Results 41 to 50 of about 31,285 (260)

Venture from the Interior—Herpesvirus pUL31 Escorts Capsids from Nucleoplasmic Replication Compartments to Sites of Primary Envelopment at the Inner Nuclear Membrane

Cells, 2017
Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress.
Susanne M. Bailer
doaj   +1 more source

The nuclear egress complex of MHV-68 is not essential for nuclear egress but mediates C-capsid specificity

AbstractHerpesvirus capsids must exit the nucleus to undergo additional maturation steps in the cytoplasm, such as secondary envelopment. This process is orchestrated by the nuclear egress complex (NEC), a conserved heterodimer that deforms the inner nuclear membrane and facilitates capsid egress.
Sanders S, Schneider C, Soh TK, Kotova E, Steer B, Reimer R, Ruzsics Z, Adler H, Bosse JB.   +8 more
europepmc   +2 more sources

NECing goes: flexibility of the herpesvirus nuclear egress complex

, 2023
AbstractThe nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which bud into the perinuclear space.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp B, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +2 more sources

Human Cytomegalovirus UL97 Phosphorylates the Viral Nuclear Egress Complex [PDF]

Journal of Virology, 2015
ABSTRACT Herpesvirus nucleocapsids exit the host cell nucleus in an unusual process known as nuclear egress. The human cytomegalovirus (HCMV) UL97 protein kinase is required for efficient nuclear egress, which can be explained by its phosphorylation of the nuclear lamina component lamin A/C, which disrupts the nuclear lamina.
Sharma, Mayuri, Bender, Brian, Kamil, Jeremy, Lye, Ming, Pesola, Jean, Reim, Natalia, Hogle, James, Coen, Donald   +7 more
openaire   +3 more sources

Vesicular Nucleo-Cytoplasmic Transport—Herpesviruses as Pioneers in Cell Biology

Viruses, 2016
Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm.
Thomas C. Mettenleiter
doaj   +1 more source

Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions

Viruses, 2021
The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked ...
Veronica Sanchez, William Britt
doaj   +1 more source

Functional Domains of Murine Cytomegalovirus Nuclear Egress Protein M53/p38 [PDF]

Journal of Virology, 2006
ABSTRACT Two conserved herpes simplex virus 1 proteins, UL31 and UL34, form a complex at the inner nuclear membrane which governs primary envelopment and nuclear egress of the herpesvirus nucleocapsids. In mouse cytomegalovirus, a member of the betaherpesvirus subfamily, the homologous proteins M53/p38 and M50/p35 form the ...
Mark, Lötzerich, Zsolt, Ruzsics, Ulrich H, Koszinowski   +2 more
openaire   +3 more sources

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress [PDF]

Current Opinion in Cell Biology, 2017
Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding ...
Ming F, Lye, Adrian R, Wilkie, David J, Filman, James M, Hogle, Donald M, Coen   +4 more
openaire   +2 more sources

The eclipsing X-ray pulsar X-7 in M33 [PDF]

, 1998
Using our extensive ROSAT X-ray observations of M33, we confirm a 3.45 day eclipse period for the Einstein source X-7 (Larson & Schulman, 1997) and discover evidence for a 0.31-s pulse period.
Brazier, David, de Vaucouleurs, Dubus, E. Kuulkers, Eggleton, G. Dubus, Humphreys, K. S. Long, Larson, Leahy, Long, Long, Markert, P. A. Charles, P. J. Hakala, Peres, Schulman, Schulman, Schulman, Trinchieri, Trümper, van den Bergh, van der Klis, van Paradijs, White   +25 more
core   +3 more sources

Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress [PDF]

Journal of Virology, 2014
ABSTRACT Herpesviruses have evolved a unique mechanism for nuclear egress of nascent progeny nucleocapsids: the nucleocapsids bud through the inner nuclear membrane into the perinuclear space between the inner and outer nuclear membranes (primary envelopment), and enveloped nucleocapsids then fuse with the outer nuclear membrane to release ...
Zhuoming, Liu, Akihisa, Kato, Keiko, Shindo, Takeshi, Noda, Hiroshi, Sagara, Yoshihiro, Kawaoka, Jun, Arii, Yasushi, Kawaguchi   +7 more
openaire   +2 more sources