Results 61 to 70 of about 1,676,612 (335)
PLoS Genetics, 2013 The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape.
Jana Link +7 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The nuclear lamina is an integral component of all metazoan cells. While the individual constituents of the nuclear lamina, the A- and B-type lamins, have been well studied, whether they exhibit a distinct spatial organization is unclear ...
Bruce Nmezi +14 more
semanticscholar +1 more source
Restructuring of Lamina-Associated Domains in Senescence and Cancer
Cells, 2022 Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger +3 more
doaj +1 more source
Preparation of nuclear matrices from cultured cells: subfractionation of nuclei in situ [PDF]
, 1984 Analyses of the different structural systems of the nucleus and the proteins associated with them pose many problems. Because these systems are largely overlapping, in situ localization studies that preserve the in vivo location of proteins and cellular ...
Deppert, Wolfgang, Staufenbiel, Matthias
core +2 more sources
Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms
Epigenetics & Chromatin, 2022 The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation in several cell lines including Huh7.
Ya-Hui Chi +5 more
doaj +1 more source
Pushing the (nuclear) envelope into meiosis. [PDF]
, 2013 A recent study shows that a short isoform of a mammalian nuclear lamin is important for homologous chromosome interactions during meiotic prophase in ...
Dernburg, Abby F
core +1 more source
Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]
, 2004 Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Bridger, JM, Kill, IR
core +1 more source
Genome organization in cardiomyocytes expressing mutated A-type lamins
Frontiers in Cell and Developmental Biology, 2022 Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly
Marie Kervella +3 more
doaj +1 more source
The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation [PDF]
, 2016 Lamin A is a component of the nuclear matrix that also controls proliferation by largely unknown mechanisms. NF-Y is a ubiquitous protein involved in cell proliferation composed of three subunits (-YA -YB -YC) all required for the DNA ...
Alonzi, Tonino +16 more
core +2 more sources
mBio, 2015 We have shown previously that A-type lamins and intranuclear localization of the herpes simplex virus (HSV) genome are critical for the formation of the VP16 activator complex on HSV immediate-early (IE) gene promoters in murine cells, which implies a ...
Hyung Suk Oh +2 more
doaj +1 more source