Results 111 to 120 of about 929,541 (348)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Changing course: Glucose starvation drives nuclear accumulation of Hexokinase 2 in S. cerevisiae.

PLoS Genetics, 2023
Glucose is the preferred carbon source for most eukaryotes, and the first step in its metabolism is phosphorylation to glucose-6-phosphate. This reaction is catalyzed by hexokinases or glucokinases.
Mitchell A Lesko, Dakshayini G Chandrashekarappa, Eric M Jordahl, Katherine G Oppenheimer, Ray W Bowman, Chaowei Shang, Jacob D Durrant, Martin C Schmidt, Allyson F O'Donnell   +8 more
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

Engineering, 2015
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N ...
Wei Zhang, Xiaoli Yang, Jingjing Song, Xin Zheng, Jianbo Chen, Panpan Ma, Bangzhi Zhang, Rui Wang   +7 more
doaj   +1 more source

Nuclear import and dimerization of tomato ASR1, a water stress-inducible protein exclusive to plants. [PDF]

PLoS ONE, 2012
The ASR (for ABA/water stress/ripening) protein family, first described in tomato as nuclear and involved in adaptation to dry climates, is widespread in the plant kingdom, including crops of high agronomic relevance.
Martiniano M Ricardi, Francisco F Guaimas, Rodrigo M González, Hernán P Burrieza, María P López-Fernández, Elizabeth A Jares-Erijman, José M Estévez, Norberto D Iusem   +7 more
doaj   +1 more source

Bulges of disk galaxies at intermediate redshifts.II. Nuclear, disk and global colours in the Groth Strip [PDF]

, 2008
We analyse colours of the nuclear regions of intermediate redshift disk galaxies, with the aim of obtaining empirical information of relative ages of bulges and disks at 0.1 < z < 1.3. We work with an apparent-diameter limited parent sample of 248 galaxies from the HST Groth Strip Survey.
arxiv   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

The Protein Kinase CK2 Site (Ser111/112) Enhances Recognition of the Simian Virus 40 Large T-antigen Nuclear Localization Sequence by Importin*

Journal of Biological Chemistry, 1997
The mechanism by which phosphorylation regulates nuclear localization sequence (NLS)-dependent nuclear protein import is largely unclear. Whereas nuclear accumulation of SV40 large tumor antigen (T-ag) fusion proteins is completely dependent on the T-ag ...
S. Hübner, C. Xiao, D. Jans
semanticscholar   +1 more source

The directionality of the nuclear transport of the influenza A genome is driven by selective exposure of nuclear localization sequences on nucleoprotein [PDF]

Virology Journal, 2009
Background: Early in infection, the genome of the influenza A virus, consisting of eight complexes of RNA and proteins (termed viral ribonucleoproteins; vRNPs), enters the nucleus of infected cells for replication. Incoming vRNPs are imported into the nucleus of infected cells using at least two nuclear localization sequences on nucleoprotein (NP; NLS1
Wu, Winco W, Panté, Nelly
openaire   +5 more sources

More is different: 50 years of nuclear BCS [PDF]

, 2012
Many of the concepts which are at the basis of the development associated with a quantitative treatment of the variety of phenomena associated with the spontaneous breaking of gauge symmetry in nuclei have been instrumental in connection with novel studies of soft matter, namely of protein evolution and protein folding.
arxiv   +1 more source