Results 31 to 40 of about 1,816 (135)

The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors

Viruses, 2022
The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL50–pUL53 ...
Jintawee Kicuntod, Sigrun Häge, Friedrich Hahn, Heinrich Sticht, Manfred Marschall   +4 more
doaj   +1 more source

HVint: a strategy for identifying novel protein-protein interactions in Herpes Simplex Virus Type 1 [PDF]

, 2016
Human herpesviruses are widespread human pathogens with a remarkable impact on worldwide public health. Despite intense decades of research, the molecular details in many aspects of their function remain to be fully characterized.
Albright, Antinone, Aranda, Bastian, Berman, Blohm, Booy, Brady, Brückner, Budayeva, Calderone, Calderwood, Cardone, Chabaud, Chabaud, Chatr-Aryamontri, Chen, Chen, Chentoufi, Chowdary, Coller, Conner, Connolly, Cristea, Dai, Dai, Daikoku, de Chassey, de Oliveira, DeBlasio, Deng, Desai, Desai, Desai, Deutsch, Douglas, Dufour, Durmuş Tekir, Döhner, Eisenberg, Engel, Folador, Fossum, Funk, Greco, Grünenfelder, Grünewald, Guirimand, Guo, Hagen, Hosur, Hosur, Jaeger, Kerrien, Klupp, Kobayashi, Kopp, Kopp, Kramer, Krautwald, Kshirsagar, Kulak, Langelier, Lawson, Lee, Leege, Lenk, Lin, Loomis, Loret, Lyman, López-Blanco, Lövheim, Marcoux, Marras, McDowall, Meckes, Mora, Murakami, Nagel, Nagel, Navlakha, Nourani, Nozawa, Orchard, Panagiotidis, Radtke, Ramisetty, Remmert, Reynolds, Rollenhagen, Roller, Roller, Rowles, Rozen, Saeed, Schnee, Sheaffer, Silva, Singh, Snijder, Snyder, Sprinzak, Stampfer, Stellberger, Stelzl, Sugimoto, Suzek, Szklarczyk, Taylor, The UniProt Consortium, Thomsen, To, Tomishima, Toropova, Trus, Trus, Uetz, Uetz, Villaveces, Vittone, Vizcaíno, Wills, Winterbach, Wnuk, Xenarios, Yang, Yeh, You, Yu, Zahiri, Zeev-Ben-Mordehai, Zhang, Zhou   +133 more
core   +1 more source

Viruses and Nuclear Egress [PDF]

, 2022
This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm.

core   +1 more source

The HSV1 Tail-Anchored Membrane Protein pUL34 Contains a Basic Motif That Supports Active Transport to the Inner Nuclear Membrane Prior to Formation of the Nuclear Egress Complex

Viruses, 2021
Herpes simplex virus type 1 nucleocapsids are released from the host nucleus by a budding process through the nuclear envelope called nuclear egress. Two viral proteins, the integral membrane proteins pUL34 and pUL31, form the nuclear egress complex at ...
Christina Funk, Débora Marques da Silveira e Santos, Melanie Ott, Verena Raschbichler, Susanne M. Bailer   +4 more
doaj   +1 more source

Viral Takeover of the Host Ubiquitin System [PDF]

, 2011
Like the other more well-characterized post-translational modifications (phosphorylation, methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) protein to substrates has been shown to govern countless cellular ...
Jean K. Gustin, Ashlee V. Moses, Klaus Früh, Janet L. Douglas   +3 more
core   +1 more source

Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex

Scientific Reports, 2021
Herpesviruses infect a majority of the human population, establishing lifelong latent infections for which there is no cure. Periodic viral reactivation spreads infection to new hosts while causing various disease states particularly detrimental in the ...
Elizabeth B. Draganova, Ekaterina E. Heldwein   +1 more
doaj   +1 more source

Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release

Microbiology Spectrum, 2023
Epstein-Barr virus (EBV) replicates its genome in the nucleus and undergoes tegumentation and envelopment in the cytoplasm. We are interested in how the single-stranded DNA binding protein BALF2, which executes its function and distributes predominantly ...
Tsung-Yu Chao, Yi-Ying Cheng, Zi-Yun Wang, Tien-Fang Fang, Yu-Ruei Chang, Chi-Shane Fuh, Mei-Tzu Su, Yuan-Wei Su, Pang-Hung Hsu, Yu-Chen Su, Yu-Ching Chang, Ting-Yau Lee, Wei-Han Chou, Jaap M. Middeldorp, Jaakko Saraste, Mei-Ru Chen   +15 more
doaj   +1 more source

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Ferrari, G., Knight, A. M., Watts, C., Pieters, J.   +3 more
core   +1 more source

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Cell Reports, 2015
Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway.
Tzviya Zeev-Ben-Mordehai, Marion Weberruß, Michael Lorenz, Juliana Cheleski, Teresa Hellberg, Cathy Whittle, Kamel El Omari, Daven Vasishtan, Kyle C. Dent, Karl Harlos, Kati Franzke, Christoph Hagen, Barbara G. Klupp, Wolfram Antonin, Thomas C. Mettenleiter, Kay Grünewald   +15 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source