Results 191 to 200 of about 59,822 (282)

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Telomeres, the nuclear lamina, and membrane remodeling: Orchestrating meiotic chromosome movements. [PDF]

J Cell Biol
Shibuya H.
europepmc   +1 more source

A method to map the interaction network of the nuclear lamina with genetically encoded photo-crosslinkers in vivo. [PDF]

Front Chem, 2022
Neumann-Staubitz P, Kitsberg D, Buxboim A, Neumann H.   +3 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Mixed‐Polymer Hole Transport Layers Reinforce Au‐Anode Top Emitting Perovskite Light Emitting Diodes

Advanced Science, EarlyView.
Au‐anode corrosion is shown to occur rapidly under voltage bias in MAPbI3 perovskite LEDs. Resulting Au+ migration quickly leads to device shorting and unstable emission during constant current driving. We demonstrate that using a simple mixed‐polymer hole transport layer containing polyTPD and PVK can reduce Au‐corrosion and stabilize LED operation ...
James C. Loy, Jisu Hong, Tuo Hu, Xu He, Antoine Kahn, Barry P. Rand   +5 more
wiley   +1 more source

Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions. [PDF]

Sci Adv
McKee B, Abolghasemzade S, Wang TC, Harsh K, Kaur S, Blanchard R, Menon KB, Mohajeri M, Dickinson RB, Lele TP.   +9 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Conserved mode of nuclear lamina distortion by primate cytomegaloviruses: importance of the pSer22 motif, viral kinase and <i>cis</i>/<i>trans</i> isomerase Pin1 activity. [PDF]

J Gen Virol
Dhotre K, Schütz M, von Essen S, Fortelny L, Wangen C, Hahn F, Sticht H, Marschall M.   +7 more
europepmc   +1 more source

Electrocatalytic Coupling Conversion of Methane by Dual‐Site Control in Nickel Oxyhydroxide

Advanced Science, EarlyView.
Electrocatalytic coupling conversion of methane (CH4) is accomplished on the nickel oxyhydroxide (NiOOH), wherein the Ni─O dual‐site is triggered via the proper electronic interaction, synergistically promoting the C─H activation and C─C formation, enabling a selective and efficient C2 product generation route under ambient conditions. ABSTRACT Methane
Kailong Lu, Yangshen Chen, Junhao Wang, Yi Zhang, Sunyang He, Huimin Xu, Hui Liu, Jiao Deng   +7 more
wiley   +1 more source

Binding of Transcriptional Activator to Silent Loci Causes Their Detachment from the Nuclear Lamina in <i>Drosophila</i> Neurons and Salivary Gland Cells. [PDF]

Int J Mol Sci
Simonov RA, Olenkina OM, Nenasheva VV, Abramov YA, Lavrov SA, Fedotova AA, Shevelyov YY.   +6 more
europepmc   +1 more source