Results 41 to 50 of about 13,358 (220)

NECing goes: flexibility of the herpesvirus nuclear egress complex

, 2023
Abstract The nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which bud into the perinuclear space.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp B, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +2 more sources

The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses [PDF]

Journal of Virology, 2015
ABSTRACT Herpesviruses are unusual among enveloped viruses because they bud twice yet acquire a single envelope. They are also the only known viruses that bud into the nuclear envelope. We discovered that the herpesvirus nuclear egress complex could bud membranes without the help of other proteins by forming a coat-like hexagonal scaffold ...
Janna M, Bigalke, Ekaterina E, Heldwein
openaire   +2 more sources

Quantitative Microscopy Reveals Stepwise Alteration of Chromatin Structure during Herpesvirus Infection

Viruses, 2019
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm.
Vesa Aho, Elina Mäntylä, Axel Ekman, Satu Hakanen, Salla Mattola, Jian-Hua Chen, Venera Weinhardt, Visa Ruokolainen, Beate Sodeik, Carolyn Larabell, Maija Vihinen-Ranta   +10 more
doaj   +1 more source

Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress [PDF]

Journal of Virology, 2014
ABSTRACT Herpesviruses have evolved a unique mechanism for nuclear egress of nascent progeny nucleocapsids: the nucleocapsids bud through the inner nuclear membrane into the perinuclear space between the inner and outer nuclear membranes (primary envelopment), and enveloped nucleocapsids then fuse with the outer nuclear membrane to release ...
Zhuoming, Liu, Akihisa, Kato, Keiko, Shindo, Takeshi, Noda, Hiroshi, Sagara, Yoshihiro, Kawaoka, Jun, Arii, Yasushi, Kawaguchi   +7 more
openaire   +2 more sources

Conquering the Nuclear Envelope Barriers by EBV Lytic Replication

Viruses, 2021
The nuclear envelope (NE) of eukaryotic cells has a highly structural architecture, comprising double lipid-bilayer membranes, nuclear pore complexes, and an underlying nuclear lamina network.
Chung-Pei Lee, Mei-Ru Chen
doaj   +1 more source

When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

Viruses, 2021
The proper assembly and dissemination of progeny virions is a fundamental step in virus replication. As a whole, viruses have evolved a myriad of strategies to exploit cellular compartments and mechanisms to ensure a successful round of infection.
Kevin M. Rose, Stephanie J. Spada, Vanessa M. Hirsch, Fadila Bouamr   +3 more
doaj   +1 more source

Human Cytomegalovirus pUL93 Links Nucleocapsid Maturation and Nuclear Egress [PDF]

Journal of Virology, 2016
ABSTRACT Human cytomegalovirus (HCMV) pUL93 and pUL77 are both essential for virus growth, but their functions in the virus life cycle remain mostly unresolved. Homologs of pUL93 and pUL77 in herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV) are known to interact to form a complex at capsid vertices known as the capsid vertex ...
Bernadette M, DeRussy, Molly T, Boland, Ritesh, Tandon   +2 more
openaire   +2 more sources

Membrane deformation and scission by the HSV-1 nuclear egress complex [PDF]

Nature Communications, 2014
The nuclear egress complex (NEC) of herpesviruses such as HSV-1 is essential for the exit of nascent capsids from the cell nucleus. The NEC drives nuclear envelope vesiculation in cells, but the precise budding mechanism and the potential involvement of cellular proteins are unclear.
Bigalke, Janna M., Heuser, Thomas, Nicastro, Daniela, Heldwein, Ekaterina E.   +3 more
openaire   +2 more sources

Primary envelopment of Kaposi’s sarcoma-associated herpesvirus at the nucleoplasmic reticulum

Journal of Virology
Herpesvirus egress begins with primary envelopment of newly assembled capsids at the inner nuclear membrane (INM). Primary envelopment has been observed at the peripheral INM as well as nuclear infoldings. Nuclear infoldings from invaginations of the INM
Alexa Wilson, Neale D. Ridgway, Craig McCormick   +2 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source