Results 41 to 50 of about 3,842 (144)

An immunoinformatics approach to study the epitopes of SARS-CoV-2 helicase, Nsp13

Vacunas, 2023
Vaccines are administered worldwide to control on-going coronavirus disease-19 (COVID-19) pandemic caused by SARS-CoV-2. Vaccine efficacy is largely contributed by the epitopes present on the viral proteins and their alteration might help emerging variants to escape host immune surveillance.
Kumar, Sushant, Kumari, Khushboo, Azad, Gajendra Kumar   +2 more
openaire   +2 more sources

An immunoinformatics approach to study the epitopes contributed by Nsp13 of SARS-CoV-2 [PDF]

, 2021
ABSTRACT The on-going coronavirus disease-19 (COVID-19) pandemic caused by SARS-CoV-2 has infected hundreds of millions of people and killed more than two million people worldwide. Currently, there are no effective drugs available for treating SARS-CoV-2 infections; however, vaccines are now being administered worldwide to control this ...
Sushant Kumar, Gajendra Kumar Azad
openaire   +1 more source

Stalling the Enemy: Targeting Nsp13 for Next-Generation SARS-CoV-2 Antivirals. [PDF]

Int J Mol Sci
The SARS-CoV-2 public health challenges have highlighted the urgent need for coronavirus-targeting life-saving therapeutics. Given the emergence of drug-resistant strains, the development of antivirals against viral proteins beyond the commonly targeted main protease or RNA-dependent RNA polymerase is critical.
Castro JM, Slack RL, Ong YT, Zhang H, Gifford LB, Courouble VV, Aiken RM, Shankar V, O'Leary TR, Griffin PR, Lan S, Du Y, Fu H, Sarafianos SG.   +13 more
europepmc   +3 more sources

Antiviral Potential of Antillogorgia americana and elisabethae Natural Products against nsp16–nsp10 Complex, nsp13, and nsp14 Proteins of SARS-CoV-2: An In Silico Investigation

Microbiology Research, 2023
Biomolecules of marine origin have many applications in the field of biotechnology and medicine, but still hold great potential as bioactive substances against different diseases.
Omkar Pokharkar, Hariharan Lakshmanan, Grigory V. Zyryanov, Mikhail V. Tsurkan   +3 more
doaj   +1 more source

The role of ATP hydrolysis and product release in the translocation mechanism of SARS-CoV-2 nsp13

Biophysical Journal, 2023
Abstract In response to the emergence of COVID-19, caused by SARS-CoV-2, there has been a growing interest in understanding the functional mechanisms of the viral proteins to aid in the development of new therapeutics. Non-structural protein 13 (Nsp13) helicase is an attractive target for antivirals because it is essential for viral ...
Monsurat M. Lawal, Priti Roy, Martin McCullagh   +2 more
openaire   +3 more sources

Mapping major SARS-CoV-2 drug targets and assessment of druggability using computational fragment screening: Identification of an allosteric small-molecule binding site on the Nsp13 helicase.

PLoS ONE, 2021
The 2019 emergence of, SARS-CoV-2 has tragically taken an immense toll on human life and far reaching impacts on society. There is a need to identify effective antivirals with diverse mechanisms of action in order to accelerate preclinical development ...
Matthew R Freidel, Roger S Armen
doaj   +1 more source

Natural Compound ZINC12899676 Reduces Porcine Epidemic Diarrhea Virus Replication by Inhibiting the Viral NTPase Activity

Frontiers in Pharmacology, 2022
Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus (α-CoV) that causes high mortality in suckling piglets, leading to severe economic losses worldwide. No effective vaccine or commercial antiviral drug is readily available. Several replicative
Pengcheng Wang, Xianwei Wang, Xing Liu, Meng Sun, Xiao Liang, Juan Bai, Ping Jiang, Ping Jiang   +7 more
doaj   +1 more source

Therapeutic potential of compounds targeting SARS-CoV-2 helicase

Frontiers in Chemistry, 2022
The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the SARS-CoV-2 helicase (nsp13) does ...
Matthew T. J. Halma, Matthew T. J. Halma, Mark J. A. Wever, Mark J. A. Wever, Sanne Abeln, Didier Roche, Gijs J. L. Wuite   +6 more
doaj   +1 more source

Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach

Molecules, 2022
The SARS-CoV-2 non-structural protein 13 (nsp13) helicase is an essential enzyme for viral replication and has been identified as an attractive target for the development of new antiviral drugs.
Isabella Romeo, Francesca Alessandra Ambrosio, Giosuè Costa, Angela Corona, Mohammad Alkhatib, Romina Salpini, Saverio Lemme, Davide Vergni, Valentina Svicher, Maria Mercedes Santoro, Enzo Tramontano, Francesca Ceccherini-Silberstein, Anna Artese, Stefano Alcaro   +13 more
doaj   +1 more source

Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase

Journal of Biomolecular Structure and Dynamics, 2021
The rise in the incidence of COVID-19 as a result of SARS-CoV-2 infection has threatened public health globally. Till now, there have been no proper prophylactics available to fight COVID-19, necessitating the advancement and evolution of effective curative against SARS-CoV-2.
Rajat, Nandi, Deep, Bhowmik, Rakesh, Srivastava, Amresh, Prakash, Diwakar, Kumar   +4 more
openaire   +2 more sources