Results 101 to 110 of about 59,822 (282)
Advanced Healthcare Materials, EarlyView.A high‐resolution 3D‐printed tumor‐on‐a‐chip platform sustains breast cancer tissues at in vivo–like cell densities through vascular‐like perfusion. This engineered system recapitulates grade‐dependent molecular features and exhibits drug‐resistance profiles that uniquely align with clinically relevant Cmax values.
Geonhui Lee +3 more
wiley +1 more source
The effects of overexpression of lamin a and two mutants associated with premature aging on stem cell differentiation and proliferation. [PDF]
, 2007 The nuclear lamina is composed of A and B-type lamins and performs a number of functions within the nucleus. Mutations within lamins give rise to a group of diseases called laminopathies including autosomal dominant Emery-Dreifuss muscular dystrophy and ...
Gibbs-Seymour, Ian
core
Advanced Healthcare Materials, EarlyView.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett +7 more
wiley +1 more source
Subnuclear gene positioning through lamina association affects copper tolerance
Nature Communications, 2020 The nuclear lamina regulates chromatin organization and gene positioning. Here the authors show that CROWDED NUCLEI proteins contribute to the meshwork lamina structure in Arabidopsis nuclei and regulate copper tolerance by promoting lamina association ...
Yuki Sakamoto +12 more
doaj +1 more source
Lamin A/C as a prognostic biomarker in colorectal cancer [PDF]
, 2007 Lamins A and C (A-type lamins) are type V nuclear intermediate filament proteins which form a complex meshwork underlining the inner nuclear membrane termed the nuclear lamina.
Cox, Thomas Robert
core
Putative conserved mechanism of Pin1-induced nuclear lamina disassembly. [PDF]
, 2016 (A) Site-specific lamin phosphorylation by herpesvirus-encoded or host cell protein kinases. NEC, nuclear egress complex; PKC, protein kinase C; CDK, cyclin-dependent kinase.
Torgils Fossen (1632481) +10 more
core +1 more source
Advanced Materials, EarlyView.This study demonstrates a self‐assembly process to generate free‐standing piezoelectric nanomembranes, forming ultracompact microtubular acoustic wave sensors and actuators. The miniaturized 3D piezoelectric platform reported in this work can be applied in telecommunication, energy harvesting, and acoustofluidics. Moreover, the 3D self‐assembly can add
Raphaël C. L‐M. Doineau +9 more
wiley +1 more source
Investigating the role of nuclear myosin I in the low serum induced repositioning of chromosome 10 in interphase nuclei [PDF]
, 2010 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.The nucleus of mammalian cells has been proven to be highly organised.
Amira, Manelle
core
Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration
Advanced Materials, EarlyView.A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang +7 more
wiley +1 more source
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. [PDF]
, 2016 The nuclear lamina is a filamentous structure subtending the nuclear envelope and required for chromatin organization, transcriptional regulation and maintaining nuclear structure.
Aitchison, John D. +21 more
core +1 more source