Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering [PDF]
mBio, 2021 During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is mediated by the viral nuclear egress complex (NEC) that deforms the membrane around the capsid by ...
Michael K. Thorsen +6 more
doaj +2 more sources
The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice. [PDF]
PLoS PathogensNuclear egress is an essential process in herpesvirus replication whereby nascent capsids translocate from the nucleus to the cytoplasm. This initial step of nuclear egress-budding at the inner nuclear membrane-is coordinated by the nuclear egress ...
Elizabeth B Draganova +8 more
doaj +2 more sources
The HSV1 Tail-Anchored Membrane Protein pUL34 Contains a Basic Motif That Supports Active Transport to the Inner Nuclear Membrane Prior to Formation of the Nuclear Egress Complex [PDF]
Viruses, 2021 Herpes simplex virus type 1 nucleocapsids are released from the host nucleus by a budding process through the nuclear envelope called nuclear egress. Two viral proteins, the integral membrane proteins pUL34 and pUL31, form the nuclear egress complex at ...
Christina Funk +4 more
doaj +2 more sources
The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress
mBio, 2017 Many viruses migrate between different cellular compartments for successive stages of assembly. The HSV-1 capsid assembles in the nucleus and then transfers into the cytoplasm.
William W. Newcomb +5 more
doaj +3 more sources
Expression, Purification and Crystallization of the Herpesvirus Nuclear Egress Complex (NEC) [PDF]
Bio-Protocol, 2016 The protocol describes the production and crystallization of the soluble form of the nuclear egress complex (NEC) from Herpes simplex virus 1 and Pseudorabies virus. The NEC is a heterodimer that consists of conserved proteins UL31 and UL34.
Janna Bigalke, Ekaterina Heldwein
doaj +3 more sources
Confined no more: Viral mechanisms of nuclear entry and egress
The International Journal of Biochemistry & Cell Biology, 2020 Viruses are obligatory intracellular parasites. For their efficient replication, many require access to the nuclear interior. Yet, only few viral particles are small enough to passively diffuse through the nuclear pore complexes, calling for alternative strategies to bypass the nuclear envelope barrier.
Freya Molenberghs +2 more
openaire +4 more sources
Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. [PDF]
PLoS Pathogens, 2009 The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress).
Sofia Hamirally +12 more
doaj +2 more sources
Virus-host interactions during nuclear egress of parvoviruses
, 2022 unknown ...
Mattola, Salla
openaire +4 more sources
Differentiating the Roles of UL16, UL21, and Us3 in the Nuclear Egress of Herpes Simplex Virus Capsids [PDF]
Journal of Virology, 2020 Bruce W Banfield, Renee L Finnen
exaly +2 more sources
Metformin inhibits nuclear egress of chromatin fragments in senescence and aging. [PDF]
Nat AgingChronic inflammation promotes aging and age-associated diseases. While metabolic interventions can modulate inflammation, how metabolism and inflammation are connected remains unclear. Cytoplasmic chromatin fragments (CCFs) drive chronic inflammation through the cGAS-STING pathway in senescence and aging.
Kumazawa T +13 more
europepmc +3 more sources