The presence of heterogeneous nuclear ribonucleoproteins in frontotemporal lobar degeneration with FUS positive inclusions [PDF]
, 2016 Frontotemporal lobar degeneration with fused in sarcoma–positive inclusions (FTLD-FUS) is a disease with unknown cause. Transportin 1 is abundantly found in FUS-positive inclusions and responsible for the nuclear import of the FET proteins of which FUS ...
Bandopadhyay, R +4 more
core +1 more source
The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly. [PDF]
Emerg Microbes InfectLi X +8 more
europepmc +2 more sources
A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]
, 2015 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T +4 more
core +2 more sources
Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance A hexanucleotide repeat expansion in the first intron of the C9orf72 gene represents the most prominent form of heritable amyotrophic lateral sclerosis.
Kevin Shi +10 more
semanticscholar +1 more source
Biogenesis of mitochondrial c-type cytochromes [PDF]
, 1990 Cytochromesc andc 1 are essential components of the mitochondrial respiratory chain. In both cytochromes the heme group is covalently linked to the polypeptide chain via thioether bridges. The location of the two cytochromes is in the intermembrane space;
Gonzales, Daniel H., Neupert, Walter
core +2 more sources
Lamin Mutations Cause Increased YAP Nuclear Entry in Muscle Stem Cells
Cells, 2020 Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity.
Daniel J. Owens +6 more
doaj +1 more source
Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
Scientific Reports, 2018 ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol.
Emile S. Pinarbasi +5 more
semanticscholar +1 more source
Cells, 2022 Influenza viruses deliver their genome into the nucleus of infected cells for replication. This process is mediated by the viral nucleoprotein (NP), which contains two nuclear localization sequences (NLSs): NLS1 at the N-terminus and a recently ...
Nhan L. T. Nguyen, Nelly Panté
doaj +1 more source
Cytoplasmic transport and nuclear import of plasmid DNA
Bioscience Reports, 2017 Productive transfection and gene transfer require not simply the entry of DNA into cells and subsequent transcription from an appropriate promoter, but also a number of intracellular events that allow the DNA to move from the extracellular surface of the
Haiqing Bai +3 more
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source