Results 91 to 100 of about 163,417 (257)
LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer [PDF]
, 2015 LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer. It is local-ized in different cellular compartments, but its nuclear function has not been investigated so
Aceto +52 more
core +4 more sources
eLife, 2019 Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
Andrey Poleshko +9 more
doaj +1 more source
Segmentation of Lumen and External Elastic Laminae in Intravascular Ultrasound Images using Ultrasonic Backscattering Physics Initialized Multiscale Random Walks [PDF]
, 2019 Coronary artery disease accounts for a large number of deaths across the world and clinicians generally prefer using x-ray computed tomography or magnetic resonance imaging for localizing vascular pathologies. Interventional imaging modalities like intravascular ultrasound (IVUS) are used to adjunct diagnosis of atherosclerotic plaques in vessels, and ...
arxiv +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival [PDF]
, 2014 Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with
Breit, Claudia +14 more
core +1 more source
Nuclear envelope and chromatin choreography direct cellular differentiation
NucleusThe nuclear envelope plays an indispensable role in the spatiotemporal organization of chromatin and transcriptional regulation during the intricate process of cell differentiation.
Anjitha Nair +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.The study explores for the first time the use of polyvinyl butyral (PVB), particularly recycled PVB, as a sustainable binder for Li/Na‐based electrodes in the framework of the H2020 SUNRISE EU project. Findings revealed that electrodes bound with a sustainable PAA/PVB mixture demonstrated exceptional rate capability and high initial Coulombic ...
Hamideh Darjazi +4 more
wiley +1 more source
, 2016 The nucleus is arguably the defining characteristic of eukaryotes, distinguishing their cell organisation from both bacteria and archaea. Though the evolutionary history of the nucleus remains the subject of debate, its emergence differs from several ...
McCulloch, Richard, Navarro, Miguel
core +1 more source
Advanced Functional Materials, EarlyView.A visible light‐responsive polyacrylamide‐azobenzene hydrogel enables safe, reversible stiffness control for studying cell mechanobiology without harmful UV exposure. This approach reveals stem cells respond rapidly to mechanical changes, showing altered shape and protein distribution within one hour.
Aafreen Ansari +11 more
wiley +1 more source
The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers. [PDF]
, 2006 Hutchinson-Gilford progeria syndrome (HGPS) is a dominant autosomal premature aging syndrome caused by the expression of a truncated prelamin A designated progerin.
Buendia, Brigitte +5 more
core +1 more source