Results 61 to 70 of about 163,417 (257)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Robust nuclear lamina-based cell classification of aging and senescent cells [PDF]

, 2011
Changes in the shape of the nuclear lamina are exhibited in senescent cells, as well as in cells expressing mutations in lamina genes. To identify cells with defects in the nuclear lamina we developed an imaging method that quantifies the intensity and ...
Raz, Vered, Righolt, Christiaan H., van 't Hoff, Merel L.R., Vermolen, Bart J., Young, Ian T.   +4 more
core   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization

Nature Communications
Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization.
Ting-Ching Wang, Samere Abolghasemzade, Brendan P. McKee, Ishita Singh, Kavya Pendyala, Mohammad Mohajeri, Hailee Patel, Aakansha Shaji, Anna L. Kersey, Kajol Harsh, Simran Kaur, Christina R. Dollahon, Sasanka Chukkapalli, Pushkar P. Lele, Daniel E. Conway, Akhilesh K. Gaharwar, Richard B. Dickinson, Tanmay P. Lele   +17 more
doaj   +1 more source

Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale

Nucleus, 2021
Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear.
Annaël Brunet, Nicolas Destainville, Philippe Collas   +2 more
doaj   +1 more source

Fractality and Topology of Self-Avoiding Walks [PDF]

arXiv, 2020
We have analyzed geometric and topological features of self-avoiding walks. We introduce a new kind of walk: the loop-deleted self-avoiding walk (LDSAW) motivated by the interaction of chromatin with the nuclear lamina. Its critical exponent is calculated and found to be different from that of the ordinary SAW.
arxiv  

An Examination of Aerosol Jet‐Printed Surface Roughness and its Impact on the Performance of High‐Frequency Electronics

Advanced Engineering Materials, EarlyView.
This study explores aerosol jet‐printed (AJP) surface roughness, its effects on the performance of microwave electronics, and its process contributors. First, an electromagnetic model is vetted for AJP's unique roughness signature. Simulations are built which show process‐induced roughness is as significant as conductor resistivity in driving microwave
Christopher Areias, Alkim Akyurtlu
wiley   +1 more source

Preparation of nuclear matrices from cultured cells: subfractionation of nuclei in situ [PDF]

, 1984
Analyses of the different structural systems of the nucleus and the proteins associated with them pose many problems. Because these systems are largely overlapping, in situ localization studies that preserve the in vivo location of proteins and cellular ...
Deppert, Wolfgang, Staufenbiel, Matthias
core   +2 more sources

Bat Optimized Watershed based Segmentation of Lamina Cribrosa [PDF]

arXiv, 2020
The segmentation of Lamina Cribrosa(LC) is a challenging task to detect the glaucomatous damage. In this paper a new method of segmenting the LC using bat optimized Watershed segmentation is done. By using wavelet transform LC structures are decomposed.
arxiv  

Stars Bisected by Relativistic Blades [PDF]

arXiv, 2023
We consider the dynamics of an equatorial explosion powered by a millisecond magnetar formed from the core collapse of a massive star. We study whether these outflows -- generated by a priori magneto-centrifugally-driven, relativistic magnetar winds -- might be powerful enough to produce an ultra-relativistic blade ("lamina") that successfully carves ...
arxiv