Results 291 to 300 of about 292,166 (318)
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Biochemical and Biophysical Research Communications, 2005
Nucleomorphin is a novel nuclear calmodulin (CaM)-binding protein (CaMBP) containing an extensive DEED (glu/asp repeat) domain that regulates nuclear number. GFP-constructs of the 38 kDa NumA1 isoform localize as intranuclear patches adjacent to the inner nuclear membrane.
Michael A, Myre, Danton H, O'Day
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Nucleomorphin is a novel nuclear calmodulin (CaM)-binding protein (CaMBP) containing an extensive DEED (glu/asp repeat) domain that regulates nuclear number. GFP-constructs of the 38 kDa NumA1 isoform localize as intranuclear patches adjacent to the inner nuclear membrane.
Michael A, Myre, Danton H, O'Day
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Multiple nuclear localization sequences in SRSF4 protein
Genes to Cells, 2020AbstractSRSF4 is one of the members of serine‐/arginine (SR)‐rich protein family involved in both constitutive and alternative splicing. SRSF4 is localized in the nucleus with speckled pattern, but its nuclear localization signal was not determined. Here, we have identified nuclear localization signals (NLSs) of SRSF4 by using a pyruvate kinase fusion ...
So Masaki +3 more
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Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles
ACS Nano, 2021Directing nanoparticles to the nucleus by attachment of nuclear localization sequences (NLS) is an aim in many applications. Gold nanoparticles modified with two different NLS were studied while crossing barriers of intact cells, including uptake, endosomal escape, and nuclear translocation.
Daniela Drescher +7 more
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Localization of AT-rich sequences at the nuclear matrix
Cell Biology International Reports, 1986After culture with 3H-thymidine murine erythroleukemia cells with more sites of DNA attached to the nuclear matrix have more labeled thymidine in their matrix-bound DNA than in their total DNA than do cells with fewer attachment sites. This indicates that the average attachment site sequence is enriched in A + T base pairs.
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Centromere sequences localize to the nuclear halo of human spermatozoa
International Journal of Andrology, 1998Chromatin is organized into a series of discrete nuclear matrix‐associated and non‐nuclear matrix‐associated domains. The non‐matrix‐associated domains consist of loops of DNA that are attached to the proteinaceous nuclear matrix by matrix‐associated regions (MARs). Although this organization is well characterized in somatic cells, comparatively little
Y, Yaron +6 more
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Synthesis and Binding Properties of Oligonucleotides Carrying Nuclear Localization Sequences
Bioconjugate Chemistry, 1999The synthesis of oligonucleotides carrying nuclear localization peptide sequences is described using two strategies: first, oligonucleotides carrying a thiol group at the 5' end were reacted with maleimido peptides; second, peptide and oligonucleotide were prepared stepwise on the same support, yielding oligonucleotide-3'-peptide conjugates.
B G, de La Torre +4 more
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The yeast nucleoporin Nsp1 binds nuclear localization sequences in vitro
Biochemistry and Cell Biology, 1996Facilitated transport of proteins into the nucleus requires nuclear localization sequences (NLSs) be present in the protein destined for the nucleus. The specific binding of NLSs by components of the nuclear transport apparatus is essential for these targeting reactions.
W, Barth, U, Stochaj
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Journal of Molecular Biology, 2007
The influenza A genome consists of eight single-stranded RNA molecules, each associated with an oligomeric core of the structural protein, nucleoprotein, to form a distinct viral ribonucleoprotein (vRNP) complex. vRNPs are the entities responsible for the transcription and replication of the influenza viral RNAs in the nuclei of host cells.
Winco W H, Wu +2 more
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The influenza A genome consists of eight single-stranded RNA molecules, each associated with an oligomeric core of the structural protein, nucleoprotein, to form a distinct viral ribonucleoprotein (vRNP) complex. vRNPs are the entities responsible for the transcription and replication of the influenza viral RNAs in the nuclei of host cells.
Winco W H, Wu +2 more
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The Immunoreactive Region in a Novel Autoantigen Contains a Nuclear Localization Sequence
Clinical Immunology and Immunopathology, 1994Antibodies in the serum of patients with autoimmune diseases have been used to identify human autoantigens. Because autoantibodies often recognize active sites within corresponding protein antigens, autoantibodies have facilitated the functional characterization of these polypeptides.
D B, Bloch +3 more
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Identification of a nuclear localization sequence in the polyomavirus capsid protein VP2
Virology, 1992A nuclear localization signal (NLS) has been identified in the C-terminal (Glu307-Glu-Asp-Gly-Pro-Gln-Lys-Lys-Lys-Arg-Arg-Leu318) amino acid sequence of the polyomavirus minor capsid protein VP2. The importance of this amino acid sequence for nuclear transport of newly synthesized VP2 was demonstrated by a genetic "subtractive" study using the ...
D, Chang +3 more
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