Results 191 to 200 of about 7,665 (202)

Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3

Journal of Virology
Porcine deltacoronavirus (PDCoV) is a potential emerging zoonotic pathogen, and studies on the prevalence and pathogenesis of PDCoV are ongoing. The main protease (nsp5) of PDCoV provides an excellent target for antivirals due to its essential and conserved function in the viral replication cycle.
Haixin Huang, Xiaoxiao Lei, Chenchen Zhao, Yan Qin, Yuying Li, Xinyu Zhang, Chengkai Li, Tian Lan, Baopeng Zhao, Wenchao Sun, Huijun Lu, Ningyi Jin   +11 more
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Expression and Purification of Rotavirus Proteins NSP5 and NSP6 in Escherichia coli

Cell Biochemistry and Biophysics, 2006
Rotaviruses are one of the worldwide leading causes of gastroenteritis in children under 5 yr old. The rotavirus nonstructural NSP5 is a phosphoprotein implicated in viroplasms formation, whereas NSP6 could have a possible regulatory role of NSP5. It has been reported that N- and C-termini of NSP5 are important for their function.
M, Samaniego-Hernández, A, De León-Rodriguez, R, Aparicio-Fabre, C, Arias-Ortiz, A P, Barba de la Rosa   +4 more
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The Role of nsp5 in SARS-CoV-2

Theoretical and Natural Science
SARS-CoV-2, the causative agent of the COVID-19 pandemic, is a single-stranded positive-sense RNA virus belonging to the coronavirus family. It emerged at the end of 2019 and has swiftly disseminated globally, presenting an unparalleled threat to public health worldwide.
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[NSP5/NSP6 of rotavirus strain TB-Chen and preliminary genotyping analysis].

Bing du xue bao = Chinese journal of virology, 2010
Strain TB-Chen is a group A rotavirus (RV) isolated from a Chinese infant suffering from gastroenteritis in hospital. The NSP5 and NSP6 of strain TB-Chen are encoded by the 10th gene segment (816bp in whole length) of the viral genome. The results obtained in this study showed that the NSP5 was encoded in the first open-reading-frame (ORF) of the gene ...
Yu-Ling, Wen, Chuan-Yin, Li, Yao-Chun, Fan, Yan, Zhang, Hai-Tao, Wei, Yuan-Ding, Chen   +5 more
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Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19

Journal of General Virology, 2021
Nathan Junod, Dia Beachboard, Christopher C Stobart   +2 more
exaly  

SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its SARS-CoV Ortholog

Journal of Virology, 2022
junwei zhou, Gui-Qing Peng, Dang Wang
exaly  

SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

MBio, 2021
Youliang Rao, Shu Zhang, Jessica Carriere   +2 more
exaly  

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Antiviral Research, 2022
Emna Harigua-Souiai, Sylvain Paisant, Arnaud Blondel   +2 more
exaly  

Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories

Journal of Virology, 2019
Guido Papa, Francesca Arnoldi, Elisabeth M Schraner   +2 more
exaly  

Characterization of SARS-CoV-2 protease NSP3 and NSP5 degradome.

Infectious diseases are serious threats to human health and economy in both developed and non-developed countries. They are the cause of approximately half of the death toll worldwide. Recently, a severe acute respiratory syndrome, named COVID-19 (coronavirus disease 2019), has spread across the globe and has been found to be caused by a novel strain ...
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