Results 21 to 30 of about 6,512,295 (115)

Host and Viral Factors Involved in Nuclear Egress of Herpes Simplex Virus 1 [PDF]

Viruses, 2021
Herpes simplex virus 1 (HSV-1) replicates its genome and packages it into capsids within the nucleus. HSV-1 has evolved a complex mechanism of nuclear egress whereby nascent capsids bud on the inner nuclear membrane to form perinuclear virions that ...
Jun Arii
doaj   +2 more sources

‘Getting Better’—Is It a Feasible Strategy of Broad Pan-Antiherpesviral Drug Targeting by Using the Nuclear Egress-Directed Mechanism? [PDF]

International Journal of Molecular Sciences
The herpesviral nuclear egress represents an essential step of viral replication efficiency in host cells, as it defines the nucleocytoplasmic release of viral capsids.
Manfred Marschall, Jintawee Kicuntod, Julia Tillmanns   +2 more
exaly   +3 more sources

The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress [PDF]

mBio, 2017
Many viruses migrate between different cellular compartments for successive stages of assembly. The HSV-1 capsid assembles in the nucleus and then transfers into the cytoplasm.
William W. Newcomb, Juan Fontana, Dennis C. Winkler, Naiqian Cheng, J. Bernard Heymann, Alasdair C. Steven   +5 more
doaj   +2 more sources

Identification and subcellular localization of proteins that interact with Duck plague virus pUL14 in infected host cells [PDF]

Poultry Science
Duck plague (DP), which is caused by duck plague virus (DPV), is an infectious disease that severely harms the waterfowl breeding industry. The UL14 protein (pUL14) is a tegument protein encoded by the UL14 gene, which is located in the unique long (UL ...
Jieyu Wan, Mingshu Wang, Anchun Cheng, Wei Zhang, Qiao Yang, Bin Tian, Xumin Ou, Di Sun, Yu He, Xinxin Zhao, Ying Wu, Shaqiu Zhang, Juan Huang, Zhen Wu, YanLing Yu, Ling Zhang, Dekang Zhu, Renyong Jia, Mafeng Liu, Shun Chen   +19 more
doaj   +2 more sources

NECing goes: flexibility of the herpesvirus nuclear egress complex [PDF]

, 2023
The nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which bud into the ...
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp B, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +2 more sources

Molecular plasticity of herpesvirus nuclear egress analysed in situ. [PDF]

Nat Microbiol
The viral nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without compromising the nuclear envelope integrity. The NEC lattice assembles on the inner nuclear membrane and mediates the budding of nascent nucleocapsids ...
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp BG, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +2 more sources

Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation

Viruses, 2021
Nuclear egress is a common herpesviral process regulating nucleocytoplasmic capsid release. For human cytomegalovirus (HCMV), the nuclear egress complex (NEC) is determined by the pUL50-pUL53 core that regulates multicomponent assembly with NEC ...
Sigrun Häge, Eric Sonntag, Adriana Svrlanska, Eva Maria Borst, Anne-Charlotte Stilp, Deborah Horsch, Regina Müller, Barbara Kropff, Jens Milbradt, Thomas Stamminger, Ursula Schlötzer-Schrehardt, Manfred Marschall   +11 more
doaj   +1 more source

The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism.

PLoS Pathogens, 2022
During replication, herpesviral capsids are translocated from the nucleus into the cytoplasm by an unusual mechanism, termed nuclear egress, that involves capsid budding at the inner nuclear membrane.
Michael K Thorsen, Elizabeth B Draganova, Ekaterina E Heldwein   +2 more
doaj   +1 more source

Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering

mBio, 2021
During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is mediated by the viral nuclear egress complex (NEC) that deforms the membrane around the capsid by ...
Michael K. Thorsen, Alex Lai, Michelle W. Lee, David P. Hoogerheide, Gerard C. L. Wong, Jack H. Freed, Ekaterina E. Heldwein   +6 more
doaj   +1 more source

Role of Vesicle-Associated Membrane Protein-Associated Proteins (VAP) A and VAPB in Nuclear Egress of the Alphaherpesvirus Pseudorabies Virus

Viruses, 2021
The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood.
Anna D. Dorsch, Julia E. Hölper, Kati Franzke, Luca M. Zaeck, Thomas C. Mettenleiter, Barbara G. Klupp   +5 more
doaj   +1 more source