Results 101 to 110 of about 26,575 (247)

Regulation of 92-kD gelatinase release in HL-60 leukemia cells [PDF]

, 1994
Matrix metalloproteinase 9 (MMP-9), also known as 92-kD type IV collagenase/gelatinase, is believed to play a critical role in tumor invasion and metastasis. Here, we report that MMP-9 was constitutively released from the human promyelocytic cell line HL-
Kolb, H., Petrides, P. E., Ries, Christian   +2 more
core  

HVint: a strategy for identifying novel protein-protein interactions in Herpes Simplex Virus Type 1 [PDF]

, 2016
Human herpesviruses are widespread human pathogens with a remarkable impact on worldwide public health. Despite intense decades of research, the molecular details in many aspects of their function remain to be fully characterized.
Albright, Antinone, Aranda, Bastian, Berman, Blohm, Booy, Brady, Brückner, Budayeva, Calderone, Calderwood, Cardone, Chabaud, Chabaud, Chatr-Aryamontri, Chen, Chen, Chentoufi, Chowdary, Coller, Conner, Connolly, Cristea, Dai, Dai, Daikoku, de Chassey, de Oliveira, DeBlasio, Deng, Desai, Desai, Desai, Deutsch, Douglas, Dufour, Durmuş Tekir, Döhner, Eisenberg, Engel, Folador, Fossum, Funk, Greco, Grünenfelder, Grünewald, Guirimand, Guo, Hagen, Hosur, Hosur, Jaeger, Kerrien, Klupp, Kobayashi, Kopp, Kopp, Kramer, Krautwald, Kshirsagar, Kulak, Langelier, Lawson, Lee, Leege, Lenk, Lin, Loomis, Loret, Lyman, López-Blanco, Lövheim, Marcoux, Marras, McDowall, Meckes, Mora, Murakami, Nagel, Nagel, Navlakha, Nourani, Nozawa, Orchard, Panagiotidis, Radtke, Ramisetty, Remmert, Reynolds, Rollenhagen, Roller, Roller, Rowles, Rozen, Saeed, Schnee, Sheaffer, Silva, Singh, Snijder, Snyder, Sprinzak, Stampfer, Stellberger, Stelzl, Sugimoto, Suzek, Szklarczyk, Taylor, The UniProt Consortium, Thomsen, To, Tomishima, Toropova, Trus, Trus, Uetz, Uetz, Villaveces, Vittone, Vizcaíno, Wills, Winterbach, Wnuk, Xenarios, Yang, Yeh, You, Yu, Zahiri, Zeev-Ben-Mordehai, Zhang, Zhou   +133 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication

Cells, 2019
The primary envelopment/de-envelopment of Herpes viruses during nuclear exit is poorly understood. In Herpes simplex virus type-1 (HSV-1), proteins pUL31 and pUL34 are critical, while pUS3 and some others contribute; however, efficient membrane fusion ...
Natalia Saiz-Ros, Rafal Czapiewski, Ilaria Epifano, Andrew Stevenson, Selene K. Swanson, Charles R. Dixon, Dario B. Zamora, Marion McElwee, Swetha Vijayakrishnan, Christine A. Richardson, Li Dong, David A. Kelly, Lior Pytowski, Martin W. Goldberg, Laurence Florens, Sheila V. Graham, Eric C. Schirmer   +16 more
doaj   +1 more source

The \^G Search for Extraterrestrial Civilizations with Large Energy Supplies. IV. The Signatures and Information Content of Transiting Megastructures

, 2015
Arnold (2005), Forgan (2013), and Korpela et al. (2015) noted that planet-sized artificial structures could be discovered with Kepler as they transit their host star.
Cartier, Kimberly M. S., Ford, Eric B., Jontof-Hutter, Daniel, Wright, Jason T., Zhao, Ming   +4 more
core   +1 more source

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells [PDF]

, 2016
Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport ...
Castro, Guillermo Raul, Grumelli, Sandra, Islan, German Abel   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Eclipse Timings of the Transient Low Mass X-ray Binary EXO0748-676. IV. The Rossi X-Ray Timing Explorer Eclipses

, 2009
We report our complete database of X-ray eclipse timings of the low mass X-ray binary EXO0748-676 observed by the Rossi X-Ray Timing Explorer (RXTE) satellite.
Bevington, Hall, Hertz, Jahoda, Jahoda, Kent S. Wood, Koen, Lanza, Lewin, Maeda, Michael T. Wolff, Paul L. Hertz, Paul S. Ray, Porquet, Rots, Sakano, Simon, Soderhjelm, Wachter, Wolff, Wolff   +20 more
core   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Carbajo-Lozoya, Javier, Dall'Armi, Ekatarina von, Ditt, Vanessa, Drosten, Christian, Friedel, Caroline C., Haas, Juergen G., Herrler, Georg, Herzog, Petra, Hilgenfeld, Rolf, Kallies, Stefan, Kuri, Thomas, Kögl, Manfred, Müller, Marcel A., Niemeyer, Daniela, Pfefferle, Susanne, Pumpor, Ksenia, Pöhlmann, Stefan, Schwarz, Frank, Schwegmann-Wessels, Christel, Schöpf, Julia, Steffen, Imke, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Thiel, Volker, Weber, Friedemann, Zimmer, Ralf, Züst, Roland   +27 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source