Results 31 to 40 of about 2,002,555 (370)
Cells, 2023 Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs.
Michael Schertzer +5 more
doaj +1 more source
TorsinA in the nuclear envelope [PDF]
Proceedings of the National Academy of Sciences, 2004 Early-onset torsion dystonia, a CNS-based movement disorder, is usually associated with a single amino acid deletion (ΔE302/303) in the protein torsinA. TorsinA is an AAA+ ATPase in the endoplasmic reticulum, but what it does is unknown. Here, we use torsinA mutants with defects in ATP hydrolysis (E171Q, ATP-bound) and ATP binding (K108A, ATP-free) to ...
Phyllis I. Hanson +3 more
openaire +3 more sources
Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]
, 2011 During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson +48 more
core +4 more sources
The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
core +1 more source
eLife, 2020 The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC.
Silvia Vergarajauregui +10 more
doaj +1 more source
Cell Communication and Signaling, 2023 Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs).
Paulina Gregorczyk +8 more
doaj +1 more source
The Dynamic Nature of the Nuclear Envelope [PDF]
Current Biology, 2018 Eukaryotes characteristically organize their genome in a separate compartment, the nucleus, which is surrounded by the nuclear envelope as a barrier. Ruptures of the nuclear envelope and exposure of chromatin threaten cell viability and cause genome instability.
P. Magistris, Wolfram Antonin
semanticscholar +4 more sources
Cold Spring Harbor Perspectives in Biology, 2010 The nuclear envelope (NE) is a highly regulated membrane barrier that separates the nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different proteins that have been implicated in chromatin organization and gene regulation.
openaire +3 more sources
The nuclear envelope at a glance [PDF]
Journal of Cell Science, 2010 The cell nucleus is the ‘mothership’ that organizes, protects and regulates the genome. The inner and outer nuclear membranes (INM and ONM, respectively) of the nuclear envelope (NE) have over 60 distinct membrane proteins, whose roles and functional sophistication might rival the cell surface.
Jason M. Berk, Katherine L. Wilson
openaire +3 more sources
The nuclear envelopathies and human diseases
Journal of Biomedical Science, 2009 The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope ...
Jeang Kuan-Teh, Chen Zi-Jie, Chi Ya-Hui
doaj +1 more source