, Van den Broeck N, Permann C, Langer T, Ibis G, Mattelaer CA, Harvey J, van Raalte S, Fino R, Pande V, Peeters D, Patrick A, Van Damme E, van Vlijmen H, Van Loock M, Jacoby E.   +20 more
europepmc   +2 more sources

Mechanism of duplex unwinding by coronavirus nsp13 helicases [PDF]

, 2020
Abstract The current COVID-19 pandemic urges in-depth investigation into proteins encoded with coronavirus (CoV), especially conserved CoV replicases. The nsp13 of highly pathogenic MERS-CoV, SARS-CoV-2, and SARS-CoV exhibit the most conserved CoV replicases.
Xiao Hu, Wei Hao, Bo Qin, Zhiqi Tian, Ziheng Li, Pengjiao Hou, Rong Zhao, Sheng Cui, Jiajie Diao   +8 more
openaire   +1 more source

Nucleotide-bound crystal structures of the SARS-CoV-2 helicase NSP13. [PDF]

Acta Crystallogr F Struct Biol Commun
Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP-bound model captures a state immediately following ATP hydrolysis, with both ADP and orthophosphate still present in the active site.
Kloskowski P, Neumann P, Berndt A, Ficner R.   +3 more
europepmc   +5 more sources

Coronaviruses SARS-CoV, MERS-CoV, and SARS-CoV-2 helicase inhibitors: a systematic review of in vitro studies

Journal of Virus Eradication, 2023
Introduction: The recent outbreak of SARS-CoV-2 has significantly increased the need to find inhibitors that target the essential enzymes for viral replication in host cells.
Nimer Mehyar
doaj   +1 more source

The NSP5, ORF6 and NSP13 of SARS-CoV-2 Cooperate to Modulate Inflammatory Cell Death Activation. [PDF]

Adv Sci (Weinh)
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Wang H, Liang M, Zhang J, Tong H, Zhang F, Liu Y, Wang P, Chang M, Han F, Liu S, Lin Y, Song W, Karki R, Wang P, Chen H, Liu Y, Zheng M.   +16 more
europepmc   +2 more sources

SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1

Cell & Bioscience, 2022
Background SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe COVID-19.
Sin-Yee Fung, Kam-Leung Siu, Huayue Lin, Ching-Ping Chan, Man Lung Yeung, Dong-Yan Jin   +5 more
doaj   +1 more source

The nsp1, nsp13, and M Proteins Contribute to the Hepatotropism of Murine Coronavirus JHM.WU [PDF]

Journal of Virology, 2015
ABSTRACT Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver.
Susan R. Weiss, Rong Zhang, Ralph S. Baric, Judith M. Phillips, Yize Li, Adam D. Steinbrenner, Boyd L. Yount, Timothy J. Cowley   +7 more
openaire   +3 more sources

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms.

PLoS ONE, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating global pandemic, infecting over 43 million people and claiming over 1 million lives, with these numbers increasing daily.
Christine Vazquez, Sydnie E Swanson, Seble G Negatu, Mark Dittmar, Jesse Miller, Holly R Ramage, Sara Cherry, Kellie A Jurado   +7 more
doaj   +1 more source

Five-Year (2017-2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next-Generation Sequencing. [PDF]

J Med Virol
ABSTRACT HCoV‐OC43 genomes and their evolution are scarcely studied worldwide and in France, with only 361 genomes available as of October 2023. Here, an in‐house PCR amplification system was implemented to obtain retrospectively by next‐generation sequencing, then analyze HCoV‐OC43 genomes for infections diagnosed with this virus in southern France ...
Houmadi H, Boschi C, Lefebvre M, Le Targa L, Py J, Lagier JC, Lesage L, Fantini J, Morand A, La Scola B, Colson P.   +10 more
europepmc   +2 more sources

SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation

Microorganisms, 2021
Viral infection-induced activation of inflammasome complexes has both positive and negative effects on the host. Proper activation of inflammasome complexes induces down-stream effector mechanisms that inhibit viral replication and promote viral ...
Na-Eun Kim, Dae-Kyum Kim, Yoon-Jae Song
doaj   +1 more source