Results 121 to 130 of about 73,362 (284)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus.

PLoS ONE
p62, an adapter protein involved in selective autophagy, is mainly found in the cytoplasm under normal conditions. Because p62 has nuclear localization signal (NLS) and a nuclear export signal, it has been suggested that p62 shuttles between the nucleus ...
Emi Kayama, Ning Baoshuo, Rinna Tatsuno, Kanako Nishi, Elsayed S I Mohammed, Yumi Abiko, Toru Yanagawa, Satoru Takahashi, Eiji Warabi   +8 more
doaj   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs [PDF]

, 1995
HIV-1 Rev protein directs nuclear export of pre-mRNAs and mRNAs containing its binding site, the Rev response element (RRE). To define how Rev acts, we used conjugates between bovine serum albumin (BSA) and peptides comprising the Rev activation domain ...
Mattajt, Lain W, Fischer, Utz, Boelens, Wilbert C, Huber, Jochen, Lührmann, Reinhard   +4 more
core   +1 more source

The Disruption of a Nuclear Export Signal in the C-Terminus of the Herpes Simplex Virus 1 Determinant of Pathogenicity UL24 Protein Leads to a Syncytial Plaque Phenotype. [PDF]

Viruses, 2023
Gonzalez CE, Ben Abdeljelil N, Pearson A.   +2 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy [PDF]

, 2016
YesTumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function.
Dakir, El-Habib, Mohamed El-Tanani, Morgan, Richard, El-Habib Dakir, Bethany Raynor, Raynor, Bethany, Richard Morgan, El-Tanani, Mohamed   +7 more
core   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

VDUP1 mediates nuclear export of HIF1α via CRM1-dependent pathway [PDF]

, 2007
Hypoxia-inducible factor 1α (HIF1α) is a critical transcriptional factor for inducing tumor metastasis, and stabilized under hypoxia but degraded by von Hippel–Lindau protein (pVHL) under normoxia.
Kim, Yong-Sung, Kim, Woo-Ho, S Kim, Daesung Shin, In Pyo Choi, Yong Sung Kim, Jeon, Jun-Ho, Kim, Seyl, Kim, Hyoung-Chin, J H Jeon, Hyun-Woo Suh, Jin Woong Chung, Shin, Daesung, Yoon, Suk Ran, Og Sung Moon, Jeong, Mira, Suk Ran Yoon, Mi Ra Jeong, W H Kim, Hyoung-Chin Kim, Choi, Inpyo, Chung, Jin Woong, Moon, Og-Sung, Suh, Hyun-Woo   +23 more
core   +1 more source

p32 is a negative regulator of p53 tetramerization and transactivation

Molecular Oncology, 2019
p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different tumor‐suppressive mechanisms.
Nikhil Baban Ghate, Jinman Kim, Yonghwan Shin, Alan Situ, Tobias S. Ulmer, Woojin An   +5 more
doaj   +1 more source