Results 91 to 100 of about 709,714 (368)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Prediction of nuclear proteins using nuclear translocation signals proposed by probabilistic latent semantic indexing

BMC Bioinformatics, 2012
Background Identification of subcellular localization in proteins is crucial to elucidate cellular processes and molecular functions in a cell. However, given a tremendous amount of sequence data generated in the post-genomic era, determining protein ...
Su Emily, Chang Jia-Ming, Cheng Cheng-Wei, Sung Ting-Yi, Hsu Wen-Lian   +4 more
doaj   +1 more source

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

BMC Cell Biology, 2008
Background The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlled by protein-protein interactions.
Valovka Taras, Hassa Paul O, Altmeyer Matthias, Haenni Sandra S, Fey Monika, Hottiger Michael O   +5 more
doaj   +1 more source

A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]

PLoS ONE, 2011
The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
doaj   +1 more source

Nuclear localization of mouse fibroblast growth factor 2 requires N-terminal and C-terminal sequences [PDF]

, 2018
In vertebrates, different isoforms of fibroblast growth factor 2 (FGF2) exist, which differ by their N-terminal extension. They show different localization and expression levels and exert distinct biological effects. Nevertheless, genetic inactivation of
Beermann, F., Foletti, A., Vuadens, F.
core  

TFIIIC Localizes Budding Yeast ETC Sites to the Nuclear Periphery [PDF]

, 2012
Peer reviewedPublisher ...
Botsios, Sotirios, Donaldson, Anne Dunlop, Donze, David, Hiraga, Shinichiro   +3 more
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Up‐regulation of nuclear protein import by nuclear localization signal sequences in living cells [PDF]

FEBS Letters, 1999
Using an in vivo assay system, nuclear import ability in individual cells was determined by examining the nuclear import rate. It was found that when a small (not excess) amount of SV40 T‐NLS peptides was co‐injected, the nuclear import rate of SV40 T‐NLS‐containing substrates apparently increased.
Yoshihiro Yoneda, Miki Hieda, Taro Tachibana   +2 more
openaire   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Journal of Translational Medicine, 2019
Background Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay between the stress response and the gene
Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani, Gabriella Guida   +12 more
doaj   +1 more source