Results 131 to 140 of about 709,714 (368)

Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

iScience, 2023
Summary: The eukaryotic BBSome is a transport complex within cilia and assembled by chaperonin-like BBS proteins. Recent work indicates nuclear functions for BBS proteins in mammals, but it is unclear how common these are in extant proteins or when they ...
Alexander Ewerling, Vanessa Maissl, Bill Wickstead, Helen Louise May-Simera   +3 more
doaj  

The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. [PDF]

PLoS ONE, 2015
Translocation to the nucleus of diacylglycerol kinase (DGK)- ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus.
Timothy D Rohrbach, Nishi Shah, William P Jackson, Erin V Feeney, Samantha Scanlon, Robert Gish, Ryan Khodadadi, Stephen O Hyde, Patricia H Hicks, Joshua C Anderson, John S Jarboe, Christopher D Willey   +11 more
doaj   +1 more source

Identification and functional characterization of protein domains in the transcription factor TWIST [PDF]

, 2006
Saethre-Chotzen syndrome is an autosomal dominant inherited disorder with premature fusion of cranial sutures. It is caused by nucleotide sequence changes within or in proximity of the TWIST1 gene. This gene encodes for a bHLH transcription factor, which
Kunz, Jürgen (Dr.), Singh, Shalini
core   +1 more source

The directionality of the nuclear transport of the influenza A genome is driven by selective exposure of nuclear localization sequences on nucleoprotein [PDF]

Virology Journal, 2009
Background: Early in infection, the genome of the influenza A virus, consisting of eight complexes of RNA and proteins (termed viral ribonucleoproteins; vRNPs), enters the nucleus of infected cells for replication. Incoming vRNPs are imported into the nucleus of infected cells using at least two nuclear localization sequences on nucleoprotein (NP; NLS1
Wu, Winco W, Panté, Nelly
openaire   +5 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Duck enteritis virus pUL47, as a late structural protein localized in the nucleus, mainly depends on residues 40 to 50 and 768 to 777 and inhibits IFN-β signalling by interacting with STAT1

Veterinary Research, 2020
Duck enteritis virus (DEV) is a member of the Alphaherpesvirinae subfamily. The characteristics of some DEV genes have been reported. However, information regarding the DEV UL47 gene is limited.
Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Renyong Jia, Ying Wu, Juan Huang, Shun Chen, Xin-Xin Zhao, Mafeng Liu, Dekang Zhu, Shaqiu Zhang, Xuming Ou, Sai Mao, Qun Gao, Di Sun, XinJian Wen, Bin Tian, Yunya Liu, Yanling Yu, Ling Zhang, Leichang Pan, Xiaoyue Chen   +22 more
doaj   +1 more source

Changing course: Glucose starvation drives nuclear accumulation of Hexokinase 2 in S. cerevisiae.

PLoS Genetics, 2023
Glucose is the preferred carbon source for most eukaryotes, and the first step in its metabolism is phosphorylation to glucose-6-phosphate. This reaction is catalyzed by hexokinases or glucokinases.
Mitchell A Lesko, Dakshayini G Chandrashekarappa, Eric M Jordahl, Katherine G Oppenheimer, Ray W Bowman, Chaowei Shang, Jacob D Durrant, Martin C Schmidt, Allyson F O'Donnell   +8 more
doaj   +1 more source

Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]

, 2010
At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick, Lasanajak, Yi, Proost, Paul, Rouge, Pierre, Schouppe, Dieter, Smith, David F, Van Damme, Els   +6 more
core   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Characterization of the Nucleocytoplasmic Transport Mechanisms of Epstein-Barr Virus BFLF2

Cellular Physiology and Biochemistry, 2018
Background/Aims: Epstein-Barr virus (EBV) BFLF2, the homologue of herpes simplex virus 1 (HSV-1) UL31, is crucial for the efficient viral DNA packaging and primary egress across the nuclear membrane.
Meili Li, Tao Chen, Xingmei Zou, Zuo Xu, Yuanfang Wang, Ping Wang, Xiaowen Ou, Yiwen Li, Daixiong Chen, Tao Peng, Yao Wang, Mingsheng Cai   +11 more
doaj   +1 more source