Results 61 to 70 of about 111,707 (190)

Local rewiring of genome - nuclear lamina interactions by transcription [PDF]

The EMBO Journal, 2019
AbstractTranscriptionally inactive genes are often positioned at the nuclear lamina (NL), as part of large lamina-associated domains (LADs). Activation of such genes is often accompanied by repositioning towards the nuclear interior. How this process works and how it impacts flanking chromosomal regions is poorly understood.
Brueckner, Laura, Zhao, Peiyao A, van Schaik, Tom, Leemans, Christ, Sima, Jiao, Peric‐Hupkes, Daniel, Gilbert, David M, van Steensel, Bas   +7 more
openaire   +3 more sources

Major nuclear locales define nuclear genome organization and function beyond A and B compartments

eLife
Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here, we integrated analysis of sequencing and image-based data to compare genome organization in four ...
Omid Gholamalamdari, Tom van Schaik, Yuchuan Wang, Pradeep Kumar, Liguo Zhang, Yang Zhang, Gabriela A Hernandez Gonzalez, Athanasios E Vouzas, Peiyao A Zhao, David M Gilbert, Jian Ma, Bas van Steensel, Andrew S Belmont   +12 more
doaj   +1 more source

Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes

mBio, 2012
Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by heterochromatin.
Lindsey Silva, Hyung Suk Oh, Lynne Chang, Zhipeng Yan, Steven J. Triezenberg, David M. Knipe   +5 more
doaj   +1 more source

Need for NAD⁺: Focus on Striated Muscle Laminopathies

Cells, 2020
Laminopathies are a heterogeneous group of rare diseases caused by genetic mutations in the LMNA gene, encoding A-type lamins. A-type lamins are nuclear envelope proteins which associate with B-type lamins to form the nuclear lamina, a meshwork ...
Déborah Cardoso, Antoine Muchir
doaj   +1 more source

Putting the genome on the map [PDF]

, 1998
The maps of our everyday lives are much more than just linear lists of place names. Instead, their colours, symbols, contours and grid lines seek to describe different types of landscape, and to depict the spatial relationships between structural and ...
Andrulis, Baumgartner, Belmont, Bickmore, Blencowe, Boddy, Boy de la Tour, Brett, Bridger, Bridger, Brown, Buchenau, Capco, Carter, Clemson, Craig, Craig, Craig, Cremer, Cross, Csink, Dernburg, Dietzel, Dobie, Eils, Ferguson, Ferreira, Festenstein, Foisner, Fox, Gerdes, Gotta, Heck, Hernandez-Verdun, Hozak, Imai, Jackson, Jackson, Jeppesen, Kill, Krystosek, Kurz, LaSalle, Lawlis, Leitch, Li, Linares-Cruz, Maillet, Marshall, McQueen, Milot, Mortillaro, Nagele, O'Keefe, Paillsson, Paulson, Pombo, Pyrpasopoulou, Razin, Razin, Robinett, Saccone, Sachs, Saitoh, Satijn, Shelby, Taniura, Vourc'h, Weitspolthammer, Ye, Yokota, Zink, Zirbel   +72 more
core   +1 more source

Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]

, 2015
Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane, Mozzetta, Chiara, Pontis, Julien   +2 more
core   +2 more sources

The Nuclear Lamina as a Gene-silencing Hub [PDF]

Current Issues in Molecular Biology, 2012
There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Shevelyov, Yuri Y., Nurminsky, Dmitry I.
openaire   +2 more sources

Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD

Acta Neuropathologica Communications, 2021
The most common genetic cause of familial and sporadic amyotrophic lateral sclerosis (ALS) is a GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 gene.
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj   +1 more source

Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. [PDF]

, 1988
A cDNA clone encoding a portion of Drosophila nuclear lamins Dm1 and Dm2 has been identified by screening a lambda-gt11 cDNA expression library using Drosophila lamin-specific monoclonal antibodies.
Bare, JW, Benton, BM, Drees, B, Fisher, PA, Gruenbaum, Y, Landesman, Y, Paddy, MR, Saumweber, H, Sedat, JW, Smith, DE   +9 more
core   +1 more source

A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties [PDF]

, 2017
The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal V gamma 3 T cells, intestinal intraepithelial CD8 alpha alpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells.
Biswas, Aindrila, Diefenbach, Andreas, Dunay, Ildiko Rita, Filtjens, Jessica, Gronke, Konrad, Kerre, Tessa, Leclercq, Georges, Martens, Liesbet, Matthys, Patrick, Plum, Jean, Saeys, Yvan, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Vandekerckhove, Bart   +15 more
core   +2 more sources