Results 121 to 130 of about 177,922 (281)
Mechanochromism of Glassy Polymers Enabled by a Loop‐Forming Supramolecular Mechanophore
Advanced Functional Materials, EarlyView.The supramolecular mechanophore LOOP is covalently introduced into glassy polymers, capable of reporting force‐induced pre‐failure damage and local fracture events in polymer glasses. Under different mechanical deformation modes, including grinding, tensile stretching, and scratching, LOOP probes irreversible events in polymer glasses through a ...
Linlin Deng +6 more
wiley +1 more source
PLoS ONEp62, an adapter protein involved in selective autophagy, is mainly found in the cytoplasm under normal conditions. Because p62 has nuclear localization signal (NLS) and a nuclear export signal, it has been suggested that p62 shuttles between the nucleus ...
Emi Kayama +8 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann +2 more
wiley +1 more source
The Disruption of a Nuclear Export Signal in the C-Terminus of the Herpes Simplex Virus 1 Determinant of Pathogenicity UL24 Protein Leads to a Syncytial Plaque Phenotype. [PDF]
Viruses, 2023 Gonzalez CE +2 more
europepmc +1 more source
Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy
Advanced Functional Materials, EarlyView.This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez +8 more
wiley +1 more source
, 2005 Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G. +3 more
core +2 more sources
Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks
Advanced Functional Materials, EarlyView.Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert +10 more
wiley +1 more source
Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain.
PLoS ONE, 2011 Proteins bearing a leucine-rich nuclear export signal (NES) are exported from the nucleus by the transport factor CRM1, which forms a cooperative ternary complex with the NES-bearing cargo and with the small GTPase Ran.
Karla Langer +4 more
doaj +1 more source
Herpes Simplex Virus-1 ICP27 Nuclear Export Signal Mutants Exhibit Cell Type-Dependent Deficits in Replication and ICP4 Expression. [PDF]
J Virol, 2023 Sanders LS +9 more
europepmc +1 more source
Advanced Functional Materials, EarlyView.A MXene/PEDOT coating enables multimodal functionality and dual‐analyte detection of dopamine and serotonin in flexible microelectrode arrays while enhancing electrophysiological recording quality. The anti‐fouling, low‐impedance interface overcomes key limitations of conventional coatings, providing a robust and versatile platform to investigate the ...
Ilaria Gatti +8 more
wiley +1 more source