Results 31 to 40 of about 13,358 (220)

Differentiating the Roles of UL16, UL21, and Us3 in the Nuclear Egress of Herpes Simplex Virus Capsids [PDF]

Journal of Virology, 2020
Bruce W Banfield, Renee L Finnen
exaly   +2 more sources

Molecular plasticity of herpesvirus nuclear egress analysed in situ. [PDF]

Nat Microbiol
The viral nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without compromising the nuclear envelope integrity. The NEC lattice assembles on the inner nuclear membrane and mediates the budding of nascent nucleocapsids into the perinuclear space and their subsequent release into the cytosol.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp BG, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +4 more sources

The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. [PDF]

PLoS Pathogens, 2015
Progeny capsids of herpesviruses leave the nucleus by budding through the nuclear envelope. Two viral proteins, the membrane protein pUL34 and the nucleo-phosphoprotein pUL31 form the nuclear egress complex that is required for capsid egress out of the ...
Christina Funk, Melanie Ott, Verena Raschbichler, Claus-Henning Nagel, Anne Binz, Beate Sodeik, Rudolf Bauerfeind, Susanne M Bailer   +7 more
doaj   +1 more source

The nuclear egress complex of MHV-68 is not essential for nuclear egress but mediates C-capsid specificity

Abstract Herpesvirus capsids must exit the nucleus to undergo additional maturation steps in the cytoplasm, such as secondary envelopment. This process is orchestrated by the nuclear egress complex (NEC), a conserved heterodimer that deforms the inner nuclear membrane and facilitates capsid egress.
Sanders S, Schneider C, Soh TK, Kotova E, Steer B, Reimer R, Ruzsics Z, Adler H, Bosse JB.   +8 more
europepmc   +2 more sources

Nuclear envelope budding and its cellular functions

Nucleus, 2023
The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Katharina S. Keuenhof, Verena Kohler, Filomena Broeskamp, Dimitra Panagaki, Sean D. Speese, Sabrina Büttner, Johanna L. Höög   +6 more
doaj   +1 more source

Nuclear Egress

, 2020
During viral replication, herpesviruses utilize a unique strategy, termed nuclear egress, to translocate capsids from the nucleus into the cytoplasm. This initial budding step transfers a newly formed capsid from within the nucleus, too large to fit through nuclear pores, through the inner nuclear membrane to the perinuclear space.
Elizabeth B, Draganova, Michael K, Thorsen, Ekaterina E, Heldwein   +2 more
openaire   +2 more sources

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress [PDF]

Current Opinion in Cell Biology, 2017
Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding ...
Ming F, Lye, Adrian R, Wilkie, David J, Filman, James M, Hogle, Donald M, Coen   +4 more
openaire   +2 more sources

Venture from the Interior—Herpesvirus pUL31 Escorts Capsids from Nucleoplasmic Replication Compartments to Sites of Primary Envelopment at the Inner Nuclear Membrane

Cells, 2017
Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress.
Susanne M. Bailer
doaj   +1 more source

Vesicular Nucleo-Cytoplasmic Transport—Herpesviruses as Pioneers in Cell Biology

Viruses, 2016
Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm.
Thomas C. Mettenleiter
doaj   +1 more source

Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions

Viruses, 2021
The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked ...
Veronica Sanchez, William Britt
doaj   +1 more source