Results 1 to 10 of about 2,002,555 (370)

Nuclear envelope and chromatin choreography direct cellular differentiation. [PDF]

Nucleus
The nuclear envelope plays an indispensable role in the spatiotemporal organization of chromatin and transcriptional regulation during the intricate process of cell differentiation.
Nair A, Khanna J, Kler J, Ragesh R, Sengupta K.   +4 more
europepmc   +2 more sources

Nuclear Envelope Dynamics in <i>Dictyostelium</i> Amoebae. [PDF]

Cells
In the last decades, the study of many nuclear envelope components in Dictyostelium amoebae has revealed conserved mechanisms of nuclear envelope dynamics that root back unexpectedly deep into the eukaryotic tree of life.
Gräf R, Batsios P, Grafe M, Meyer I, Mitic K.   +4 more
europepmc   +2 more sources

Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling

Cells, 2019
The primary functions of the nuclear envelope are to isolate the nucleoplasm and its contents from the cytoplasm as well as maintain the spatial and structural integrity of the nucleus.
Miki Hieda
doaj   +2 more sources

Nuclear envelope budding and its cellular functions. [PDF]

Nucleus, 2023
The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Keuenhof KS, Kohler V, Broeskamp F, Panagaki D, Speese SD, Büttner S, Höög JL.   +6 more
europepmc   +2 more sources

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

eLife, 2019
The integrity of the nuclear membranes coupled to the selective barrier of nuclear pore complexes (NPCs) are essential for the segregation of nucleoplasm and cytoplasm.
David J Thaller, Matteo Allegretti, Sapan Borah, Paolo Ronchi, Martin Beck, C Patrick Lusk   +5 more
doaj   +2 more sources

CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase [PDF]

Journal of Cell Science, 2015
In most organisms, telomeres attach to the nuclear envelope at the onset of meiosis to promote the crucial processes of pairing, recombination and synapsis during prophase I.
A. Viera, M. Alsheimer, R. Gómez, I. Berenguer, S. Ortega, Catherine E. Symonds, David Santamaría, R. Benavente, J. Suja   +8 more
semanticscholar   +3 more sources

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma. [PDF]

Nucleus
The Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” Various factors that cooperate to repair the NE have been identified, including endosomal ...
Wu Z, Omura I, Saito A, Imaizumi K, Kamikawa Y.   +4 more
europepmc   +2 more sources

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance The molecular mechanism for sealing newly formed nuclear envelopes was unclear until the recent discovery that endosomal sorting complexes required for transport III (ESCRT-III) proteins mediate this process.
Mingyu Gu, Dollie LaJoie, O. Chen, Alexander von Appen, M. Ladinsky, M. Redd, Linda S. Nikolova, P. Bjorkman, W. Sundquist, K. Ullman, A. Frost   +10 more
semanticscholar   +3 more sources

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases. [PDF]

Front Cell Dev Biol
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Wu T, Xu H, Cheng L, Wu R, Guo F, Chen X.   +5 more
europepmc   +2 more sources

Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities

Cells, 2022
Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity.
Anne F. J. Janssen, Sophia Y. Breusegem, Delphine Larrieu   +2 more
doaj   +1 more source