Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]
, 2004 Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry +7 more
core +1 more source
Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions
Viruses, 2021 The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked ...
Veronica Sanchez, William Britt
doaj +1 more source
Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus [PDF]
, 2016 Although the mechanism is not well understood, growing evidence indicates that the nonenveloped parvovirus minute virus of mice (MVM) may actively egress before passive release through cell lysis.
Wolfisberg, Raphael +2 more
core +1 more source
The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses [PDF]
Journal of Virology, 2015 ABSTRACT Herpesviruses are unusual among enveloped viruses because they bud twice yet acquire a single envelope. They are also the only known viruses that bud into the nuclear envelope. We discovered that the herpesvirus nuclear egress complex could bud membranes without the help of other proteins by forming a coat-like hexagonal scaffold ...
Janna M, Bigalke, Ekaterina E, Heldwein
openaire +2 more sources
Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress [PDF]
Current Biology, 2018 Viruses that replicate in the host cell nucleus face challenges in usurping cellular pathways to enable passage through the nuclear envelope [1]. Baculoviruses are enveloped, double-stranded DNA viruses that infect lepidopteran insects and are tools for protein expression, cell transduction, and pest management [2-4].
Ohkawa, Taro, Welch, Matthew D
openaire +4 more sources
Viruses, 2019 During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm.
Vesa Aho +10 more
doaj +1 more source
Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress [PDF]
Journal of Virology, 2014 ABSTRACT Herpesviruses have evolved a unique mechanism for nuclear egress of nascent progeny nucleocapsids: the nucleocapsids bud through the inner nuclear membrane into the perinuclear space between the inner and outer nuclear membranes (primary envelopment), and enveloped nucleocapsids then fuse with the outer nuclear membrane to release ...
Zhuoming, Liu +7 more
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Conquering the Nuclear Envelope Barriers by EBV Lytic Replication
Viruses, 2021 The nuclear envelope (NE) of eukaryotic cells has a highly structural architecture, comprising double lipid-bilayer membranes, nuclear pore complexes, and an underlying nuclear lamina network.
Chung-Pei Lee, Mei-Ru Chen
doaj +1 more source
Human Cytomegalovirus pUL93 Links Nucleocapsid Maturation and Nuclear Egress [PDF]
Journal of Virology, 2016 ABSTRACT Human cytomegalovirus (HCMV) pUL93 and pUL77 are both essential for virus growth, but their functions in the virus life cycle remain mostly unresolved. Homologs of pUL93 and pUL77 in herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV) are known to interact to form a complex at capsid vertices known as the capsid vertex ...
Bernadette M, DeRussy +2 more
openaire +2 more sources
Membrane deformation and scission by the HSV-1 nuclear egress complex [PDF]
Nature Communications, 2014 The nuclear egress complex (NEC) of herpesviruses such as HSV-1 is essential for the exit of nascent capsids from the cell nucleus. The NEC drives nuclear envelope vesiculation in cells, but the precise budding mechanism and the potential involvement of cellular proteins are unclear.
Bigalke, Janna M. +3 more
openaire +2 more sources