Results 41 to 50 of about 6,777,214 (229)

Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter [PDF]

, 1967
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Brunak, Søren, Halasz, Melinda, Huber, Kilian V.M., Kolch, Walter, Papamarkou, Theodore, Radic-Sarikas, Branka, Superti-Furga, Giulio, Tsafou, Kalliopi P., Winter, Georg E.   +8 more
core   +3 more sources

Investigation of a Novel NTRK1 Variation Causing Congenital Insensitivity to Pain With Anhidrosis

Frontiers in Genetics, 2021
Background: Congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive sensory neuropathy, was caused mainly by biallelic mutations in the NTRK1 gene.
Kai Yang, Yi-Cheng Xu, Hua-Ying Hu, Ya-Zhou Li, Qian Li, Ying-Yi Luan, Yan Liu, Yong-Qing Sun, Zhan-Ke Feng, You-Sheng Yan, Cheng-Hong Yin   +10 more
doaj   +1 more source

BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer [PDF]

, 2009
Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, RET and neurotrophic tyrosine kinase receptor type I (NTRK1)
Baumgartner, Adolf, Kwan, Johnson, Lu, Chun-Mei, Wang, Mei, Weier, Heinz-Ulrich G., Weier, Jingly F., Zitzelsberger, Horst F.   +6 more
core   +2 more sources

Targeted Therapy Using the Selective Tropomyosin Kinase Receptor Inhibitor Larotrectinib in an Infant with Infantile Fibrosarcoma with a TPM3–NTRK1 Gene Fusion with Lung and Central Nervous System Metastases: Case Report

, 2021
This case report describes the outcomes of tropomyosin receptor kinase (TRK) inhibitor treatment in an infant with an infantile fibrosarcoma (IFS) with a TPM3–NTRK1 gene fusion.
E. Caran, F. Romagnol, S. Cavalheiro, M. Petrilli, H. Lederman, Fernanda Teresa de Lima, M. T. Alves, L. Carreira, A. Petrilli   +8 more
semanticscholar   +1 more source

Clinical features for diagnosis and management of patients with PRDM12 congenital insensitivity to pain. [PDF]

, 2016
BACKGROUND: Congenital insensitivity to pain (CIP) is a rare extreme phenotype characterised by an inability to perceive pain present from birth due to lack of, or malfunction of, nociceptors.
Ahmed, Mushtaq, Bennett, Christopher, Chen, Ya-Chun, Sharif, Saghira Malik, Sheridan, Eamonn, Valente, Enza-Maria, Woods, Geoffrey, Zhang, Stella   +7 more
core   +3 more sources

A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis

BMC Medical Genetics, 2011
Background Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis.
Arístegui Javier, Garrote Elisa, Rodríguez Jose A, Sarasola Esther, García-Barcina Maria J   +4 more
doaj   +1 more source

Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy

Oncogenesis, 2023
The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as pan-tumor oncogenic drivers has led to new personalized therapies in oncology.
Fabio Vanoli, Laurie Herviou, Yusuke Tsuda, Patricia Sung, Ziyu Xie, Eve Fishinevich, Soe S. Min, William Mallen, Henry de Traux de Wardin, Yanming Zhang, Maria Jasin, Cristina R. Antonescu   +11 more
doaj   +1 more source

Area Postrema [PDF]

, 2008
This report contains a gene expression summary of the area postrema (AP), derived from the "Allen Brain Atlas":http://www.brain-map.org/welcome.do;jsessionid=EDE40ADC940845D169DE378ADC9B71BD (ABA) in-situ hybridization (ISH) mouse data set ...
Allen Institute for Brain Science, John A. Morris, Katie J. Glattfelder, Lydia L. Ng   +3 more
core   +2 more sources

Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice

Translational Psychiatry, 2020
Previously, we reported a family in which bipolar disorder (BD) co-segregates with a Mendelian kidney disorder linked to 1q22. The causative renal gene was later identified as MUC1.
Kazuo Nakajima, Alannah Miranda, David W. Craig, Tatyana Shekhtman, Stanislav Kmoch, Anthony Bleyer, Szabolcs Szelinger, Tadafumi Kato, John R. Kelsoe   +8 more
doaj   +1 more source

Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion [PDF]

, 2018
In recent years, undifferentiated small round cell sarcomas (USRCSs) have been divided into a variety of new, rare, sarcoma subtypes, including the group of Ewing-like sarcomas, which have the morphological appearance of Ewing sarcomas, but carry CIC ...
Antonescu, Antonescu, Bray, Brohl, Cellier, Clark, Conkright, Dobin, Enlund, Ge, Haas, Iourgenko, Kawamura-Saito, Machado, Middeljans, Nielsen, Nordkvist, Pierron, Puls, R Development Core Team, Schram, Skytting, Specht, Sugita, Tirado, Tonon   +25 more
core   +3 more sources