Results 41 to 50 of about 1,436,031 (236)
Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus. [PDF]
J Virol, 2019 Increasing amounts of knowledge indicate that the nuclear egress complex (NEC) is critical for the nuclear egress of herpesvirus capsids, which can be viewed as a vesicle-mediated transport pathway through the nuclear membrane. In this study, we identified open reading frame 67 (ORF67) and ORF69 as components of the NEC in murine gammaherpesvirus 68 ...
Lv Y +6 more
europepmc +4 more sources
The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. [PDF]
PLoS Pathogens, 2015 Progeny capsids of herpesviruses leave the nucleus by budding through the nuclear envelope. Two viral proteins, the membrane protein pUL34 and the nucleo-phosphoprotein pUL31 form the nuclear egress complex that is required for capsid egress out of the ...
Christina Funk +7 more
doaj +1 more source
Abstract Herpesvirus capsids must exit the nucleus to undergo additional maturation steps in the cytoplasm, such as secondary envelopment. This process is orchestrated by the nuclear egress complex (NEC), a conserved heterodimer that deforms the inner nuclear membrane and facilitates capsid egress.
Sanders S +8 more
europepmc +2 more sources
Getting to and through the inner nuclear membrane during herpesvirus nuclear egress [PDF]
Current Opinion in Cell Biology, 2017 Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding ...
Ming F, Lye +4 more
openaire +2 more sources
Viruses, 2020 Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellular ...
Manfred Marschall +12 more
doaj +1 more source
Nuclear envelope budding and its cellular functions
Nucleus, 2023 The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Katharina S. Keuenhof +6 more
doaj +1 more source
Cells, 2017 Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress.
Susanne M. Bailer
doaj +1 more source
Vesicular Nucleo-Cytoplasmic Transport—Herpesviruses as Pioneers in Cell Biology
Viruses, 2016 Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm.
Thomas C. Mettenleiter
doaj +1 more source
The processes mediating capsid trafficking during human cytomegalovirus nuclear egress
, 2019 Herpesviruses are widespread pathogens that cause or contribute to an array of human diseases. Viral DNA synthesis, capsid assembly, and packaging occur in nucleoplasmic structures called replication compartments (RCs), after which capsids transit to the
Wilkie, Adrian R.
core +4 more sources
Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]
, 2008 Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core +1 more source