Results 81 to 90 of about 111,707 (190)

The nuclear lamina during human spermiogenesis [PDF]

Orphanet Journal of Rare Diseases, 2015
The nuclear lamina takes centre stage during spermiogenesis, the post-meiotic phase of spermatogenesis, when haploid round spermatids differentiate into spermatozoa: the acrosome and flagellum develop at opposite nuclear poles, the nucleus elongates and, as the nuclear histones are replaced with protamines, the chromatin condenses, to produce the ...
openaire   +1 more source

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

eLife, 2019
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
Andrey Poleshko, Cheryl L Smith, Son C Nguyen, Priya Sivaramakrishnan, Karen G Wong, John Isaac Murray, Melike Lakadamyali, Eric F Joyce, Rajan Jain, Jonathan A Epstein   +9 more
doaj   +1 more source

Internal iamin structures within G1 nuclei of human dermal fibroblasts [PDF]

, 1993
The nuclear lamina is a mesh-like network of fibres subjacent to the inner nuclear membrane that is believed to be involved in the specific spatial reorganisation of chromatin after mitosis.
Bridger, JM, Hutchison, CJ, Kill, IR, O’Farrell, M   +3 more
core  

From lamins to lamina: a structural perspective [PDF]

, 2018
Lamin proteins are the major constituents of the nuclear lamina, a proteinaceous network that lines the inner nuclear membrane. Primarily, the nuclear lamina provides structural support for the nucleus and the nuclear envelope; however, lamins and their ...
Medalia, Ohad, Zwerger, Monika
core  

The isolation of the nuclear lamina [PDF]

The Journal of Cell Biology, 2005
The number of monikers early cell biologists attached to the nuclear lamina reflected their uncertainty about its function and architecture, and whether it was widespread or confined to a few specialized cells. Electron micrographs often disclosed a layer of varying thickness nestled against the backside of the nuclear membrane, which various ...
openaire   +1 more source

Subnuclear gene positioning through lamina association affects copper tolerance

Nature Communications, 2020
The nuclear lamina regulates chromatin organization and gene positioning. Here the authors show that CROWDED NUCLEI proteins contribute to the meshwork lamina structure in Arabidopsis nuclei and regulate copper tolerance by promoting lamina association ...
Yuki Sakamoto, Mayuko Sato, Yoshikatsu Sato, Akihito Harada, Takamasa Suzuki, Chieko Goto, Kentaro Tamura, Kiminori Toyooka, Hiroshi Kimura, Yasuyuki Ohkawa, Ikuko Hara-Nishimura, Shingo Takagi, Sachihiro Matsunaga   +12 more
doaj   +1 more source

Evolution: functional evolution of nuclear structure. [PDF]

, 2011
The evolution of the nucleus, the defining feature of eukaryotic cells, was long shrouded in speculation and mystery. There is now strong evidence that nuclear pore complexes (NPCs) and nuclear membranes coevolved with the endomembrane system, and that ...
Dawson, Scott C, Wilson, Katherine L
core  

Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.

PLoS Pathogens, 2009
The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress).
Sofia Hamirally, Jeremy P Kamil, Yasmine M Ndassa-Colday, Alison J Lin, Wan Jin Jahng, Moon-Chang Baek, Sarah Noton, Laurie A Silva, Martha Simpson-Holley, David M Knipe, David E Golan, Jarrod A Marto, Donald M Coen   +12 more
doaj   +1 more source

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar, Jaroslaw Paturej, Edward J. Banigan, Aykut Erbaş   +3 more
doaj   +1 more source

The nexus of nuclear envelope dynamics, circular economy and cancer cell pathophysiology

European Journal of Cell Biology
The nuclear envelope (NE) is a critical component in maintaining the function and structure of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to enable an open mitosis.
Kristina Keuper, Jiri Bartek, Apolinar Maya-Mendoza   +2 more
doaj   +1 more source