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A new model for nuclear lamina organization
Biochemical Society Transactions, 2008Lamins are intermediate filament proteins that form a network lining the inner nuclear membrane. They provide mechanical strength to the nuclear envelope, but also appear to have many other functions as reflected in the array of diseases caused by lamin mutations.
Martin W, Goldberg +3 more
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Inner nuclear membrane proteins and the nuclear lamina
Journal of Cell Science, 2001The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors.
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Organization and modulation of nuclear lamina structure
Journal of Cell Science, 1984ABSTRACT The nuclear lamina is a protein meshwork associated with the nucleoplasmic surface of the inner nuclear membrane, that is suggested to be important for organizing nuclear envelope and interphase chromosome architecture. To investigate the structural organization of the lamina, we have analysed rat liver nuclear envelopes by ...
L, Gerace, C, Comeau, M, Benson
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Nuclear lamina and regulation of nuclear envelofe structure
Proceedings, annual meeting, Electron Microscopy Society of America, 1987The nuclear lamina is a protein meshwork that lines the nucleoplasmic surface of the nuclear envelope. In numerous higher eukaryotic cells, the lamina is known to contain a polymer of 1-3 major polypeptides (“lamins“) that form an insoluble supramolecular assembly during interphase.
Larry Gerace +3 more
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Relation between nuclear envelope and nuclear lamina in nuclear assemblyin vitro
Science in China Series C: Life Sciences, 1997Xenopus laevis egg extracts cell-free nuclear assembly system was used as an experimental model to study the process of nuclear lamina assembly in nuclear reconstitution in vitro. The experimental results showed that lamin was involved in the nuclear assembly in vitro.
S, Cai, Z, Zhai
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The Nuclear Lamina and Its Functions in the Nucleus
2003The nuclear lamina is a structure near the inner nuclear membrane and the peripheral chromatin. It is composed of lamins, which are also present in the nuclear interior, and lamin-associated proteins. The increasing number of proteins that interact with lamins and the compound interactions between these proteins and chromatin-associated proteins make ...
Yosef, Gruenbaum +8 more
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The nuclear lamina in health and disease
2022The nuclear lamina (NL) is a structural component of the nuclear envelope and makes extensive contacts with integral nuclear membrane proteins and chromatin. These interactions are critical for many cellular processes, such as nuclear positioning, perception of mechanical stimuli from the cell surface, nuclear stability, 3-dimensional organisation of ...
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Local rewiring of genome–nuclear lamina interactions by transcription
EMBO Journal, 2020Tom Van Schaik +2 more
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