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Functional mechanisms and abnormalities of the nuclear lamina
Nature Cell Biology, 2021Alterations in nuclear shape are present in human diseases and ageing. A compromised nuclear lamina is molecularly interlinked to altered chromatin functions and genomic instability. Whether these alterations are a cause or a consequence of the pathological state are important questions in biology.
Adam Karoutas, Asifa Akhtar
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The Nuclear Lamina and Its Functions in the Nucleus
International Review of Cytology, 2003The nuclear lamina is a structure near the inner nuclear membrane and the peripheral chromatin. It is composed of lamins, which are also present in the nuclear interior, and lamin-associated proteins. The increasing number of proteins that interact with lamins and the compound interactions between these proteins and chromatin-associated proteins make ...
Yosef Gruenbaum +2 more
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Immunological analysis of nuclear lamina proteins
Chromosoma, 1980Antibodies have been obtained against specific fractions of the nuclear lamina from chick red blood cells. Immunofluorescent staining of acrylamide gels from nuclear lamina preparations revealed a spectrum of at least 8-10 proteins cross-reacting immunologically with each other.
R, Stick, P, Hausen
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Mechanisms of nuclear lamina growth in interphase
Histochemistry and Cell Biology, 2016The nuclear lamina represents a multifunctional platform involved in such diverse yet interconnected processes as spatial organization of the genome, maintenance of mechanical stability of the nucleus, regulation of transcription and replication. Most of lamina activities are exerted through tethering of lamina-associated chromatin domains (LADs) to ...
Oxana A, Zhironkina +6 more
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The Role of the Nuclear Lamina in Cancer and Apoptosis
2014Not long after the discovery of lamin proteins, it became clear that not all lamin subtypes are ubiquitously expressed in cells and tissues. Especially, A-type lamins showed an inverse correlation with proliferation and were thus initially called statins.
Broers, Jos, Ramaekers, Frans
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A new model for nuclear lamina organization
Biochemical Society Transactions, 2008Lamins are intermediate filament proteins that form a network lining the inner nuclear membrane. They provide mechanical strength to the nuclear envelope, but also appear to have many other functions as reflected in the array of diseases caused by lamin mutations.
Martin W, Goldberg +3 more
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Inner nuclear membrane proteins and the nuclear lamina
Journal of Cell Science, 2001The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors.
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The nuclear lamina and heterochromatin: a complex relationship
Biochemical Society Transactions, 2011In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of ...
Erin M, Bank, Yosef, Gruenbaum
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Organization and modulation of nuclear lamina structure
Journal of Cell Science, 1984ABSTRACT The nuclear lamina is a protein meshwork associated with the nucleoplasmic surface of the inner nuclear membrane, that is suggested to be important for organizing nuclear envelope and interphase chromosome architecture. To investigate the structural organization of the lamina, we have analysed rat liver nuclear envelopes by ...
L, Gerace, C, Comeau, M, Benson
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Relation between nuclear envelope and nuclear lamina in nuclear assemblyin vitro
Science in China Series C: Life Sciences, 1997Xenopus laevis egg extracts cell-free nuclear assembly system was used as an experimental model to study the process of nuclear lamina assembly in nuclear reconstitution in vitro. The experimental results showed that lamin was involved in the nuclear assembly in vitro.
S, Cai, Z, Zhai
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