Results 111 to 120 of about 292,166 (318)

Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments

, 1999
The influenza virus genome is transcribed in the nuclei of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidates genomic RNA to ...
Pope, Brian, Digard, Paul, Medcalf, Liz, Weeds, Alan, Elton, Debra, Bishop, Konrad   +5 more
core  

Characterization of the Nucleocytoplasmic Transport Mechanisms of Epstein-Barr Virus BFLF2

Cellular Physiology and Biochemistry, 2018
Background/Aims: Epstein-Barr virus (EBV) BFLF2, the homologue of herpes simplex virus 1 (HSV-1) UL31, is crucial for the efficient viral DNA packaging and primary egress across the nuclear membrane.
Meili Li, Tao Chen, Xingmei Zou, Zuo Xu, Yuanfang Wang, Ping Wang, Xiaowen Ou, Yiwen Li, Daixiong Chen, Tao Peng, Yao Wang, Mingsheng Cai   +11 more
doaj   +1 more source

Duck enteritis virus pUL47, as a late structural protein localized in the nucleus, mainly depends on residues 40 to 50 and 768 to 777 and inhibits IFN-β signalling by interacting with STAT1

Veterinary Research, 2020
Duck enteritis virus (DEV) is a member of the Alphaherpesvirinae subfamily. The characteristics of some DEV genes have been reported. However, information regarding the DEV UL47 gene is limited.
Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Renyong Jia, Ying Wu, Juan Huang, Shun Chen, Xin-Xin Zhao, Mafeng Liu, Dekang Zhu, Shaqiu Zhang, Xuming Ou, Sai Mao, Qun Gao, Di Sun, XinJian Wen, Bin Tian, Yunya Liu, Yanling Yu, Ling Zhang, Leichang Pan, Xiaoyue Chen   +22 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fungal CSL transcription factors [PDF]

, 2007
Background: The CSL (CBF1/RBP-J kappa/Suppressor of Hairless/LAG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan development. They function as
Prevorovsky, M, Folk Petr, Folk, P, Puta, F, Půta František, Převorovský Martin   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3

, 2008
ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
Wenbo Lin, Yiling Lu, In Soon Chang, Robert Bast, Jr., Warren Liao, Shaoyi Huang, Zhen Lu, Tao Tao, Ke Zhang, Robert Luo, Yinhua Yu, Xiaomin Chen   +11 more
core  

Sps1 has a nuclear localization sequence.

, 2014
(A) Diagram of Sps1 indicating potential nuclear localization signals. The first KRKPPK (231–236) lies within the kinase domain and the second, KKHKK (411–415) is located toward the C-terminus.
Christian J. Slubowski (663471), Scott M. Paulissen (663472), Linda S. Huang (663473)   +2 more
core   +1 more source

Non-Covalent Loading of Anti-Cancer Doxorubicin by Modularizable Peptide Self-Assemblies for a Nanoscale Drug Carrier

Molecules, 2017
We prepared nanoscale, modularizable, self-assembled peptide nanoarchitectures with diameters less of than 20 nm by combining β-sheet-forming peptides tethering a cell-penetrating peptide or a nuclear localization signal sequence.
Kin-ya Tomizaki, Kohei Kishioka, Shunsuke Kataoka, Makoto Miyatani, Takuya Ikeda, Mami Komada, Takahito Imai, Kenji Usui   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source