Results 61 to 70 of about 1,816 (135)

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Molecular Studies on Plasmodium During Development in the Mosquito

, 2011
Among the factors that regulate transmission of malaria are host-derived immune factors which can inhibit the progression of Plasmodium through the mosquito. This thesis addresses whether members of a family of LCCL/lectin Adhesive–like Proteins (LAPs)
Armson, Rebecca, Armson, Rebecca
core   +1 more source

Hitchhiker's Guide to the Swampland: The Cosmologist's Handbook to the String‐Theoretical Swampland Programme

Fortschritte der Physik, Volume 74, Issue 4, April 2026.
Abstract String theory has strong implications for cosmology, implying the absence of a cosmological constant, ruling out single‐field slow‐roll inflation, and that black holes decay. The origins of these statements are elucidated within the string‐theoretical swampland programme.
Kay Lehnert
wiley   +1 more source

Assessing the Effect of a Deep‐Rooted Grass on Belowground Carbon Storage in Cultivated Land: Insights From a Multi‐Site US Study

Earth's Future, Volume 14, Issue 4, April 2026.
Abstract Agriculture depletes soil organic carbon (SOC), partly due to the exclusion of deep‐rooted perennials. Reintroducing deep‐rooted perennials to cultivated land may help to mitigate SOC loss. We quantified the effect of deep roots on SOC by comparing 8 to 30 year‐old stands of switchgrass (Panicum virgatum L.) with paired annual row crop fields ...
Eric W. Slessarev, Jennifer Pett‐Ridge, Kyungjin Min, Asmeret Asefaw Berhe, Srabani Das, Randall D. Jackson, Julie D. Jastrow, Megan Kan, Sandeep Kumar, Todd Longbottom, Karis J. McFarlane, Erik Oerter, Brian K. Richards, G. Philip Robertson, Gregg R. Sanford, Erin E. Nuccio   +15 more
wiley   +1 more source

Enhancing Diagnostic Pathways for Bronchopulmonary Neuroendocrine Tumors: Assessment of the South Wales Neuroendocrine Tumor Service Transformation

Thoracic Cancer, Volume 17, Issue 8, April 2026.
Implementation of a dedicated neuroendocrine cancer service in South Wales significantly shortened diagnostic and treatment timelines for bronchopulmonary NETs, demonstrating the benefits of coordinated specialist input. ABSTRACT Background Bronchopulmonary neuroendocrine tumors (bpNETs) are uncommon lung neoplasms posing significant diagnostic and ...
Arouba Imtiaz, Oliver Burbidge, Mat Jones, Robin Ghosal, Janardhan Navaratnam, Craig Dyer, Helen E. Davies, Mohid S. Khan   +7 more
wiley   +1 more source

Endoscopic Ultrasound for the Management of Pancreatic Neuroendocrine Tumors: Diagnosis, Treatment, and Future Perspectives

Journal of Gastroenterology and Hepatology, Volume 41, Issue 4, Page 1173-1190, April 2026.
ABSTRACT Pancreatic neuroendocrine tumors (PanNETs) are increasingly diagnosed, reflecting greater clinical awareness, improved imaging, and revised classification. This review summarizes evidence on epidemiology, diagnostic workup, and endoscopic ultrasound (EUS)–guided management of PanNETs, encompassing diagnostic evaluation, tissue acquisition, and
Angelo Bruni, David Meacci, Roberto Falbo, Marco Fichera, Francesco Poggioli, Riccardo Casadei, Claudio Ricci, Leonardo Henry Eusebi   +7 more
wiley   +1 more source

European Society of Neuroendocrine Tumors (ENETS) 2025 guidance paper for lung and thymic carcinoids

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract This ENETS guidance paper, developed by a multidisciplinary working group, provides up‐to‐date and practical advice on the diagnosis and management of lung and thymic carcinoids, based on recent developments and study results. These recommendations aim to provide practical recommendations for the diagnosis, treatment and follow‐up of these ...
Eric Baudin, Alice Durand, Wieneke Buikhuisen, Jaume Capdevila, Martyn Caplin, Christophe M. Deroose, Clarisse Dromain, Antongiulio Faggiano, Pier Luigi Filosso, Gregory Kaltsas, Marco Volante, Thomas Walter, Rocio Garcia‐Carbonero   +12 more
wiley   +1 more source

Widespread hnRNP K Mislocalisation Suggests Differential Neuronal Vulnerability in the Neurodegenerative and Ageing Human Brain

Neuropathology and Applied Neurobiology, Volume 52, Issue 2, April 2026.
Widespread neuronal hnRNP K mislocalisation, characterised by nuclear loss and cytoplasmic aggregation, was identified across multiple brain regions in FTLD, PD and AD. Regional vulnerability patterns and correlations with motor symptoms suggest hnRNP K pathology as a common feature of neurodegeneration with potential functional and clinical ...
Xinwa Jiang, Christina E. Toomey, Tammaryn Lashley, Ariana Gatt   +3 more
wiley   +1 more source

Deep Underground Science and Engineering Laboratory - Preliminary Design Report

, 2011
The DUSEL Project has produced the Preliminary Design of the Deep Underground Science and Engineering Laboratory (DUSEL) at the rehabilitated former Homestake mine in South Dakota.
Acheson, Steven, Alonso, Jose, Bauer, Paul, Chan, Yuen-Dat, Chinowsky, William, Dangermond, Steve, De Vries, Syd, Detwiler, Jason A., DiGennaro, Richard, Exter, Elizabeth, Fernandez, Felix B., Freer, Elizabeth L., Gilchriese, Murdock G. D., Goldschmidt, Azriel, Grammann, Ben, Griffing, William, Harlan, Bill, Haxton, Wick C., Headley, Michael, Heise, Jaret, Hladysz, Zbigniew, Jacobs, Dianna, Johnson, Michael, Kadel, Richard, Kaufman, Robert, King, Greg, Lanou, Robert, Lemut, Alberto, Lesko, Kevin T., Ligeti, Zoltan, Marks, Steve, Martin, Ryan D., Matthesen, John, Matthew, Brendan, Matthews, Warren, McConnell, Randall, McElroy, William, Meyer, Deborah, Norris, Margaret, Plate, David, Robinson, Kem E., Roggenthen, William, Salve, Rohit, Sayler, Ben, Scheetz, John, Tarpinian, Jim, Taylor, David, Vardiman, David, Wheeler, Ron, Willhite, Joshua, Yeck, James   +50 more
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