Results 61 to 70 of about 6,512,295 (115)

UTMD Suppresses CSF‐1 to Drive Macrophage‐Mediated Ferroptosis in Papillary Thyroid Carcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT The tumor microenvironment (TME) of Papillary Thyroid Carcinoma (PTC), particularly the role of tumor‐associated macrophages (TAMs), contributes to therapeutic resistance. This study investigated whether ultrasound‐targeted microbubble destruction (UTMD), a non‐invasive physical modality, could reprogram the TME through modulation of TAMs and ...
Yanqiang Niu, Zhenqiang Yao, Minghua Zhang, Jiayan Zhang, Yushan Li, Jinhui Xie, Zubang Zhou   +6 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Identification of Conserved Amino Acids in pUL34 Which Are Critical for Function of the Pseudorabies Virus Nuclear Egress Complex

, 2014
Nuclear egress of herpesvirus capsids is mediated by a conserved heterodimeric complex of two viral proteins, designated pUL34 and pUL31 in herpes simplex virus and pseudorabies virus (PrV).
Klupp, Barbara, Mettenleiter, Thomas C., Janke, Una, Passvogel, Lars, Granzow, Harald   +4 more
core   +1 more source

Generation and characterization of monoclonal antibodies specific for the Pseudorabies Virus nuclear egress complex

, 2020
During herpesvirus replication, newly synthesized nucleocapsids exit the nucleus by a vesicle-mediated transport, which requires the nuclear egress complex (NEC), composed of the conserved viral proteins designated as pUL31 and pUL34 in the ...
Klupp, Barbara, Mettenleiter, Thomas C., Franzke, Kati, Reiche, Sven, Hölper, Julia E.   +4 more
core   +1 more source

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Schirmer, Eric C, Eric C. Schirmer, Ohba, Tomoyuki, Tomoyuki Ohba, Takeharu Nishimoto, Larry Gerace   +7 more
core   +1 more source

INVESTIGATING THE ROLES OF HERPES SIMPLEX VIRUS TYPE 2 PROTEINS UL21 AND US3 IN REGULATION OF THE NUCLEAR EGRESS COMPLEX [PDF]

, 2021
Herpes Simplex Virus 2 (HSV-2) nuclear egress is mediated by viral nuclear egress complex (NEC) proteins, pUL31 and pUL34, found at the inner nuclear membrane of infected cells (INM).
Muradov, Jamil
core  

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication

, 2019
Herpesviruses require a nuclear egress complex (NEC) for efficient transit of nucleocapsids from the nucleus to the cytoplasm. The NEC orchestrates multiple steps during herpesvirus nuclear egress, including disruption of nuclear lamina and particle ...
Mansueto, My Sam, Coen, Donald, Arthanari, Haribabu, Wagner, Gerhard, Filman, David, Leigh, Kendra, Sharma, Mayuri, Hogle, James, Boeszoermenyi, Andras   +8 more
core   +1 more source

Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus

, 2014
International audienceHerpesviral capsids are assembled in the host cell nucleusbefore being translocated into the cytoplasm for further maturation. The crossing of the nuclear envelope represents a major event that requires the formation of the nuclear ...
Hamilton, Stuart, Schmeiser, Cathrin, Kraut, Alexandra, Wagner, Sabrina, Couté, Yohann, Milbradt, Jens, Ferro, Myriam, Pinkert, Sandra, Sticht, Heinrich, Lenac, Tihana, Marschall, Manfred, Sonntag, Eric, Claus, Claudia, Rawlinson, William, Hutterer, Corina   +14 more
core   +1 more source

Patterns of autologous and nonautologous interactions between core nuclear egress complex (NEC) proteins of α-, β- and γ-herpesviruses

[[abstract]]Nuclear egress is a regulated process shared by α-, β- and γ-herpesviruses. The core nuclear egress complex (NEC) is composed of the membrane-anchored protein homologs of human cytomegalovirus (HCMV) pUL50, murine cytomegalovirus (MCMV) pM50,
Bäuerle, Tobias, Bailer, Susanne M, Wangen, Christina, Milbradt, Jens, Lee, Chung-Pei, Tannig, Pierre, Müller, Regina, Seyler, Lisa, Häge, Sigrun, Marschall, Manfred, Borst, Eva Maria, Sonntag, Eric   +11 more
core  

Erratum to Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components

Journal of General Virology, 2016
Eric, Sonntag, Stuart T, Hamilton, Hanife, Bahsi, Sabrina, Wagner, Stipan, Jonjic, William D, Rawlinson, Manfred, Marschall, Jens, Milbradt   +7 more
openaire   +2 more sources