Results 51 to 60 of about 31,361 (244)

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress [PDF]

Current Opinion in Cell Biology, 2017
Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding ...
Ming F, Lye, Adrian R, Wilkie, David J, Filman, James M, Hogle, Donald M, Coen   +4 more
openaire   +2 more sources

Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress [PDF]

Journal of Virology, 2014
ABSTRACT Herpesviruses have evolved a unique mechanism for nuclear egress of nascent progeny nucleocapsids: the nucleocapsids bud through the inner nuclear membrane into the perinuclear space between the inner and outer nuclear membranes (primary envelopment), and enveloped nucleocapsids then fuse with the outer nuclear membrane to release ...
Zhuoming, Liu, Akihisa, Kato, Keiko, Shindo, Takeshi, Noda, Hiroshi, Sagara, Yoshihiro, Kawaoka, Jun, Arii, Yasushi, Kawaguchi   +7 more
openaire   +2 more sources

Nuclear Envelope Breakdown Can Substitute for Primary Envelopment-Mediated Nuclear Egress of Herpesviruses [PDF]

Journal of Virology, 2011
ABSTRACT Herpesvirus nucleocapsids assemble in the nucleus but mature to infectious virions in the cytoplasm. To gain access to this cellular compartment, nucleocapsids are translocated to the cytoplasm by primary envelopment at the inner nuclear membrane and subsequent fusion of the primary envelope with the outer nuclear membrane.
Barbara G, Klupp, Harald, Granzow, Thomas C, Mettenleiter   +2 more
openaire   +2 more sources

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97

Viruses, 2018
The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress.
Jens Milbradt, Eric Sonntag, Sabrina Wagner, Hanife Strojan, Christina Wangen, Tihana Lenac Rovis, Berislav Lisnic, Stipan Jonjic, Heinrich Sticht, William J. Britt, Ursula Schlötzer-Schrehardt, Manfred Marschall   +11 more
doaj   +1 more source

The eclipsing X-ray pulsar X-7 in M33 [PDF]

, 1998
Using our extensive ROSAT X-ray observations of M33, we confirm a 3.45 day eclipse period for the Einstein source X-7 (Larson & Schulman, 1997) and discover evidence for a 0.31-s pulse period.
Brazier, David, de Vaucouleurs, Dubus, E. Kuulkers, Eggleton, G. Dubus, Humphreys, K. S. Long, Larson, Leahy, Long, Long, Markert, P. A. Charles, P. J. Hakala, Peres, Schulman, Schulman, Schulman, Trinchieri, Trümper, van den Bergh, van der Klis, van Paradijs, White   +25 more
core   +3 more sources

Quantitative Microscopy Reveals Stepwise Alteration of Chromatin Structure during Herpesvirus Infection

Viruses, 2019
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm.
Vesa Aho, Elina Mäntylä, Axel Ekman, Satu Hakanen, Salla Mattola, Jian-Hua Chen, Venera Weinhardt, Visa Ruokolainen, Beate Sodeik, Carolyn Larabell, Maija Vihinen-Ranta   +10 more
doaj   +1 more source

Conquering the Nuclear Envelope Barriers by EBV Lytic Replication

Viruses, 2021
The nuclear envelope (NE) of eukaryotic cells has a highly structural architecture, comprising double lipid-bilayer membranes, nuclear pore complexes, and an underlying nuclear lamina network.
Chung-Pei Lee, Mei-Ru Chen
doaj   +1 more source

When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

Viruses, 2021
The proper assembly and dissemination of progeny virions is a fundamental step in virus replication. As a whole, viruses have evolved a myriad of strategies to exploit cellular compartments and mechanisms to ensure a successful round of infection.
Kevin M. Rose, Stephanie J. Spada, Vanessa M. Hirsch, Fadila Bouamr   +3 more
doaj   +1 more source

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling [PDF]

, 2011
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling.
Abdi, Agarwal, Allen, Anamika, Behnke, Billker, Billker, Bishop, Blethrow, Bracchi-Ricard, Bradley, Brian M. Cooke, Butcher, Carruthers, Carvalho, Christian Doerig, Cooke, Cooke, Coppi, Dalpke, Daniel C. Lim, Dar, Doerig, Doerig, Doerig, Dorin, Dorin, Dorin, Droucheau, El Hajj, Fennell, Fentress, Gilbert, Green, Gueirard, Halbert, Hanks, Huse, Hutti, Ishino, Jensen, Jeroen P.J. Saeij, Kafsack, Kannan, Kato, Khaminets, Khan, Khan, Khan, Kieschnick, Kun, Kuo, Labesse, Ling, Lodoen, Lourido, Luder, Manning, Martens, Melzer, Nagamune, Nunes, Nunes, Ojo, Ong, Parsons, Peixoto, Pernas, Qiu, Reese, Reese, Reese, Reininger, Reininger, Reininger, Rosenberg, Rosowski, Saeij, Saeij, Scheibel, Schneider, Shiels, Sicard, Singh, Singh, Solyakov, Sopko, Steinfeldt, Sugi, Suss-Toby, Taylor, Taylor, Tewari, Vaid, van de Sand, Ward, Ward, Wernimont, Wernimont, Xu, Yamamoto, Yasukawa, Zeqiraj, Zeqiraj, Zhao, Zhao   +105 more
core   +2 more sources

Neural regulation of cancer: from mechanobiology to inflammation. [PDF]

, 2016
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung, Rowat, Amy C, Sloan, Erica K   +2 more
core   +2 more sources