Results 91 to 100 of about 519,246 (298)

The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. [PDF]

PLoS ONE, 2015
Translocation to the nucleus of diacylglycerol kinase (DGK)- ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus.
Timothy D Rohrbach, Nishi Shah, William P Jackson, Erin V Feeney, Samantha Scanlon, Robert Gish, Ryan Khodadadi, Stephen O Hyde, Patricia H Hicks, Joshua C Anderson, John S Jarboe, Christopher D Willey   +11 more
doaj   +1 more source

The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway [PDF]

, 2009
© 2009 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Höfken, Thomas, Jacquier, Nicolas, Just, Ursula, Lin, Meng, Schneiter, Roger, Unden, Heike   +5 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Changing course: Glucose starvation drives nuclear accumulation of Hexokinase 2 in S. cerevisiae.

PLoS Genetics, 2023
Glucose is the preferred carbon source for most eukaryotes, and the first step in its metabolism is phosphorylation to glucose-6-phosphate. This reaction is catalyzed by hexokinases or glucokinases.
Mitchell A Lesko, Dakshayini G Chandrashekarappa, Eric M Jordahl, Katherine G Oppenheimer, Ray W Bowman, Chaowei Shang, Jacob D Durrant, Martin C Schmidt, Allyson F O'Donnell   +8 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Characterization of the Nucleocytoplasmic Transport Mechanisms of Epstein-Barr Virus BFLF2

Cellular Physiology and Biochemistry, 2018
Background/Aims: Epstein-Barr virus (EBV) BFLF2, the homologue of herpes simplex virus 1 (HSV-1) UL31, is crucial for the efficient viral DNA packaging and primary egress across the nuclear membrane.
Meili Li, Tao Chen, Xingmei Zou, Zuo Xu, Yuanfang Wang, Ping Wang, Xiaowen Ou, Yiwen Li, Daixiong Chen, Tao Peng, Yao Wang, Mingsheng Cai   +11 more
doaj   +1 more source

Duck enteritis virus pUL47, as a late structural protein localized in the nucleus, mainly depends on residues 40 to 50 and 768 to 777 and inhibits IFN-β signalling by interacting with STAT1

Veterinary Research, 2020
Duck enteritis virus (DEV) is a member of the Alphaherpesvirinae subfamily. The characteristics of some DEV genes have been reported. However, information regarding the DEV UL47 gene is limited.
Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Renyong Jia, Ying Wu, Juan Huang, Shun Chen, Xin-Xin Zhao, Mafeng Liu, Dekang Zhu, Shaqiu Zhang, Xuming Ou, Sai Mao, Qun Gao, Di Sun, XinJian Wen, Bin Tian, Yunya Liu, Yanling Yu, Ling Zhang, Leichang Pan, Xiaoyue Chen   +22 more
doaj   +1 more source

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture [PDF]

, 2009
Pyrrole−imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture.
Dervan, Peter B., Jacobs, Claire S.
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

SUMOylation of nuclear actin [PDF]

, 2009
Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport.
Alessandro Arduini, Aslan, Ball, Camacho, Camacho, Carlos J. Camacho, Chik, Chuang, Comeau, Comeau, Dantan-Gonzalez, Dignam, dos Remedios, Dundr, Field, Frances V. Fuller-Pace, Hay, Hofmann, Hofmann, Jacobs, James L. Lessard, Jockusch, Johnson, Kalderon, Karakozova, Kozakov, Kudo, Kudryashova, Lin, Lorenz, Louvet, Mandell, Matic, Matsuzaki, McDonald, Panse, Pendleton, Pestic-Dragovich, Posern, Primal de Lanerolle, Reverter, Rodriguez, Rosas-Acosta, Samantha M. Nicol, Schoenenberger, Schoenenberger, Stuven, Thom, Vertegaal, Wada, Wang, Westphal, Wilma A. Hofmann   +52 more
core   +5 more sources