Results 61 to 70 of about 2,522,601 (164)
Frontiers in GeneticsBackgroundCongenital insensitivity to pain with anhidrosis (CIPA, OMIM #256800), also known as hereditary sensory and autonomic neuropathy type Ⅳ (HSAN-IV), is a rare autosomal recessive disorder characterized by recurrent episodic fevers, anhidrosis ...
Ling Sun +10 more
doaj +1 more source
Nature Communications, 2017 The use of mouse models has been an invaluable resource in cancer research but their generation is lengthy and costly. Here the authors describe an approach to generate engineered mouse models carrying specific gene fusions and, as a proof of principle ...
Peter J. Cook +8 more
doaj +1 more source
More Than a Birthmark? A Growing Pediatric Skin Lesion
JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj +2 more
wiley +1 more source
Tumorigenic activities of NFASC-NTRK1 fusion gene.
, 2014 (A) NFASC-NTRK1 and EGFR vIII mRNA expression in NIH 3T3 cells, determined by RT-PCR. (B) Proliferation of NIH 3T3 cells lentivirally infected with the indicated viruses. Error bars are 95% confidence intervals.
Hee-Jin Cho (539376) +8 more
core +1 more source
NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors
Communications Biology, 2020 Romel Somwar et al. find that cancer-causing NTRK gene fusions resistant to one form of inhibitor therapy can be resistant to other inhibitor types.
Romel Somwar +14 more
doaj +1 more source
Cancer Innovation, Volume 5, Issue 4, August 2026.Radioiodine‐refractory differentiated thyroid cancer (RAIR‐DTC) management now spans selective kinase inhibitors, MAPK‐pathway redifferentiation, VEGFR multikinase TKIs, and biomarker‐driven immunotherapy. We propose a three‐axis decision framework integrating molecular driver, evidence level, and patient dimension to guide individualized treatment ...
Yamin Li, Zuoxiang He
wiley +1 more source
Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers
, 2017 Neurotrophic receptor tyrosine kinase 1 (NTRK1) gene rearrangement leads to constitutive activation of NTRK1, which induces high-transforming ability. NTRK-rearranged cancers have been identified in several cancer types, such as glioblastoma, non–small ...
Naoya Fujita +5 more
core +1 more source
MEIS1::NCOA2 Rearranged Spindle Cell Neoplasm of Vulva With Unusual Low‐Grade Morphology
Genes, Chromosomes and Cancer, Volume 65, Issue 8, August 2026.ABSTRACT MEIS1::NCOA2 is a recurrent gene fusion that has been predominantly identified in primitive sarcomas arising within the genitourinary and gynecological tracts. Since its initial description in 2018, an increasing number of cases have been reported, further defining the clinicopathological spectrum of this entity.
Pinki Soni +6 more
wiley +1 more source
, 2021 Background: Congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive sensory neuropathy, was caused mainly by biallelic mutations in the NTRK1 gene.
Hua-Ying Hu (11797217) +10 more
core +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Maximus CF Yeung +4 more
wiley +1 more source