Results 11 to 20 of about 1,500,246 (134)

The MHV-68 nuclear egress complex supports C-capsid selective capsid egress [PDF]

Journal of Virology
Herpesvirus capsids assemble within the host nucleus and must traverse the nuclear envelope to undergo final envelopment in the cytoplasm. This exit strategy is orchestrated by the nuclear egress complex (NEC), a conserved heterodimeric protein complex ...
Saskia Sanders, Carola Schneider, Timothy K. Soh, Elena Kotova, Dörte Stalling, Beatrix Steer, Rudolph Reimer, Zsolt Ruzsics, Heiko Adler, Jens B. Bosse   +9 more
doaj   +4 more sources

A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress [PDF]

mBio, 2016
Herpesviruses, which include important pathogens, remodel the host cell nucleus to facilitate infection. This remodeling includes the formation of structures called replication compartments (RCs) in which herpesviruses replicate their DNA.
Adrian R. Wilkie, Jessica L. Lawler, Donald M. Coen   +2 more
doaj   +7 more sources

Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress [PDF]

Proceedings, 2020
During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova, Jiayan Zhang, Hong Zhou, Ekaterina Heldwein   +3 more
doaj   +7 more sources

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97 [PDF]

Viruses, 2018
The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress.
Jens Milbradt, Eric Sonntag, Sabrina Wagner, Hanife Strojan, Christina Wangen, Tihana Lenac Rovis, Berislav Lisnic, Stipan Jonjic, Heinrich Sticht, William J. Britt, Ursula Schlötzer-Schrehardt, Manfred Marschall   +11 more
doaj   +4 more sources

Nuclear Egress. [PDF]

Curr Issues Mol Biol, 2021
During viral replication, herpesviruses utilize a unique strategy, termed nuclear egress, to translocate capsids from the nucleus into the cytoplasm. This initial budding step transfers a newly formed capsid from within the nucleus, too large to fit through nuclear pores, through the inner nuclear membrane to the perinuclear space.
Draganova EB, Thorsen MK, Heldwein EE.
europepmc   +5 more sources

HSV-1 exploits host heterochromatin for nuclear egress. [PDF]

J Cell Biol, 2023
Herpes simplex virus (HSV-1) progeny form in the nucleus and exit to successfully infect other cells. Newly formed capsids navigate complex chromatin architecture to reach the inner nuclear membrane (INM) and egress. Here, we demonstrate by transmission electron microscopy (TEM) that HSV-1 capsids traverse heterochromatin associated with trimethylation
Lewis HC, Kelnhofer-Millevolte LE, Brinkley MR, Arbach HE, Arnold EA, Sanders S, Bosse JB, Ramachandran S, Avgousti DC.   +8 more
europepmc   +6 more sources

The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice. [PDF]

PLoS Pathogens
Nuclear egress is an essential process in herpesvirus replication whereby nascent capsids translocate from the nucleus to the cytoplasm. This initial step of nuclear egress-budding at the inner nuclear membrane-is coordinated by the nuclear egress ...
Elizabeth B Draganova, Hui Wang, Melanie Wu, Shiqing Liao, Amber Vu, Gonzalo L Gonzalez-Del Pino, Z Hong Zhou, Richard J Roller, Ekaterina E Heldwein   +8 more
doaj   +3 more sources

Molecular plasticity of herpesvirus nuclear egress analysed in situ. [PDF]

Nat Microbiol
The viral nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without compromising the nuclear envelope integrity. The NEC lattice assembles on the inner nuclear membrane and mediates the budding of nascent nucleocapsids into the perinuclear space and their subsequent release into the cytosol.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp BG, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +5 more sources

The Knowns and Unknowns of Herpesvirus Nuclear Egress [PDF]

Annual Review of Virology, 2023
Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus capsids into the cytosol. Budding of the (nucleo)capsid at and scission from the inner nuclear membrane (INM) is mediated by the viral nuclear egress complex (NEC) resulting
Barbara G, Klupp, Thomas C, Mettenleiter
openaire   +3 more sources

Viruses and Nuclear Egress [PDF]

, 2022
This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm.
core   +3 more sources