Results 101 to 110 of about 929,541 (348)

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences [PDF]

Nucleic Acids Research, 2017
Fanconi anemia (FA) is a recessive genetic disorder characterized by congenital abnormalities, progressive bone-marrow failure, and cancer susceptibility. The FA pathway consists of at least 21 FANC genes (FANCA-FANCV), and the encoded protein products interact in a common cellular pathway to gain resistance against DNA interstrand crosslinks.
Niraj, J, Caron, M, Drapeau, K, Bérubé, S, Guitton-Sert, L, Coulombe, Y, Couturier, A, Masson, J   +7 more
openaire   +3 more sources

The sub-galactic and nuclear main sequences for local star-forming galaxies [PDF]

, 2016
We describe a sub-galactic main sequence (SGMS) relating star formation rate surface density ($\Sigma_{\textrm{SFR}}$) and stellar mass density ($\Sigma_{\star}$) for distinct regions within star forming galaxies, including their nuclei. We use a sample of 246 nearby star-forming galaxies from the "Star Formation Reference Survey" and demonstrate that ...
arxiv   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Halpha3: an Halpha imaging survey of HI selected galaxies from ALFALFA. III. Nurture shapes up the Hubble sequence in the Great Wall [PDF]

, 2013
We present the analysis of Halpha3, an Halpha imaging survey of galaxies selected from the HI ALFALFA Survey in the Coma Supercluster. By using the Halpha line as a tracer of the "instantaneous" star formation, complemented with optical colors from SDSS we explore the hypothesis that a morphological sequence of galaxies of progressively earlier type ...
arxiv   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Nuclear entry, oligomerization, and DNA binding of the Drosophila heat shock transcription factor are regulated by a unique nuclear localization sequence.

Genes & Development, 1997
In normally growing Drosophila cultured cells the Drosophila heat shock transcription factor (dHSF) is localized in the cytosol and translocates into the nucleus after heat shock.
Ebrahim Zandi, Thanh Nga T. Tran, Winston Chamberlain, C. S. Parker   +3 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B

Cells
The USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus.
Jacques S. Fritze, Felizitas F. Stiehler, Uwe Wolfrum   +2 more
doaj   +1 more source

High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

Molecular Systems Biology, 2020
Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking these phenotypes to genotype or RNA expression at scale remains challenging.
Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler   +12 more
doaj   +1 more source

The HIV-1 Tat Nuclear Localization Sequence Confers Novel Nuclear Import Properties [PDF]

Journal of Biological Chemistry, 1998
The different classes of conventional nuclear localization sequences (NLSs) resemble one another in that NLS-dependent nuclear protein import is energy-dependent and mediated by the cytosolic NLS-binding importin/karyopherin subunits and monomeric GTP-binding protein Ran/TC4.
Lyndall J. Briggs, Athina Efthymiadis, David A. Jans   +2 more
openaire   +3 more sources