Results 21 to 30 of about 1,436,031 (236)

Autographa californica multiple nucleopolyhedrovirus Ac51 interacts with Ac66 and facilitates its nuclear localization to promote the nuclear egress of nucleocapsids [PDF]

Journal of Virology
Autographa californica multiple nucleopolyhedrovirus is a large DNA virus that replicates within host nuclei. The mechanism underlying the nuclear egress of viral nucleocapsids is not fully understood.
Jianxiang Qiu, Guo-Sheng Zhu, Jiaxin Liu, Longkuan Feng, Zefen Pang, Dandong Zhu, Kanghong Chen, Xiukui Yan, Ao Li, Chuming You, Zhixin Fang   +10 more
doaj   +2 more sources

The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. [PDF]

PLoS Pathogens, 2022
During replication, herpesviral capsids are translocated from the nucleus into the cytoplasm by an unusual mechanism, termed nuclear egress, that involves capsid budding at the inner nuclear membrane.
Michael K Thorsen, Elizabeth B Draganova, Ekaterina E Heldwein   +2 more
doaj   +2 more sources

GRWD1 enhances HSV-1 replication by facilitating nuclear egress [PDF]

Microbiology Spectrum
Herpes simplex virus 1 (HSV-1) depends on host factors for its replication. Here, we identify glutamate-rich WD40 repeat-containing 1 (GRWD1) as a novel pro-viral host factor that facilitates HSV-1 nuclear egress. GRWD1 knockdown trapped nucleocapsids in
Zimeng Kong, Chao Gao, Xingyun Liu, Teng Xue, Xinxin Liang, Peijie Yan, Rui Zhang, Jun Tang   +7 more
doaj   +2 more sources

Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation [PDF]

Viruses, 2021
Nuclear egress is a common herpesviral process regulating nucleocytoplasmic capsid release. For human cytomegalovirus (HCMV), the nuclear egress complex (NEC) is determined by the pUL50-pUL53 core that regulates multicomponent assembly with NEC ...
Sigrun Häge, Eric Sonntag, Adriana Svrlanska, Eva Maria Borst, Anne-Charlotte Stilp, Deborah Horsch, Regina Müller, Barbara Kropff, Jens Milbradt, Thomas Stamminger, Ursula Schlötzer-Schrehardt, Manfred Marschall   +11 more
doaj   +2 more sources

The Complex Regulatory Role of Cytomegalovirus Nuclear Egress Protein pUL50 in the Production of Infectious Virus [PDF]

Cells, 2021
The regulation of the nucleocytoplasmic release of herpesviral capsids is defined by the process of nuclear egress. Due to their large size, nuclear capsids are unable to traverse via nuclear pores, so that herpesviruses evolved to develop a vesicular ...
Sigrun Häge, Nicole Büscher, Victoria Pakulska, Friedrich Hahn, Annie Adrait, Steffi Krauter, Eva Maria Borst, Ursula Schlötzer-Schrehardt, Yohann Couté, Bodo Plachter, Manfred Marschall   +10 more
doaj   +2 more sources

NECing goes: flexibility of the herpesvirus nuclear egress complex [PDF]

, 2023
Abstract The nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which bud into the perinuclear space.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp B, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +3 more sources

Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery [PDF]

Viruses, 2022
After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress.
Adrian R. Wilkie, Mayuri Sharma, Margaret Coughlin, Jean M. Pesola, Maria Ericsson, Jessica L. Lawler, Rosio Fernandez, Donald M. Coen   +7 more
doaj   +2 more sources

Nuclear Egress of Herpesviruses

, 2016
Herpesvirus particles mature in two different cellular compartments. While capsid assembly and packaging of the genomic linear double-stranded DNA occur in the nucleus, virion formation takes place in the cytoplasm by the addition of numerous tegument ...
Teresa Hellberg, Lars Paßvogel, Katharina S. Schulz, Barbara G. Klupp, Thomas C. Mettenleiter   +4 more
openaire   +2 more sources

When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

Viruses, 2021
The proper assembly and dissemination of progeny virions is a fundamental step in virus replication. As a whole, viruses have evolved a myriad of strategies to exploit cellular compartments and mechanisms to ensure a successful round of infection.
Kevin M. Rose, Stephanie J. Spada, Vanessa M. Hirsch, Fadila Bouamr   +3 more
doaj   +3 more sources

Nuclear Envelope Breakdown Can Substitute for Primary Envelopment-Mediated Nuclear Egress of Herpesviruses [PDF]

Journal of Virology, 2011
ABSTRACT Herpesvirus nucleocapsids assemble in the nucleus but mature to infectious virions in the cytoplasm. To gain access to this cellular compartment, nucleocapsids are translocated to the cytoplasm by primary envelopment at the inner nuclear membrane and subsequent fusion of the primary envelope with the outer nuclear membrane.
Barbara G, Klupp, Harald, Granzow, Thomas C, Mettenleiter   +2 more
openaire   +4 more sources