Results 61 to 70 of about 59,822 (282)

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status.
Ishita S Mehta, Bridger, JM, Joanna M Bridger, Mehta, IS, Manelle Amira, Harvey, AJ, Amira, M, Amanda J Harvey   +7 more
core   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source

Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization

Nature Communications
Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization.
Ting-Ching Wang, Samere Abolghasemzade, Brendan P. McKee, Ishita Singh, Kavya Pendyala, Mohammad Mohajeri, Hailee Patel, Aakansha Shaji, Anna L. Kersey, Kajol Harsh, Simran Kaur, Christina R. Dollahon, Sasanka Chukkapalli, Pushkar P. Lele, Daniel E. Conway, Akhilesh K. Gaharwar, Richard B. Dickinson, Tanmay P. Lele   +17 more
doaj   +1 more source

Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells

Nucleus, 2020
The nuclear lamina is a meshwork of intermediate filament proteins, and lamin A is the primary mechanical protein. An altered splicing of lamin A, known as progerin, causes the disease Hutchinson-Gilford progeria syndrome.
Brooke E. Danielsson, Katie V. Tieu, Kranthidhar Bathula, Travis J. Armiger, Pragna S. Vellala, Rebecca E. Taylor, Kris Noel Dahl, Daniel E. Conway   +7 more
doaj   +1 more source

Robust Electrocaloric Performance Enabled by Highly‐Polar Frustrated Nanodomains in NaNbO3‐Based Ferrodistortive Relaxor

Advanced Functional Materials, EarlyView.
P4bm framework in NaNbO3‐Ba(Ti, Hf)O3 ferrodistortive relaxor entails short‐range and highly‐polar ferrodistortive orders. The abundant highly‐polar orders facilitate to increase entropy change, and robust octahedral oxygen tilt enables to impede thermal perturbations.
Feng Li, Changshun Dai, He Qi, Jiecheng Liu, Xiaoming Shi, Heng Zhou, Qiong Yang, Mingsheng Long, Lei Shan, Chunchang Wang, Jianli Wang, Zhenxiang Cheng   +11 more
wiley   +1 more source

Major nuclear locales define nuclear genome organization and function beyond A and B compartments

eLife
Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here, we integrated analysis of sequencing and image-based data to compare genome organization in four ...
Omid Gholamalamdari, Tom van Schaik, Yuchuan Wang, Pradeep Kumar, Liguo Zhang, Yang Zhang, Gabriela A Hernandez Gonzalez, Athanasios E Vouzas, Peiyao A Zhao, David M Gilbert, Jian Ma, Bas van Steensel, Andrew S Belmont   +12 more
doaj   +1 more source

Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes

mBio, 2012
Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by heterochromatin.
Lindsey Silva, Hyung Suk Oh, Lynne Chang, Zhipeng Yan, Steven J. Triezenberg, David M. Knipe   +5 more
doaj   +1 more source

Discovery and restoration of Aberrant Nuclear structure and Genome behaviour in breast cancer cells [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The eukaryotic interphase nucleus is well organised and the genome positioned non-randomly.
Hassan Ahmed, Mai
core  

Structural studies on protein scaffolds related to muscle physiology and disease : the titin filament, its associated component MuRF-1 and nuclear LAP2[alpha] [PDF]

, 2006
The titin molecule has a length of overµm and functions as a colossal protein scaffold in the muscle sarcomere. Up to 90% of its total mass is composed of repetitive immunoglobulin (Ig) and fibronectin (FnIII) domains that form linear tandems ...
Mrosek, Michael Christian
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source