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Mechanotransduction by nuclear envelope tension [PDF]

Nucleus
Mechanotransduction mediated by the tension in lipid membranes is a well-established paradigm. This has been studied largely in the context of the plasma membrane, but recent work shows that it applies also to endomembranes, and specifically to the ...
Sriivatsan G. Rajan, Pere Roca-Cusachs, Philipp Niethammer   +2 more
doaj   +2 more sources

Nuclear Envelope Dynamics in Dictyostelium Amoebae [PDF]

Cells
In the last decades, the study of many nuclear envelope components in Dictyostelium amoebae has revealed conserved mechanisms of nuclear envelope dynamics that root back unexpectedly deep into the eukaryotic tree of life.
Ralph Gräf, Petros Batsios, Marianne Grafe, Irene Meyer, Kristina Mitic   +4 more
doaj   +2 more sources

Nuclear envelope and chromatin choreography direct cellular differentiation [PDF]

Nucleus
The nuclear envelope plays an indispensable role in the spatiotemporal organization of chromatin and transcriptional regulation during the intricate process of cell differentiation.
Anjitha Nair, Jayati Khanna, Jashan Kler, Rohith Ragesh, Kundan Sengupta   +4 more
doaj   +2 more sources

Nuclear envelope signaling-role of phospholipid metabolism

European Journal of Histochemistry, 2009
Since the early 1980’s, there has been an explosion of research in an area often described as “signal transduction”. Loosely defined, signal transduction refers to the communication of a signal initiated by an extracellular agonist to the cell interior ...
DM Raben, JJ Baldassare
doaj   +3 more sources

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma [PDF]

Nucleus
The Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” Various factors that cooperate to repair the NE have been identified, including endosomal ...
Zuqian Wu, Issei Omura, Atsushi Saito, Kazunori Imaizumi, Yasunao Kamikawa   +4 more
doaj   +2 more sources

Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities

Cells, 2022
Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity.
Anne F. J. Janssen, Sophia Y. Breusegem, Delphine Larrieu   +2 more
doaj   +1 more source

Temporal Changes in Nuclear Envelope Permeability during Semi-Closed Mitosis in Dictyostelium Amoebae

Cells, 2023
The Amoebozoan Dictyostelium discoideum exhibits a semi-closed mitosis in which the nuclear membranes remain intact but become permeabilized to allow tubulin and spindle assembly factors to access the nuclear interior.
Kristina Mitic, Irene Meyer, Ralph Gräf, Marianne Grafe   +3 more
doaj   +1 more source

A dynamic barrier: remodeling of the nuclear envelope during closed mitosis in malaria parasites [PDF]

mSphere
Sabrina Absalon
openalex   +2 more sources

Automated analysis of cell migration and nuclear envelope rupture in confined environments. [PDF]

PLoS ONE, 2018
Recent in vitro and in vivo studies have highlighted the importance of the cell nucleus in governing migration through confined environments. Microfluidic devices that mimic the narrow interstitial spaces of tissues have emerged as important tools to ...
Joshua J Elacqua, Alexandra L McGregor, Jan Lammerding   +2 more
doaj   +1 more source

Cell migration in dense microenvironments

Comptes Rendus Biologies, 2023
The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating ...
de Freitas Nader, Guilherme Pedreira, García-Arcos, Juan Manuel   +1 more
doaj   +1 more source