Function of Torsin AAA+ ATPases in Pseudorabies Virus Nuclear Egress [PDF]
Cells, 2020 Newly assembled herpesvirus nucleocapsids traverse the intact nuclear envelope by a vesicle-mediated nucleo-cytoplasmic transport for final virion maturation in the cytoplasm.
Julia E. Hölper +4 more
doaj +7 more sources
A Peptide Inhibitor of the Human Cytomegalovirus Core Nuclear Egress Complex [PDF]
Pharmaceuticals, 2022 The replication of human cytomegalovirus (HCMV) involves a process termed nuclear egress, which enables translocation of newly formed viral capsids from the nucleus into the cytoplasm.
Sewar Alkhashrom +7 more
doaj +4 more sources
Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties [PDF]
Viruses, 2020 Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellular ...
Manfred Marschall +12 more
doaj +4 more sources
Autographa californica multiple nucleopolyhedrovirus Ac51 interacts with Ac66 and facilitates its nuclear localization to promote the nuclear egress of nucleocapsids [PDF]
Journal of VirologyAutographa californica multiple nucleopolyhedrovirus is a large DNA virus that replicates within host nuclei. The mechanism underlying the nuclear egress of viral nucleocapsids is not fully understood.
Jianxiang Qiu +10 more
doaj +2 more sources
Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress [PDF]
Proceedings, 2020 During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova +3 more
doaj +4 more sources
The Complex Regulatory Role of Cytomegalovirus Nuclear Egress Protein pUL50 in the Production of Infectious Virus [PDF]
Cells, 2021 The regulation of the nucleocytoplasmic release of herpesviral capsids is defined by the process of nuclear egress. Due to their large size, nuclear capsids are unable to traverse via nuclear pores, so that herpesviruses evolved to develop a vesicular ...
Sigrun Häge +10 more
doaj +2 more sources
Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation [PDF]
Viruses, 2021 Nuclear egress is a common herpesviral process regulating nucleocytoplasmic capsid release. For human cytomegalovirus (HCMV), the nuclear egress complex (NEC) is determined by the pUL50-pUL53 core that regulates multicomponent assembly with NEC ...
Sigrun Häge +11 more
doaj +2 more sources
The Knowns and Unknowns of Herpesvirus Nuclear Egress
Annual Review of Virology, 2023 Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus capsids into the cytosol. Budding of the (nucleo)capsid at and scission from the inner nuclear membrane (INM) is mediated by the viral nuclear egress complex (NEC) resulting
Barbara G, Klupp, Thomas C, Mettenleiter
openaire +4 more sources
A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress [PDF]
mBio, 2016 Herpesviruses, which include important pathogens, remodel the host cell nucleus to facilitate infection. This remodeling includes the formation of structures called replication compartments (RCs) in which herpesviruses replicate their DNA.
Adrian R. Wilkie +2 more
doaj +4 more sources
Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery [PDF]
Viruses, 2022 After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress.
Adrian R. Wilkie +7 more
doaj +2 more sources