Results 91 to 100 of about 929,541 (348)
Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]
PLoS ONE, 2012 Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Johannes Matschke +5 more
doaj +1 more source
Up‐regulation of nuclear protein import by nuclear localization signal sequences in living cells [PDF]
FEBS Letters, 1999 Using an in vivo assay system, nuclear import ability in individual cells was determined by examining the nuclear import rate. It was found that when a small (not excess) amount of SV40 T‐NLS peptides was co‐injected, the nuclear import rate of SV40 T‐NLS‐containing substrates apparently increased.
Yoshihiro Yoneda +2 more
openaire +3 more sources
Quenching star formation: insights from the local main sequence [PDF]
, 2015 The so-called star-forming main sequence of galaxies is the apparent tight relationship between the star formation rate and stellar mass of a galaxy. Previous studies exclude galaxies which are not strictly 'star forming' from the main sequence, because they do not lie on the same tight relation.
arxiv +1 more source
Nuclear Spins in Nanostructures [PDF]
Physica Status Solidi B 246, 2203 (2009), 2009 We review recent theoretical and experimental advances toward understanding the effects of nuclear spins in confined nanostructures. These systems, which include quantum dots, defect centers, and molecular magnets, are particularly interesting for their importance in quantum information processing devices, which aim to coherently manipulate single ...
arxiv +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Nuclear localization of the transcriptional regulator MIER1α requires interaction with HDAC1/2 in breast cancer cells. [PDF]
PLoS ONE, 2013 MIER1α is a transcriptional regulator that functions in gene repression through its ability to interact with various chromatin modifiers and transcription factors. We have also shown that MIER1α interacts with ERα and inhibits estrogen-stimulated growth.
Shengnan Li +2 more
doaj +1 more source
Nuclear Spins as Quantum Memory in Semiconductor Nanostructures [PDF]
Phys. Rev. B 76, 045218 (2007), 2007 We theoretically consider solid state nuclear spins in a semiconductor nanostructure environment as long-lived, high-fidelity quantum memory. In particular, we calculate, in the limit of a strong applied magnetic field, the fidelity versus time of P donor nuclear spins in random bath environments of Si and GaAs, and the lifetime of excited intrinsic ...
arxiv +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Cell Communication and Signaling, 2012 Background ADP-ribosylation is a posttranslational modification catalyzed in cells by ADP-ribosyltransferases (ARTD or PARP enzymes). The ARTD family consists of 17 members. Some ARTDs modify their substrates by adding ADP-ribose in an iterative process,
Kleine Henning +12 more
doaj +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source