Results 11 to 20 of about 1,436,031 (236)

The MHV-68 nuclear egress complex supports C-capsid selective capsid egress [PDF]

Journal of Virology
Herpesvirus capsids assemble within the host nucleus and must traverse the nuclear envelope to undergo final envelopment in the cytoplasm. This exit strategy is orchestrated by the nuclear egress complex (NEC), a conserved heterodimeric protein complex ...
Saskia Sanders, Carola Schneider, Timothy K. Soh, Elena Kotova, Dörte Stalling, Beatrix Steer, Rudolph Reimer, Zsolt Ruzsics, Heiko Adler, Jens B. Bosse   +9 more
doaj   +4 more sources

A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress [PDF]

mBio, 2016
Herpesviruses, which include important pathogens, remodel the host cell nucleus to facilitate infection. This remodeling includes the formation of structures called replication compartments (RCs) in which herpesviruses replicate their DNA.
Adrian R. Wilkie, Jessica L. Lawler, Donald M. Coen   +2 more
doaj   +7 more sources

Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress [PDF]

Proceedings, 2020
During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova, Jiayan Zhang, Hong Zhou, Ekaterina Heldwein   +3 more
doaj   +7 more sources

Nuclear Egress. [PDF]

Curr Issues Mol Biol, 2021
During viral replication, herpesviruses utilize a unique strategy, termed nuclear egress, to translocate capsids from the nucleus into the cytoplasm. This initial budding step transfers a newly formed capsid from within the nucleus, too large to fit through nuclear pores, through the inner nuclear membrane to the perinuclear space.
Draganova EB, Thorsen MK, Heldwein EE.
europepmc   +5 more sources

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97 [PDF]

Viruses, 2018
The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress.
Jens Milbradt, Eric Sonntag, Sabrina Wagner, Hanife Strojan, Christina Wangen, Tihana Lenac Rovis, Berislav Lisnic, Stipan Jonjic, Heinrich Sticht, William J. Britt, Ursula Schlötzer-Schrehardt, Manfred Marschall   +11 more
doaj   +4 more sources

HSV-1 exploits host heterochromatin for nuclear egress. [PDF]

J Cell Biol, 2023
Herpes simplex virus (HSV-1) progeny form in the nucleus and exit to successfully infect other cells. Newly formed capsids navigate complex chromatin architecture to reach the inner nuclear membrane (INM) and egress. Here, we demonstrate by transmission electron microscopy (TEM) that HSV-1 capsids traverse heterochromatin associated with trimethylation
Lewis HC, Kelnhofer-Millevolte LE, Brinkley MR, Arbach HE, Arnold EA, Sanders S, Bosse JB, Ramachandran S, Avgousti DC.   +8 more
europepmc   +6 more sources

Molecular plasticity of herpesvirus nuclear egress analysed in situ. [PDF]

Nat Microbiol
The viral nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without compromising the nuclear envelope integrity. The NEC lattice assembles on the inner nuclear membrane and mediates the budding of nascent nucleocapsids into the perinuclear space and their subsequent release into the cytosol.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp BG, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +5 more sources

Viruses and Nuclear Egress [PDF]

, 2022
This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm.
core   +3 more sources

Nuclear entry and egress of parvoviruses

Molecular Microbiology, 2022
AbstractParvoviruses are small non‐enveloped single‐stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase A2 domain on the capsid surface, and escape into the cytosol, parvovirus capsids enter the nucleus.
Mattola, Salla, Aho, Vesa, Bustamante‐Jaramillo, Luisa F., Pizzioli, Edoardo, Kann, Michael, Vihinen‐Ranta, Maija   +5 more
core   +7 more sources

‘Come together’—The Regulatory Interaction of Herpesviral Nuclear Egress Proteins Comprises Both Essential and Accessory Functions [PDF]

Cells, 2022
Herpesviral nuclear egress is a fine-tuned regulatory process that defines the nucleocytoplasmic release of viral capsids. Nuclear capsids are unable to traverse via nuclear pores due to the fact of their large size; therefore, herpesviruses evolved to ...
Sigrun Häge, Manfred Marschall
doaj   +2 more sources