Results 71 to 80 of about 2,522,601 (164)

Analysis of NTRK1 gene rearrangement and BRAF gene mutation in papillary thyroid carcinoma

, 2004
Activating mutations of genes coding for two different tyrosine kinase receptor, either RET or NTRK1 (also named TRKA), as well as of RAS or BRAF gene are associated with human thyroid papillary carcinoma (PTC).
Li, Chun-Liang
core  

Generalized eruptive histiocytosis associated with a novel fusion in LMNA-NTRK1 [PDF]

, 2016
Non-Langerhans cell histiocytosis (NLCH) is a histiocyte disorder comprised of dermal dendritic histiocytes with a characteristic staining pattern.
Jahan-Tigh, Richard R, Chon, Susan, Pinney, Sarah S   +2 more
core   +1 more source

NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas

Pathology and Oncology Research
The neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins.
Zoltán Lippai, Gergő Papp, Károly Szuhai, Johanna Sápi, Katalin Dezső, Zoltán Sápi   +5 more
doaj   +1 more source

Lipofibromatosis-like neural tumor: Case report of a unique infantile presentation

JAAD Case Reports, 2018
A 14-month-old boy presented with a slow-growing, asymptomatic back plaque, which was biopsied and found to have S100 positivity, sparse CD34 staining, and no significant mitotic activity, nuclear pleomorphism, or necrosis; genetic workup found LMNA ...
Diana W. Bartenstein, BA, Taylor M. Coe, MD, Samantha C. Gordon, MD, Alison M. Friedmann, MD, Maryanne M. Senna, MD, Cassandra M. Kelleher, MD, Cristina R. Antonescu, MD, Rosalynn M. Nazarian, MD, Elena B. Hawryluk, MD, PhD   +8 more
doaj   +1 more source

Novel pathogenic mechanisms of CIPA genetic disorder unveiled by functional analysis of NTRK1/NGF receptor mutations

, 2002
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare genetic disease characterized by absence of reaction to noxious stimuli and anhidrosis. The genetic bases of CIPA have remained long unknown.
SELLERI S, Pagliardini, S., GRECO A., MIRANDA C, Pierotti, M.A., ZANOTTI, GIUSEPPE, DIO VIRGILIO M, PIEROTTI M. A, Miranda, C., Selleri, S., Greco, A., Di Virgilio, M., Zanotti, G., PAGLIARDINI S   +13 more
core   +1 more source

Prevalence of neurotrophic tropomyosin receptor kinase (NTRK) fusion gene positivity in patients with solid tumors in Japan

Cancer Medicine
Background Members of the neurotrophic tropomyosin receptor kinase (NTRK) gene family, NTRK1, NTRK2, and NTRK3 encode TRK receptor tyrosine kinases. Intra‐ or inter‐chromosomal gene rearrangements produce NTRK gene fusions encoding fusion proteins which ...
Eiji Nakata, Tatsunori Osone, Toru Ogawa, Tomoyuki Taguchi, Kana Hattori, Shinji Kohsaka   +5 more
doaj   +1 more source

NTRK-rearranged spindle cell neoplasm of the female genital tract: case report and literature review

Frontiers in Oncology
NTRK-rearranged spindle cell neoplasm is a rare subtype of soft tissue sarcoma that occasionally arises in the lower female genital tract. Accurate diagnosis is clinically important, as these tumors generally display low-grade malignant behavior and may ...
Lulu Feng, Lulu Feng, Lei Li, Lei Li, Yanmei He, Yanmei He, Wei Jiang, Wei Jiang   +7 more
doaj   +1 more source

Molecular genetic characterization reveals linear tumor evolution in a pulmonary sarcomatoid carcinomas patient with a novel PHF20-NTRK1 fusion: a case report

BMC Cancer, 2019
Background Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonary SC develops and progresses. Case
Jianjun Ge, Bin Yao, Jia Huang, Xue Wu, Hua Bao, Qiuxiang Ou, Yang W. Shao, Jun Chen   +7 more
doaj   +1 more source

List of drugs that target NTRK1.

Human kinases play essential and diverse roles in the cellular activities of maintaining homeostasis and growth. Genetic mutations in the genes encoding the kinases (or phosphotransferases) have been linked with various types of cancers.
Muhammad Shakeel (509491), Salman Ahmed Khan (18404340), Daniel C. Hoessli (11237454), Misbah Anwar (18404343), Ambrina Khatoon (16319200), Moom R. Roosan (10167004), Atia Gohar (16712961)   +6 more
core   +1 more source

Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient [PDF]

, 2017
In colorectal cancer patients, chromosomal rearrangements involving NTRK1 gene (encoding the TRKA protein) are shown in a small subset of patients and are associated with the constitutive activation of the kinase domain of TRKA.
Massimo Milione, S. Siena, G. Fucà, Silvio Veronese, Danielle Murphy, Filippo De Braud, E. Ardini, A. Testi, Adele Testi, Emanuele Valtorta, Elena Ardini, J. Christiansen, F. De Braud, Giovanni Fucà, Ge Wei, S. Veronese, G. Wei, Alessio Pellegrinelli, Filippo Pietrantonio, A. Isacchi, Antonella Isacchi, A. Pellegrinelli, Roberta Bosotti, F. Pietrantonio, E. Valtorta, Salvatore Siena, Jason Christiansen, M. Milione, R. Bosotti, D. Murphy   +29 more
core   +1 more source