Results 101 to 110 of about 2,137,659 (362)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]

, 2014
Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Aregger, Buratowski, Cansizoglu, Chook, Chu, Cowling, Cowling, Dormann, Fridell, Glover-Cutter, Gonatopoulos-Pournatzis, Lee, Li, Perales, Rebane, Shafer, Shatkin, Shuman, Suzuki, Süel, Thomas Gonatopoulos-Pournatzis, Topisirovic, Van Dusen, Victoria H. Cowling, Xu   +24 more
core   +4 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Targeting of the atToc159 Preprotein Receptor to the Chloroplast Outer Membrane is Mediated by its GTPase Domain and is Regulated by GTP [PDF]

, 2002
The multimeric translocon at the outer envelope membrane of chloroplasts (Toc) initiates the recognition and import of nuclear-encoded preproteins into chloroplasts.
Hiltbrunner, Andreas, Kessler, Felix, Schnell, Danny J., Smith, Matthew D.   +3 more
core   +2 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. [PDF]

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source

Heat Shock Protein 83 (Hsp83) Facilitates Methoprene-tolerant (Met) Nuclear Import to Modulate Juvenile Hormone Signaling*

Journal of Biological Chemistry, 2014
Background: Methoprene-tolerant (Met) and Germ-cell expressed belonging to the bHLH-PAS family have been identified as juvenile hormone (JH) receptors in Drosophila. Results: Physical interaction with Hsp83 facilitates nuclear import of Met and JH action.
Qianyu He, D. Wen, Qiangqiang Jia, Chunlai Cui, Jian Wang, S. R. Palli, Sheng Li   +6 more
semanticscholar   +1 more source

Nuclear Import of Viral DNA Genomes [PDF]

Traffic, 2003
The genomes of many viruses traffic into the nucleus, where they are either integrated into host chromosomes or maintained as episomal DNA and then transcriptionally activated or silenced. Here, we discuss the existing evidence on how the lentiviruses, adenoviruses, herpesviruses, hepadnaviruses and autonomous parvoviruses enter the nucleus.
Greber, U F, Fassati, A
openaire   +3 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Nucleocytoplasmic transport: a thermodynamic mechanism

, 2009
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion ...
Adam SA, Akey CW, Alber F, Bapteste E, Beck M, Becskei A, Ben‐Efraim I, Bickel T, Caspi Y, Catimel B, Cingolani G, Coppey M, Costa M, Cronshaw JM, Dange T, Denning DP, Devos D, Dixon M, Fanara P, Fradin C, Fradin C, Frey S, Grünwald D, Görlich D, Haldane JBS, Harreman MT, Henderson GP, Hinshaw JE, Hodel AE, Hu W, Hübner S, Jovanovic‐Talisman T, Kalab P, Kalderon D, Kapon R, Kobe B, Kopito RB, Kose S, Kotera I, Kubitscheck U, Kustanovich T, Köhler M, Lam MH, Lee SJ, Lyman SK, Mans BJ, Melcák I, Michael Elbaum, Michael WM, Miyamoto Y, Nachury MV, Naim B, Nakielny S, Newmeyer DD, Ossareh‐Nazari B, Pederson T, Pollard VW, Pyhtila B, Ribbeck K, Ribbeck K, Riddick G, Riddick G, Rihs HP, Robbins J, Ronen Benjamine Kopito, Rout MP, Salman H, Schmidt‐Zachmann MS, Schwartz TU, Shah S, Smith A, Stade K, Steggerda SM, Stein WD, Stoffler D, Strawn LA, Timney BL, Tokunaga M, Wen W, Yang Q, Yang W, Yang W, Zeitler B, Zilman A   +83 more
core   +2 more sources